Clinical Investigation on Pulmonary Metastasis of Head and Neck Carcinomas

Osaki, Tokio; Yoneda, Kazunori; Yamamoto, Tetsuya; Kimura, T.; Matuoka, Hisakazu; Sakai, H.; Ryoke, Kazuo

doi:10.1159/000012161

Cited by 16 publications

(9 citation statements)

References 47 publications

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“…Distant metastases from head and neck squamous cell carcinoma involve the lungs most frequently. 16 Screening for pulmonary metastases with computed tomography (CT) scanning, targeted at the high risk population, de ned by tumour stage and histological cell type, has been recommended. 15 Extracapsular spread and positive cervical lymph nodes have also been recognized to be associated with a high (40 per cent) risk of distant metastases.…”

Section: -12mentioning

confidence: 99%

The cause of death in patients with head and neck squamous cell carcinoma

2002

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Section: -12mentioning

confidence: 99%

The cause of death in patients with head and neck squamous cell carcinoma

2002

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“…A previous study showed that the rate of distant metastasis from the tongue was 4.1%, and was lower than that from upper gingiva carcinomas (6.6%). [ 113 ] The lip cancer comprises 30% of the oral cancer and 2.06% of all cancer cases. [ 114 115 ] The lip carcinoma shows regional lymph node metastasis in 3–29% of cases.…”

Section: Discussionmentioning

confidence: 99%

Distant metastasis from oral cancer: A review and molecular biologic aspects

Irani

2016

J Int Soc Prevent Communit Dent

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Oral squamous cell carcinoma (OSCC) has been estimated to be the sixth most common cancer worldwide. The distant metastasis plays a critical role in the management and prognosis in oral cancer patients. Regarding the distant metastasis from the oral cancer, the hypopharynx is the most common primary site, followed by the base of tongue and anterior tongue. The present review article analyzes the characteristics of the distant metastases from the oral cavity from 1937 to 2015.

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“…However, its importance is increasing as loco-regional control improves. Blood borne spread most often involves lung 75,76 . The best predictor of the likelihood of spread is involvement of the neck at multiple levels.…”

Section: Tumor Spreadmentioning

confidence: 99%

Oral Cancer - An Overview

Radhakrishnan¹,

Shrestha²,

Bajracharya³

2012

Oral Cancer

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Neoplasms of diverse cellular origin arise in the oral cavity and among these oral squamous cell carcinoma (OSCC) arising from the mucosa of the oral cavity constitutes to over 90% 1, 2. Oral cancer encompasses all the malignancies originating in the oral tissues, including cancers of the lip, tongue, gingiva, floor of the mouth, buccal mucosa, palate and the retromolar trigone. It is the 6 th most common cancer worldwide 3. Oral squamous cell carcinoma is described as an invasive epithelial neoplasm with varying degrees of squamous differentiation and a propensity to early and extensive lymph node metastases, occurring predominantly in alcohol and tobacco using adults generally in the 5 th and 6 th decades of life. Globally about 5, 00,000 new cases of oral and oropharyngeal cancers are diagnosed and three quarters of these are from the developing world 7, 8, 9. Approximately 3, 89,650 cases occurred in the year 2000 out of which 2, 66,672 were in the oral cavity (ICD-9 140-5) and 1, 22,978 for the cancer of oropharynx (ICD-9 146, 8-9). This represented about 5% of all cancers for men and 2% for women 10. Oral and oropharyngeal cancers remain one of the more common cancers in the South and South East Asian countries, as opposed to Western society, where it accounts for only about 1-4% of the of reported cancers incidence 4. For example, the incidence of oral cancer in India is high, constituting about 12% of all cancer in men and 8% in women 5 ; mortality rate is equally high in this population, ranking number one in men and number three in women 6. Oral and oropharyngeal cancers therefore qualify as major public health problem, not only in India, but also globally. Worldwide, oral cancer incidence rates appear to have been stabilizing over the last decade 12 , but the greater frequency of oral cancer in certain regions and among specific populations is a cause for concern since their overall 5-year survival rate is 53% and it has not changed in the last two decades 13. With this heightened awareness, research to further investigate the detection, diagnosis and prevention or oral cancer has recently been included as one of the targeted priorities supported by the National Institute of Dental and Craniofacial Research (NIDR) in the United States 14. The overall 5-year survival rate for patients without clinically evident cervical lymph node metastases is 85%. However, patients with microscopic lymph node metastases have a survival rate of 54%. It has been estimated that 20-50% of patients without clinically evident cervical lymph node metastases do in fact have microscopic metastases and therefore poorer www.intechopen.com Oral Cancer 48 prognosis 87. Among the Indian population, the overall 5-year observed and relative survival rates were 30.5% and 39.7%, respectively. Survival steadily declined with advancing age and advanced clinical stages. 5-year observed survival was 59.1% for localized cancer, 15.7% for cancers with regional extension and 1.6% for those with distant metastasis. Those with tongue, buccal mu...

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Clinical Investigation on Pulmonary Metastasis of Head and Neck Carcinomas

Cited by 16 publications

References 47 publications

The cause of death in patients with head and neck squamous cell carcinoma

The cause of death in patients with head and neck squamous cell carcinoma

Distant metastasis from oral cancer: A review and molecular biologic aspects

Oral Cancer - An Overview

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