Clinical Implications of Transbronchial Biopsy for Surgically-resected Non-small Cell Lung Cancer

Yasukawa, Motoaki; Sawabata, Noriyoshi; Kawaguchi, Takeshi; Kawai, Norikazu; Taniguchi, Shigeki

doi:10.21873/invivo.11295

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…We screened 456 articles, and finally included 11 articles [ 8 , 19 – 28 ] according to the inclusion and exclusion criteria. The literature screening is shown in supplementary figure S1 .…”

Section: Resultsmentioning

confidence: 99%

“…Some studies have pointed out that pre-operative bronchoscopy diagnosis does not increase the risk of recurrence of stage IA nonsmall cell lung cancer (NSCLC) [ 7 ]. However, other studies have shown that pre-operative fibreoptic bronchoscopy with fluorescence imaging is a prognostic factor in NSCLC patients undergoing surgery [ 8 ]. Tumours diagnosed by bronchoscopy might have a worse prognosis [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…The differences between this study and previous studies [ 8 , 19 – 28 ] are that this study was an exhaustive real-world study to explore the impact of pre-operative biopsy, including ultrasound- or CT-guided lung biopsy, bronchial mucosa biopsy and transbronchial lung biopsy, on the overall recurrence, local recurrence, distant metastasis, combined recurrence, pleural recurrence, DFS and overall survival of patients with stage I lung adenocarcinoma after surgical resection.…”

Section: Discussionmentioning

confidence: 99%

“…The conclusion is still controversial. In addition, whether bronchoscopic biopsy increases a patient's risk of recurrence and affects prognosis has not been determined [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of pre-operative biopsy on recurrence and survival in stage I lung adenocarcinoma patients in China

Zhang

et al. 2023

ERJ Open Res

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BackgroundWhether preoperative biopsy affects postoperative recurrence and metastasis of lung cancer patients is still controversial.MethodsIn order to clarify the disputes mentioned above, we collected relevant literatures to conduct a meta-analysis. Furthermore, to validate the results of the meta-analysis, we retrospectively analysed 575 patients with stage I lung adenocarcinoma who underwent surgical resection in our center from 2010 to 2018 using propensity score matching and competing risk models.Results5509 lung cancer patients from 11 articles were included in the meta-analysis. Summary analysis showed the total recurrence rate of biopsy group was higher than that of non-biopsy group (Risk radio (RR)=1.690 (1.220, 2.330), p=0.001). After propensity score matching, we found that there was no significant correlation between biopsy and total recurrence (RR=1.070 (0.540, 2.120), p=0.850). In our cohort, of 575 stage I lung adenocarcinomas, 113 (19.7%) patients underwent preoperative biopsy. During a median follow-up of 71 (57, 93) months, multivariable analyses showed preoperative biopsy in the overall observation cohort [sub-distribution hazard ratio (SHR)=1.522; 95% confidence interval (CI): 0.997–2.320; p=0.051] and in the propensity score-matched cohort (SHR=1.134; 95% CI: 0.709–1.810; p=0.600) was not significantly correlated with the risk of recurrence and metastasis. What's more, preoperative biopsy didn't affect disease-free survival (SHR=0.853, 95%CI: 0.572–1.273; p=0.438) and overall survival (SHR=0.647, 95%CI: 0.352–1.189; p=0.161).ConclusionPreoperative biopsy might not increase the risk of recurrence and metastasis, suggesting these procedures might be safe for patients with stage I lung adenocarcinoma whose diagnosis is difficult to determine before surgery.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The conclusion is still controversial. In addition, whether bronchoscopic biopsy increases a patient's risk of recurrence and affects prognosis has not been determined [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of pre-operative biopsy on recurrence and survival in stage I lung adenocarcinoma patients in China

Zhang

et al. 2023

ERJ Open Res

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CT texture analysis for prediction of EGFR mutational status and ALK rearrangement in patients with non-small cell lung cancer

et al. 2021

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Interpretable Deep Model For Predicting Gene-Addicted Non-Small-Cell Lung Cancer In Ct Scans

Pino

Palazzo

Trenta

et al. 2021

2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)

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Genetic profiling and characterization of lung cancers have recently emerged as a new technique for targeted therapeutic treatment based on immunotherapy or molecular drugs. However, the most effective way to discover specific gene mutations through tissue biopsy has several limitations, from invasiveness to being a risky procedure. Recently, quantitative assessment of visual features from CT data has been demonstrated to be a valid alternative to biopsy for the diagnosis of gene-addicted tumors. In this paper, we present a deep model for automated lesion segmentation and classification as gene-addicted or not. The segmentation approach extends the 2D Tiramisu architecture for 3D segmentation through dense blocks and squeeze-and-excitation layers, while a multi-scale 3D CNN is used for lesion classification. We also train our model with adversarial samples, and show that this approach acts as a gradient regularizer and enhances model interpretability. We also built a dataset, the first of its nature, consisting of 73 CT scans annotated with the presence of a specific genomics profile. We test our approach on this dataset achieving a segmentation accuracy of 93.11% (Dice score) and a classification accuracy in identifying oncogene-addicted lung tumors of 82.00%.

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Clinical Implications of Transbronchial Biopsy for Surgically-resected Non-small Cell Lung Cancer

Abstract: Abstract. Background

Cited by 5 publications

References 13 publications

Effects of pre-operative biopsy on recurrence and survival in stage I lung adenocarcinoma patients in China

Effects of pre-operative biopsy on recurrence and survival in stage I lung adenocarcinoma patients in China

CT texture analysis for prediction of EGFR mutational status and ALK rearrangement in patients with non-small cell lung cancer

Interpretable Deep Model For Predicting Gene-Addicted Non-Small-Cell Lung Cancer In Ct Scans

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