Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

Mulder, Michelle L M; Hal, Tamara W van; Wenink, Mark H.; Koenen, Hans J. P. M.; Hoogen, F.H.J. van den; Jong, E.M.G.J. de; Reek, J.M.P.A. van den; Vriezekolk, Johanna E

doi:10.1186/s13075-021-02545-4

Cited by 28 publications

(31 citation statements)

References 136 publications

(255 reference statements)

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“…Recent consensus guidelines for managing psoriasis recommend using questionnaires to screen for the presence of PsA, and Salaff et al (176) developed a self-administered questionnaire, called Simple Psoriatic Arthritis Screening (SiPAS), which screens psoriasis patients for signs and symptoms of PsA with compared high sensibility and specificity. In a systematic review, 259 possible markers associated with the development or presence of PsA in patients with psoriasis were identified in 119 studies (177). Laboratory markers related to inflammation and bone metabolism showed a strong association (not prediction) of PsA in psoriasis, however only C-X-C motif ligand 10 reached a strong level of evidence for a positive predictive value (177), but whether these indicators are clinically useful remains to be further investigated.…”

Section: Psamentioning

confidence: 99%

“…In a systematic review, 259 possible markers associated with the development or presence of PsA in patients with psoriasis were identified in 119 studies (177). Laboratory markers related to inflammation and bone metabolism showed a strong association (not prediction) of PsA in psoriasis, however only C-X-C motif ligand 10 reached a strong level of evidence for a positive predictive value (177), but whether these indicators are clinically useful remains to be further investigated.…”

Section: Psamentioning

confidence: 99%

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Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review

et al. 2022

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Psoriasis is a chronic autoimmune inflammatory disease that remains active for a long period, even for life in most patients. The impact of psoriasis on health is not only limited to the skin, but also influences multiple systems of the body, even mental health. With the increasing of literature on the association between psoriasis and extracutaneous systems, a better understanding of psoriasis as an autoimmune disease with systemic inflammation is created. Except for cardiometabolic diseases, gastrointestinal diseases, chronic kidney diseases, malignancy, and infections that have received much attention, the association between psoriasis and more systemic diseases, including the skin system, reproductive system, and oral and ocular systems has also been revealed, and mental health diseases draw more attention not just because of the negative mental and mood influence caused by skin lesions, but a common immune-inflammatory mechanism identified of the two systemic diseases. This review summarizes the epidemiological evidence supporting the association between psoriasis and important and/or newly reported systemic diseases in the past 5 years, and may help to comprehensively recognize the comorbidity burden related to psoriasis, further to improve the management of people with psoriasis.

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Section: Psamentioning

confidence: 99%

Section: Psamentioning

confidence: 99%

Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review

et al. 2022

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“…It has been postulated that the initiation of PsA occurs after triggering by environmental factors in gut, entheses, or skin in patients who are genetically more susceptible to development of this disease (37). The genetics of PsA have been reviewed in detail (38)(39)(40)(41). In short, both HLA and non-HLA coding genes are associated with PsA.…”

Section: Initiation Of Psoriatic Arthritismentioning

confidence: 99%

“…In the non-HLA coding groups genes are related to innate immunity, cytokines (TNF, IFN, and IL-23/17) and antigen processing and presentation (38). However, genes that are specifically associated with development of PsA in PsO patients remain scarce (39). Two HLA-B27 haplotypes (C * 01 and C * 02, respectively) (42,43) and IL13 gene polymorphism were suggested to be independent associated with PsA development in PsO patients (44,45).…”

Section: Initiation Of Psoriatic Arthritismentioning

confidence: 99%

Translational Research Studies Unraveling the Origins of Psoriatic Arthritis: Moving Beyond Skin and Joints

et al. 2021

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Patients with psoriatic arthritis (PsA) are suffering from a decreased quality of life despite currently available treatments. In the latest years, novel therapies targeting the IL-17/IL-23 and TNF pathways improved clinical outcome. Despite this, remission of disease is not achieved in a considerable group of patients, continuous treatment is very often required to reach clinical remission, and prevention of PsA in patients with psoriasis (PsO) is currently impossible. A better understanding of PsA pathogenesis is required to develop novel treatment strategies that target inflammation and destruction more effectively and at an early stage of the disease, or even before clinically manifest disease. The skin is considered as one of the sites of onset of immune activation, triggering the inflammatory cascade in PsA. PsO develops into PsA in 30% of the PsO patients. Influenced by environmental and genetic factors, the inflammatory process in the skin, entheses, and/or gut may evolve into synovial tissue inflammation, characterized by influx of immune cells. The exact role of the innate and adaptive immune cells in disease pathogenesis is not completely known. The involvement of activated IL-17A+ T cells could implicate early immunomodulatory events generated in lymphoid organs thereby shaping the pathogenic inflammatory response leading to disease. In this perspective article, we provide the reader with an overview of the current literature regarding the immunological changes observed during the earliest stages of PsA. Moreover, we will postulate future areas of translational research aimed at increasing our knowledge on the molecular mechanisms driving disease development, which will aid the identification of novel potential therapeutic targets to limit the progression of PsA.

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“…The top 25 most common DEGs in the suprabasal keratinocytes between GSE151177 and GSE162183 both included IL36G , a keratinocyte-derived cytokine known as an important factor in psoriasis pathogenesis ( Figures 3C, D ). The increased presence of IL-36 in was mainly seen in the suprabasal layer of psoriatic epidermis ( Figure 3E , Supplementary Figure 3E ) As strong IL-23R expression is detected in psoriatic epidermis ( 13 ), we presumed that IL-23 might be associated with IL-36 production. We used HaCaT and JurkaT cell lines to check the possible association between IL-23 and IL-36 γ.…”

Section: Resultsmentioning

confidence: 87%

Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in Psoriasis

et al. 2022

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Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in keratinocytes. To determine the presence and potential role of keratinocyte-derived IL-23 in psoriasis, we investigated its expression levels using publicly available single-cell RNA sequencing data from human samples. We discovered that the expression of IL23A was detectable in keratinocytes as well as dendritic cells. Furthermore, we examined the IL-23p19 expression in an imiquimod-induced mouse model of psoriasis and found a close relationship between keratinocyte-produced IL-23 and IL-36, another key cytokine in psoriasis pathogenesis. The blockade of IL-23 signaling resulted in the reduced expression of IL-36 in the keratinocytes. Our findings reveal the novel association between keratinocyte-derived IL-23 and IL-36 in psoriasis progression.

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Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

Cited by 28 publications

References 136 publications

Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review

Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review

Translational Research Studies Unraveling the Origins of Psoriatic Arthritis: Moving Beyond Skin and Joints

Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in Psoriasis

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