2017
DOI: 10.1080/08039488.2017.1420819
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Clinical improvement, relapse and treatment adherence with paliperidone palmitate 1-month formulation: 1-year treatment in a naturalistic outpatient setting

Abstract: This naturalistic study indicates that long-term PP1M treatment was safe and effective in preventing hospitalizations and urgent consultations as well as in improving clinical course.

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Cited by 11 publications
(9 citation statements)
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“…With regard to the primary objective of this study, PP, Hal-D, and Apr prolonged release proved to be equally effective in the prevention of relapses both at 6 and 12 months, resulting in a significant decrease in urgent consultations, psychiatric hospitalizations, and days of hospitalization. Our study confirms results obtained from previous research conducted with mirror analysis23,26,7375 or cohort-study design25,30 that demonstrated greater efficacy of LAI-APDs compared to oral APD therapies in the prevention of relapses. These results were not confirmed by the double-blind RCTs,6 probably because RCTs are not an optimal study methodology for effectiveness studies in clinical practice 29.…”
Section: Discussionsupporting
confidence: 90%
“…With regard to the primary objective of this study, PP, Hal-D, and Apr prolonged release proved to be equally effective in the prevention of relapses both at 6 and 12 months, resulting in a significant decrease in urgent consultations, psychiatric hospitalizations, and days of hospitalization. Our study confirms results obtained from previous research conducted with mirror analysis23,26,7375 or cohort-study design25,30 that demonstrated greater efficacy of LAI-APDs compared to oral APD therapies in the prevention of relapses. These results were not confirmed by the double-blind RCTs,6 probably because RCTs are not an optimal study methodology for effectiveness studies in clinical practice 29.…”
Section: Discussionsupporting
confidence: 90%
“…17 A recent systematic review has estimated at 3% the one-year recurrence rate for patients who continued antipsychotics whereas the risk of recurrence is increased to over 90% among patients who had discontinued antipsychotic therapy within 2 years. 18 There is a general consensus on the fact that lack of adherence represents the major criticality in treatments, especially long-term ones, in the most severely ill patients 19 with further negative repercussions on both the patient's quality of life and Mental Health Services. 20 One of the most immediate consequences of lack of adherence is a high rate of relapse, which can favour the so-called "revolving door" phenomenon.…”
Section: Introductionmentioning
confidence: 99%
“…54 The main causes of drug discontinuation before the planned study end were adverse events 45,46,61,62,65 and ineffectiveness. 47,51,59,62,65,66 The two available long-term studies on PPM3 showed a rate of premature discontinuation similar to that shown by the active comparator (PP1M). 68,69 However, only one 68 reported the reasons of premature withdrawal (the most frequent being the occurrence of adverse events).…”
Section: Discussionmentioning
confidence: 87%
“…In the small study by Di Lorenzo et al ., the main causes of dropout were lack of therapeutic adherence and inefficacy.…”
Section: Resultsmentioning
confidence: 99%
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