Clinical interval and diagnostic characteristics in a cohort of bladder cancer patients in Spain: a multicenter observational study

Bonfill, Xavier; Martinez-Zapata, María José; Vernooij, Robin W.M.; Sánchez, María José; Suárez-Varela, María Morales; Cruz, Javier de la; Emparanza, José Ignacio; Ferrer, Montse; Pijoán, José Ignacio; Palou, Joan; Schmidt, Stefanie; Madrid, Eva; Abraira, Víctor; Zamora, Javier

doi:10.1186/s13104-017-3024-8

Cited by 3 publications

(6 citation statements)

References 25 publications

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“…The mean age of BC diagnosis was similar to the one reported in the other series [ 7 , 37 , 38 ], without differences between both genders. As in the previous study [ 7 ], the incidence of this cancer in Vallès Occidental is ten times higher in men than in women, while in the World Population, it is only four times higher.…”

Section: Discussionsupporting

confidence: 86%

Environmental Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North‐Eastern Spain

Caballero

Pérez-Márquez

Gili

et al. 2022

Journal of Environmental and Public Health

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Background. Bladder cancer (BC) is the most common of those affecting the urinary tract, and a significant proportion of the cases are attributable to tobacco use as well as occupational and environmental factors. Objective. The aim of this study is to estimate the current incidence of BC in an industrialized area in northeastern Spain and to analyze its time trends over three decades from an ecological perspective. Methods. Patients diagnosed with histologically confirmed primary BC, during 2018-2019, in an area in northeastern Spain (430,883 inhabitants) were included. Crude and age-standardized incidence rates were estimated per 100,000 person-years based on the number of individuals getting their first diagnosis. An exploratory time trend analysis was carried out to describe the evolution in tobacco use and occupational or environmental risk factors and the incidence of BC in the same area from the 1990s. Results. 295 patients were included (age 72.5 ± 10.3 years; 89.8% men). The crude rate was 62.6 (95% CI: 51.9–73.2) for men and 6.8 (95% CI: 3.4–10.3) for women. The annual rate adjusted to the European Standard Population was 85.3 (95% CI:75.0–95.5) for men and 7.0 (95% CI:4.5–9.5) for women. From 1994 to 2018, the prevalence of smokers decreased in men (42.3% to 30.9%) as well as in the active population working in the industry (44.36% to 22.59%). Nevertheless, the car fleet, especially diesel, has increased considerably. The annual mean concentrations of air (PM10, PM2.5, O3, and NO2) and water (nitrates, arsenic, trihalomethanes) pollutants were within the regulatory limit values, but not the maximum levels. Conclusions. The incidence of BC is one of the highest in men but not in women, despite the decrease in tobacco use and industrial activity (perhaps related to high latency after carcinogen exposure cessation) and despite the control of environmental pollution (the maximum regulatory limit probably needs to be lowered). Finally, a similar exposure to the carcinogen would result in a gender-specific differential incidence.

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Section: Discussionsupporting

confidence: 86%

Environmental Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North‐Eastern Spain

Caballero

Pérez-Márquez

Gili

et al. 2022

Journal of Environmental and Public Health

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“…En el realizado por el grupo ICBP en 2018, las medianas para el CCR oscilaron entre 27 y 76 días 19 y para el pulmón entre 25 y 45 18 . En el estudio de Bonfill et al, el tiempo invertido en el diagnóstico desde la consulta de urología tiene una mediana de 89 días en próstata 25 y 104 en vejiga 30 .…”

Section: Discussionunclassified

“…En cuanto al IT se describen tiempos prolongados principalmente en CCR, próstata y vejiga. Otros estudios han mostrado IT menores 9 , 28 , 30 .…”

Section: Discussionunclassified

Demora en el diagnóstico y tratamiento de 5 tipos de cáncer en 2 centros de salud urbanos

León¹,

Fuentes²,

Bendala³

et al. 2022

Atención Primaria

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“…Methods were previously published. [ 2 ] The research ethics committees from the 7 tertiary participating hospitals approved the protocol. Consecutive bladder cancer patients were identified from the urology and oncology departments.…”

Section: Methodsmentioning

confidence: 99%

“…Baseline characteristics, diagnostic and therapeutic intervals in this cohort were previously published. [ 2 ] Quality of life (QoL) of this cohort was also reported. [ 6 ] In this article, we presented patient-important outcomes and treatments received during the first 12-months follow-up after diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Follow-up care of 12 months of patients with bladder cancer in Spain: A multicenter prospective cohort study

et al. 2022

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The therapeutic approach of bladder cancer strongly determines its prognosis. We describe the treatments and outcomes for a Spanish cohort of patients with bladder cancer for the first 12 months after diagnosis and identify the factors that influenced the decision to undergo the treatment received. We conducted a multicenter, prospective, cohort study including primary bladder cancer patients during the first 12 months after diagnosis. The clinical outcomes were performance status (ECOG), adverse events and any cause of mortality. We stratified the analysis by factors that might influence the treatments received. We conducted univariate and multivariable logistic regression models to assess which patient and tumor characteristics were associated with receiving adjuvant treatment in the subgroup of noninvasive bladder cancer patients. In total, 314 patients were included (85% men; 53.8% >70 years) in 7 tertiary Spanish hospitals; 82.2% had a noninvasive urothelial bladder cancer (NMIBC). Patients received mostly surgery plus adjuvant therapy (67.7%). BCG (32.8% patients) was the most frequently administered adjuvant therapy, followed by intravesical chemotherapy (17.8% patients) and radiotherapy (10.8%). The variability of administered treatments among hospitals was low. Patients with NMIBC were more likely to receive adjuvant therapy if they had a higher educational level, some comorbidities and a high-grade tumor. The number of fully active patients (ECOG 0) significantly decreased during the first year of follow-up from 58% to 36 % (OR: 2.41, 95%CI 1.82–3.20); at 12-month follow-up 10.8% patients had died from any cause. In conclusion, most of the patients had a NMIBC. Surgery alone or plus adjuvant therapy were the commonest curative options of bladder cancer. BCG therapy was the adjuvant therapy most frequently administered. Higher educational level, presence of comorbidities and a high-grade tumor were associated with adjuvant therapy. Patient performance status was worsening over time. Almost 1 of 10 patients died during the first year of follow-up.

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Clinical interval and diagnostic characteristics in a cohort of bladder cancer patients in Spain: a multicenter observational study

Cited by 3 publications

References 25 publications

Environmental Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North‐Eastern Spain

Environmental Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North‐Eastern Spain

Demora en el diagnóstico y tratamiento de 5 tipos de cáncer en 2 centros de salud urbanos

Follow-up care of 12 months of patients with bladder cancer in Spain: A multicenter prospective cohort study

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