Clinical laboratory reference intervals in pediatrics: The CALIPER initiative

Serum ferritin concentration is affected by ferroportin Q248H mutation in Africans

“…Demographic data (age, gender, ethnicity, and lifetime blood donations) were extracted from the donor records. Blood donors are generally considered to be healthy and as such can represent a normal population [14]. The samples were de-identified before inclusion in the study as recommended in ISO: 15189 that "the use of samples for purposes other than requested without prior consent should only occur if the residual samples are rendered anonymous" [15].…”

Reference values of amino acids and of common clinical chemistry in plasma of healthy infants aged 1 and 4 months

“…Recommendations have been made by expert panels of the International Federation of Clinical Chemistry (IFCC) on the theory, production and use of reference intervals (IFCC 1987a, b). Recent guidelines have been approved by the Clinical and Laboratory Standards Institute (CLSI 2013) as well as recommendations for pediatric reference limits (Jung and Khosrow 2009).…”

Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children

“…Many of the challenges encountered when establishing pediatric reference intervals are related to child development and growth, which can profoundly influence the concentrations of many analytes routinely measured in the clinical diagnostic laboratory. Differences in physical size, organ maturity, body fluid compartments, immune and hormone responsiveness, nutrition, and metabolism are likely to affect normal analyte concentrations in children and youth (2,3 ).…”