Clinical magnetocardiography: Experience with a biomagnetic multichannel system

Moshage, Werner; Achenbach, Stephan; Weikl, A; Göhl, K.; Bachmann, K.; Abraham-Fuchs, K.; Härer, Wolfgang; Schneider, Siegfried

doi:10.1007/bf01797754

Cited by 14 publications

(8 citation statements)

References 10 publications

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“…Despite the encouraging results of former studies using a multichannel MCG system inside a shielded setting, the method was limited by the high costs of the system itself. 15,25,28 The present data show the results of a much less expensive single-channel system not requiring a shielded room. A further confirmation of these results in a larger population would be an important step toward the aim of restricting invasive procedures such as coronary angiography to those patients in whom the diagnosis of CAD is confirmed prior to the procedure and in whom interventional therapy appears to be indicated.…”

Section: Discussionsupporting

confidence: 55%

“…[10][11][12][13] However, this method itself is also limited because of the time-consuming procedure of lead placement and registration. Analogous to BSPM, magnetocardiography (MCG) can register cardiac activity at multiple sites over the heart, 14,15 while the signal can be processed and analyzed in a fashion similar to the computerized ECG ( Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

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Magnetocardiography in coronary artery disease with a new system in an unshielded setting

Hailer¹,

Chaikovsky²,

Auth‐Eisernitz³

et al. 2003

Clinical Cardiology

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SummaryBackground: The noninvasive detection of coronary artery disease (CAD) remains a clinical challenge. Magnetocardiography is a completely noninvasive method that permits the registration of cardiac electrical activity at multiple sites in a plane above the chest cage without the need for electrodes. In contrast to the electrocardiogram (ECG) which suffers from boundary effects and a variety of potential artifacts (electrode placement, etc.) the MCG is unaffected by such impediments as the magnetic field is unaltered by surrounding tissues.Hypothesis: Magnetocardiography with a newly developed single-channel system in an unshielded setting should be a better qualitative diagnostic tool than the standard ECG for the detection and assessment of CAD.Methods: In all, 52 patients with angiographically documented CAD and unimpaired ventricular function as well as 55 controls were included in this study. A standard 12-lead ECG was obtained in all subjects. The MCG recordings were taken from 36 positions under resting conditions. From these, current density vector maps were generated during the ST-T interval. Each map was then classified using a classification system with a scale from 0 (normal) to 4 (grossly abnormal).

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Magnetocardiography in coronary artery disease with a new system in an unshielded setting

Hailer¹,

Chaikovsky²,

Auth‐Eisernitz³

et al. 2003

Clinical Cardiology

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“…The magnetic fields both due to electrical stimulation in phantom studies and caused by cardiac excitation in patients (magnetocardiogram, MCG) were recorded with the 37-channel SQUID system Krenikon® (Siemens) inside a magnetically shielded room [9]. The MCG was recorded in supine position of the patient, simultaneous with 12 standard ECG leads and a respiration channel (see Fig.…”

Section: Methodsmentioning

confidence: 99%

“…However, it was not until the availability of multichannel SQUID systems installed in magnetically shielded rooms that the registration quality was sufficient for the development of clinical applications [7][8][9]. Making use of the available technology, we investigated the applicability and accuracy of multichannel magnetocardiographic recordings for non-invasive 3-dimensional localization in phantom and patient studies, by comparison to established reference methods, and, as a gold standard, by the confirmation of localization results through successful high frequency catheter ablation.…”

Section: Introductionmentioning

confidence: 98%

Evaluation of the non-invasive localization accuracy of cardiac arrhythmias attainable by multichannel magnetocardiography (MCG)

et al. 1996

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The accuracy of multichannel magnetocardiography (MCG) for the non-invasive localization of cardiac arrhythmias was investigated. A non-magnetic catheter was used in phantom studies and for cardiac pacing of 6 patients. In a clinical setting, 32 patients with WPW-syndrome, 37 patients with premature ventricular complexes and 12 patients with ventricular tachycardia were studied and the MCG results compared to reference methods, including invasive electrophysiological mapping. Phantom and pacing studies demonstrated the spatial localization accuracy to be better than 15 mm for a dipole-to-dewar distance below 15 cm. In all patients with structural cardiac disease, the ectopic focus was localized at the margin of the damaged area, serving as a proof of MCG localization. Invasive mapping confirmed the MCG result whenever performed (42 patients). In 11 patients (9 WPW, 2 VT) the MCG localization result was verified by successful HF catheter ablation as a gold standard. MCG permits the non-invasive localization of cardiac arrhythmias with high spatial accuracy. MCG guided HF catheter ablation constitutes a new concept of non-invasive localization and minimally invasive causal therapy.

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“…eignisse wie ventrikul~irer Tachykardien koh~irent zu erfassen und biomagnetisch zu lokalisieren[13,14]. Auch wenn die klinische Bedeutung singul~irer ventrikul~irer Extrasystolen gering ist, ist es doch m6glich geworden, aus VES den exit-point ventrikul~irerTachykardienderselben Morphotogie magnetokardiographisch zu lokalisieren [29].…”

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Magnetokardiographische Lokalisationsdiagnositk — Gegenwärtiger Stand und Entwicklungsperspektiven

Moshage

Achenbach

Bachmann

1997

Herzschr Elektrophys

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The magnetic fields caused by the human heart's electrical excitation can be recorded without contact over the body surface to obtain the "magnetocardiogram" (MCG). As compared to the conventional electrocardiogram (ECG), the magnetic fields are influenced far less by the conductive properties of the body tissues, so that the MCG permits a more direct and accurate analysis of cardiac electrical excitation. Most important, the MCG allows an exact localization of the underlying electrical activity, based on the recorded magnetic field distribution. For localization, the MCG does not rely on pattern recognition algorithms such as the ECG, instead, a computational 3-D localization is performed using simplified source and volume conductor models. The spatial accuracy of this method, in combination with magnetic resonance imaging for anatomical assignment of the localization results, has been determined to be 10 to 15 mm for sources close to the body surface and 15 to 20 mm for sources in the posterior parts of the heart.Clinically, the magnetocardiogram can be applied for the non-invasive localization of accessory pathways in Wolff-Parkinson-White syndrome, and of ventricular ectopies (PVC and VT). Especially in combination with a subsequent interventional treatment by catheter ablation, the method may improve the clinical management of these conditions.While the registration techniques are standardized in a way that permits routine clinical application, the data evaluation has to be optimized and simplified before this method can be completely handed over for physicians to use.

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Clinical magnetocardiography: Experience with a biomagnetic multichannel system

Cited by 14 publications

References 10 publications

Magnetocardiography in coronary artery disease with a new system in an unshielded setting

Magnetocardiography in coronary artery disease with a new system in an unshielded setting

Evaluation of the non-invasive localization accuracy of cardiac arrhythmias attainable by multichannel magnetocardiography (MCG)

Magnetokardiographische Lokalisationsdiagnositk — Gegenwärtiger Stand und Entwicklungsperspektiven

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