Clinical Influence of the Lymph Node Ratio on Lymph Node Metastasis-positive Gastric Cancer Patients Who Receive Curative Treatment

Abstract

Background/Aim: The present study investigated the clinical impact of the lymph node ratio (LNR) on overall survival (OS) and recurrence-free survival (RFS) in cancer patients with lymph node metastasis who received curative treatment. Patients and Methods: Eighty-six patients who received curative surgery for gastric cancer between 2000 and 2015, and in whom lymph node metastasis was pathologically confirmed, were included in this study. The LNR was defined as the ratio of the number of metastatic lymph nodes to the total number of harvested lymph nodes. Results: A lymph node ratio of 0.23 was considered the optimal cutoff point for classification according to OS. Statistically significant differences were observed in the 3and 5-year OS rates and 3-and 5-year RFS rates. The 3year and 5-year OS rates in the LNR <0.23 group were 57.6% and 57.6%, respectively, whereas those in the LNR ≥0.23 group were 33.0% and 0% (p<0.001). The 3-year and 5-year RFS rates in the LNR <0.23 group were 45.9% and 43.6%, respectively, whereas those in the LNR >0.23 group were 25.2% and 0% (p=0.002). Regarding the site of first relapse, the incidence rates of peritoneal and lymph node metastasis in the LNR >0. 23 group were significantly different in comparison to the LNR <0.23 group. Conclusion: A high LNR was associated with significantly worse OS and RFS in patients who received curative treatment for gastric cancer. The lymph node metastasis status should be utilized in the development of treatment strategies for gastric cancer.

Low Expression of miR-491-3p Is Correlated with Lymph Node Metastasis in Gastric Cancer

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Comparison of the predictive performance of three lymph node staging systems for late-onset gastric cancer patients after surgery

“…In our study, we showed that the LNR was a more appropriate LN system for assessing patient prognosis. Despite similar findings reported in prior studies (53)(54)(55)(56)(57)(58)(59), some of which also utilized data from the SEER database (54,58), our study possesses some distinct characteristics that differentiate it from earlier research. We collected SEER data from 2010 to 2020.…”

Safety and Efficacy of Carbon Nanoparticle-Labeled Lymph Node Dissection in Radical Resection of Gastric Cancer: A Systematic Review and Meta-Analysis

“… 1 Currently, radical GC surgery is the only means to cure locally progressive GC; however, lymph node (LN) metastasis in most GC patients greatly affects survival and prognosis. 2 – 4 LN metastasis is an independent risk factor for tumor recurrence after radical GC surgery, and standardized and thorough LN dissection is directly related to the clinical prognosis of GC patients. Therefore, strengthening intraoperative LN tracing and dissection is the key direction of GC treatment.…”