Clinical implications of underactive bladder

Ko, Kwang Jin; Lee, Chung Un; Lee, Kyu‐Sung

doi:10.4111/icu.2017.58.s2.s75

Cited by 8 publications

(6 citation statements)

References 52 publications

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“…It has been hypothesized that some DO may be the compensatory effect of increased outlet resistance, as it frequently coexists with benign prostatic obstruction and pelvic organ prolapse. [20][21][22] F I G U R E 2 This hypothetical model shows that, if the degree of bladder sensation (afferent sensory function) increases abnormally, storage symptoms are more severe. On the other hand, the lower the degree of bladder contraction (efferent contractile function), the more severe the emptying symptoms are, with or without the corresponding urodynamic diagnosis.…”

Section: Pathophysiologymentioning

confidence: 99%

Is coexistent overactive–underactive bladder (with or without detrusor overactivity and underactivity) a real clinical syndrome? ICI‐RS 2019

Mancini

Tarcan

Serati

et al. 2020

Neurourology and Urodynamics

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Aims Lower urinary tract symptoms (LUTS) can be classified into symptom syndromes based on which symptoms are predominant. Overactive bladder (OAB) syndrome, a storage dysfunction, and underactive bladder (UAB) syndrome, a voiding dysfunction, are common syndromes, which urodynamic tests may show to be caused by detrusor overactivity (DO) and detrusor underactivity (DU), but can also be associated with other urethro‐vesical dysfunctions. Sometimes OAB and UAB can coexist in the same patient and, if so, need a specific approach beyond treatment of the single and apparently opposing syndromes. Methods During its 2019 meeting in Bristol, the International Consultation on Incontinence Research Society held a literature review and expert consensus discussion focused on the emerging awareness of the coexisting overactive–underactive bladder (COUB). Results The consensus considered whether COUB is the combination of OAB and UAB syndromes, or a real unique clinical syndrome in the same patient, possibly with a common etiology. Definitions, pathophysiology, diagnosis, and treatment were discussed, and high‐priority research questions were identified. Conclusions COUB (with or without urodynamic evidence of DO and DU) may be considered a real clinical syndrome, because it differs from single OAB and UAB, and may not be the combination of both syndromes. Urodynamic tests may be necessary in unclear cases or in cases not responding to initial treatment of the most troublesome symptoms. It is pivotal to define the evolution of the syndrome and the characteristic population, and to recognize predictive or phenotyping factors to develop a specific approach and adequate outcome measures.

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Section: Pathophysiologymentioning

confidence: 99%

Is coexistent overactive–underactive bladder (with or without detrusor overactivity and underactivity) a real clinical syndrome? ICI‐RS 2019

Mancini

Tarcan

Serati

et al. 2020

Neurourology and Urodynamics

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show abstract

“…UAB refers to the complicated condition associated with difficulty in expelling urine from the bladder, which is characterized by major symptoms such as prolonged urination time, hesitancy, reduced sensation on filling, and a slow stream [24]. According to Ko et al [25], UAB involves detrusor underactivity (DU) overlapping with bladder outlet obstruction (BOO), overactive bladder, and/or stress urinary incontinence. According to a report in South Korea, DU was observed in 40.2% of men with LUTS [26].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Clinical Outcomes of Prostatic Urethral Lift for Benign Prostatic Hyperplasia: An Asian Population Study

Kim

Lee

Kim

2020

World J Mens Health

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An aged society is a country that has more than 14% of its population aged 65 or older. South Korea became an aging society in 2000 and has remained an aged society through the years since 2000. The trend of an increasing population of elderly individuals is occurring not only in Korea but also in other developed countries and nations worldwide. As the population ages, it is associated with many health problems, such as urinary

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“…UAB is a complex urologic condition with severe complications, such as bladder outlet obstruction and stress urinary incontinence (SUI). Interstitial Cajal-like cells (ICC-LCs), pacemaker cells in the urinary system, have shown a downward trend in UAB ( Feng et al, 2017 ) and have thus emerged as an ideal therapy to satisfactorily adjust spontaneous vesical contractions ( Liu et al, 2017a ; Ko et al, 2017 ). By transfecting lentiviral vectors with exogenous gene hyperpolarization-activated cyclic nucleotide-gated (HCN4) modification, Sun et al inefficiently induced the directional differentiation of USCs into ICC-LCs, resulting in a morphological alteration from “rice grain”-like cells to spindle-shaped cells with multiple branches, higher expression of the ICC surface marker c-Kit, and a visible automatic depolarization current.…”

Section: Applications Of Uscsmentioning

confidence: 99%

A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells

et al. 2022

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Stem cells possess regenerative powers and multidirectional differentiation potential and play an important role in disease treatment and basic medical research. Urine-derived stem cells (USCs) represent a newly discovered type of stem cell with biological characteristics similar to those of mesenchymal stromal cells (MSCs), including their doubling time and immunophenotype. USCs are noninvasive and can be readily obtained from voided urine and steadily cultured. Based on advances in this field, USCs and their secretions have increasingly emerged as ideal sources. USCs may play regulatory roles in the cellular immune system, oxidative stress, revascularization, apoptosis and autophagy. This review summarizes the applications of USCs in tissue regeneration and various disease treatments. Furthermore, by analysing their limitations, we anticipate the development of more feasible therapeutic strategies to promote USC-based individualized treatment.

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Clinical implications of underactive bladder

Cited by 8 publications

References 52 publications

Is coexistent overactive–underactive bladder (with or without detrusor overactivity and underactivity) a real clinical syndrome? ICI‐RS 2019

Is coexistent overactive–underactive bladder (with or without detrusor overactivity and underactivity) a real clinical syndrome? ICI‐RS 2019

Evaluation of Clinical Outcomes of Prostatic Urethral Lift for Benign Prostatic Hyperplasia: An Asian Population Study

A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells

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