Clinical investigation of gastric function

Effect of Age on Gastric Acid, Pepsin, Pepsinogen Group A and Gastrin Secretion in Peptic Ulcer Patients

“…Our study found acid output unchanged in the various age groups, even when acid secre tion was corrected in relation to FFB, which is known to change significantly with age, espe cially in women [19]. This study confirms findings in young-adult populations [1] that elderly DU patients produce more acid than those with GU and males reveal a higher gas tric acid output than females with both pathologies. These results agree with the find ings of Tatsuta and Okuda [20], who used Congo red staining to study the gastric muco sa of 565 subjects and demonstrated in DU patients a significantly more developed acidsecreting area even in the over-60-year-olds.…”

“…With regard to gastric acid output there is clinical and epidemiological evidence to dem onstrate that there is a different secretory pat-tern between duodenal ulcer patients (DU), who are mainly acid hypersecretors, and gas tric ulcer patients (GU), who generally have normal or lower than normal gastric acid out put [1]. The literature is less clear on the mat ter of peptic secretion, but some reports con firm a difference in behavior between GU, which features a normal or lower pepsin and pepsinogen output, and DU, where an in creased secretion of the enzyme is prevalent [2][3][4].…”