Clinical Importance of Purulence in Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infections

Crawford, Susan E.; David, Michael Z.; Glikman, Daniel; King, Kimberly J; Boyle-Vavra, Susan; Daum, Robert S.

doi:10.3122/jabfm.2009.06.090025

Cited by 21 publications

(17 citation statements)

References 35 publications

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“…Our results are supported by other studies that failed to find reliable clinical or epidemiological factors that could reliably distinguish MRSA and methicillin-sensitive Staphylococcus aureus (MSSA) infections (8,9). Although we did not specifically evaluate historical …”

Section: Discussionsupporting

confidence: 68%

Clinical and Epidemiologic Characteristics as Predictors of Treatment Failures in Uncomplicated Skin Abscesses Within Seven Days After Incision and Drainage

Olderog

Schmitz

Bruner

et al. 2012

The Journal of Emergency Medicine

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Section: Discussionsupporting

confidence: 68%

Clinical and Epidemiologic Characteristics as Predictors of Treatment Failures in Uncomplicated Skin Abscesses Within Seven Days After Incision and Drainage

Olderog

Schmitz

Bruner

et al. 2012

The Journal of Emergency Medicine

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“…S. aureus clinical isolates carrying PVL genes are often associated with SSTIs requiring incision and drainage[22–24], and the production of PVL correlated with SSTI severity in the aforementioned S. aureus animal model[11]. In our study, the expression level of lukS mRNA among SSTI isolates was significantly higher than that among BSI isolates, potentially indicating that quantitative PVL gene expression plays a more important role in S. aureus SSTIs than for other clinical presentations.…”

Section: Discussionmentioning

confidence: 54%

Expression of Panton-Valentine Leukocidin mRNA among Staphylococcus aureus Isolates Associates with Specific Clinical Presentations

Liu

et al. 2013

PLoS ONE

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Panton-Valentine leukocidin (PVL; gene designation lukF/S-PV) is likely an important virulence factor for Staphylococcus aureus (S. aureus), as qualitative expression of the protein correlates with severity for specific clinical presentations, including skin and soft tissue infections (SSTIs). Development of genetic approaches for risk-assessment of patients with S. aureus infections may prove clinically useful, and whether lukF/S-PV gene expression correlates with specific clinical presentations for S. aureus has been largely unexplored. In the present study, we quantified lukS-PV mRNA among 96 S. aureus isolates to determine whether expression levels correlated with specific clinical presentations in adults and children. Expression level of lukS-PV mRNA among isolates from skin and soft tissue infections (SSTIs) was significantly greater than among isolates from blood stream infection (BSIs), and expression level of lukS-PV mRNA among BSI isolates from children was significantly greater than for BSI isolates among adults. Moreover, expression level of lukS-PV mRNA among community-acquired (CA) isolates was significantly greater than for hospital-acquired (HA) isolates. These data justify additional studies to determine the potential clinical utility for lukS-PV mRNA quantification as a predictive tool for severity of S. aureus infection.

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“…Therefore, the presence of purulence at the time of resection indicates larger tissue involvement and mandates more aggressive débridement. In addition, the presence of purulence predicts the antibiotic sensitivity of methicillinresistant S. aureus [9]. This finding may be helpful in the selection of appropriate empiric antibiotic therapy before the culture result and in culture-negative PJI.…”

Section: Discussionmentioning

confidence: 98%

Two-stage Exchange Arthroplasty for Infected Total Knee Arthroplasty: Predictors of Failure

Mortazavi

Vegari

et al. 2011

Clinical Orthopaedics &Amp; Related Research

319

164

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Clinical Importance of Purulence in Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infections

Cited by 21 publications

References 35 publications

Clinical and Epidemiologic Characteristics as Predictors of Treatment Failures in Uncomplicated Skin Abscesses Within Seven Days After Incision and Drainage

Clinical and Epidemiologic Characteristics as Predictors of Treatment Failures in Uncomplicated Skin Abscesses Within Seven Days After Incision and Drainage

Expression of Panton-Valentine Leukocidin mRNA among Staphylococcus aureus Isolates Associates with Specific Clinical Presentations

Two-stage Exchange Arthroplasty for Infected Total Knee Arthroplasty: Predictors of Failure

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