2022
DOI: 10.1186/s12967-022-03752-6
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Clinical improvement of sepsis by extracorporeal centrifugal leukocyte apheresis in a porcine model

Abstract: Background Extracorporeal blood purification therapies targeting removal of the downstream products of the inflammatory cascade in sepsis have failed to improve mortality. As an upstream process of the inflammatory cascade, activated white blood cells should be a potential therapeutic target for sepsis, and the effect of removing such cells by extracorporeal centrifugal leukocytapheresis (LCAP) is worth considering. Methods Fourteen peritonitis-ind… Show more

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