Clinical issues in cannabis use

Bonomo, Yvonne; Souza, José Diogo S.; Jackson, Aidan; Crippa, José Alexandre de Souza; Solowij, Nadia

doi:10.1111/bcp.13703

Cited by 20 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cannabis products are widely employed worldwide, and their use has been illegalized in several countries ( Bonomo et al, 2018 ). After legalizing medicinal and recreational cannabis in some countries, its use highly increased ( Wen et al, 2015 ; Martins et al, 2016 ; Hasin et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations

et al. 2022

Self Cite

View full text Add to dashboard Cite

Cannabidiol (CBD) is a non-psychotomimetic constituent of the Cannabis plant, with potential therapeutic properties for many physical and neuropsychiatric conditions. Isolated CBD has been suggested to have favorable safety and tolerability. Although CBD-related rash is described, few case reports are well documented in the literature, and usually, CBD was used concomitantly with other medications. Thus, we report four women who presented a skin rash after ongoing CBD use. Other causes of these skin rashes were ruled out after conducting an extensive viral and serological detection panel, and three patients had their lesions biopsied. Two patients were re-exposed to the vehicle (MCT) without developing a new skin rash. Therefore, clinicians must be aware of this potential adverse effect of CBD use.

show abstract

Section: Discussionmentioning

confidence: 99%

Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Over the past 50 years, not only has cannabis been increasingly adopted by adolescents and young adults for recreational use, mainly in social settings to increase sociability and produce euphoric and tranquilizing effects [ 34 ], but the age of use initiation is shifting back with younger children and adolescents reporting daily cannabis use [ 35 ]. Although cannabis remains illegal in most countries, there have been significant changes in its use as a therapeutic medicine [ 36 , 37 , 38 ]. Accumulating evidence suggests that some cannabinoids, particularly CBD, may be an effective and safe anxiolytic and potentially also antidepressant agents [ 32 , 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Examining the Use of Antidepressants for Adolescents with Depression/Anxiety Who Regularly Use Cannabis: A Narrative Review

Hen-Shoval

Weller

Weizman

et al. 2022

IJERPH

View full text Add to dashboard Cite

Depression and anxiety disorders are two of the most common and growing mental health concerns in adolescents. Consequently, antidepressant medication (AD) use has increased widely during the last decades. Several classes of antidepressants are used mainly to treat depression, anxiety, and obsessive-compulsive disorders by targeting relevant brain neurochemical pathways. Almost all randomized clinical trials of antidepressants examined patients with no concomitant medications or drugs. This does not address the expected course of therapy and outcome in cannabis users. Cannabis is the most commonly used illicit substance globally. Substantial changes in its regulation are recently taking place. Many countries and US states are becoming more permissive towards its medical and recreational use. The psychological and physiological effects of cannabis (mainly of its major components, tetrahydrocannabinol (THC) and cannabidiol (CBD)) have been extensively characterized. Cannabis use can be a risk factor for depressive and anxiety symptoms, but some constituents or mixtures may have antidepressant and/or anxiolytic potential. The aim of this literature review is to explore whether simultaneous use of AD and cannabis in adolescence can affect AD treatment outcomes. Based on the current literature, it is reasonable to assume that antidepressants are less effective for adolescents with depression/anxiety who frequently use cannabis. The mechanisms of action of antidepressants and cannabis point to several similarities and conjunctions that merit future investigation regarding the potential effectiveness of antidepressants among adolescents who consume cannabis regularly.

show abstract

“…Although researchers are investigating cannabis for treating cancer, psychiatric disorders (13), sleep disorders (14), chronic pain (15) and inflammatory conditions such as rheumatoid arthritis (16), there is currently insufficient evidence to support its clinical use. Scientific studies on emerging therapeutics typically exclude vulnerable populations such as pregnant women, young people, the elderly, and those with comorbidities, and those who depend on multiple medications, thus limiting the availability of evidence for cannabis effectiveness in these population groups (17).…”

Section: Introductionmentioning

confidence: 99%

Social media discourse and internet search queries on cannabis as a medicine: A systematic scoping review

Habibabadi

Bonomo

Conway

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

ObjectiveTo systematically review the current published literature that uses social media data and internet search engine queries to identify emerging themes on the use of cannabis as a medicine. In this study, the term cannabis as a medicine refers to the use of cannabis with therapeutic intent and includes prescribed cannabis, over-the-counter cannabis, and non-prescribed cannabis used specifically for self-medication (not for recreational purposes).Materials and MethodsFor this systematic review, Medline, Scopus, Web of Science and Embase databases were searched for peer reviewed studies published in English between January 2010 and March 2022. All study types that examined social media data and cannabis as a medicine were included in the review.ResultsForty studies were included in this review. 21 studies used manually labeled data, 4 studies used existing meta-data, 2 studies used data from social media analytics companies and 13 used computational methods for annotating data. More than half of the studies 22/40 (55%), were published in the last three years. The incidental use of cannabis as a medicine was found in eleven studies that were focused on more general health-related issues, rather than on medicinal cannabis only.ConclusionOur systematic review has revealed the growing interest in analyzing user-generated content for studying cannabis as a medicine. This review has also highlighted the need for studies into cannabis use for specific health conditions and for automatic processing of larger datasets using computational methods (machine learning technologies).

show abstract

Clinical issues in cannabis use

Cited by 20 publications

References 12 publications

Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations

Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations

Examining the Use of Antidepressants for Adolescents with Depression/Anxiety Who Regularly Use Cannabis: A Narrative Review

Social media discourse and internet search queries on cannabis as a medicine: A systematic scoping review

Contact Info

Product

Resources

About