Clinical management and infection control protocols during the COVID-19 pandemic: An online survey

Rafeeq, Reem Atta; Saleem, Alan E.; Nahidh, Mohammed; Kadhum, Ammar S.; Alhuwaizi, Akram Faisal; Marrapodi, Maria Maddalena; Cicciù, Marco; Minervini, Giuseppe

doi:10.3233/thc-220909

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…This study therefore provides an in-depth overview of the involvement of the O.C. in the transmission, diagnosis, and possible therapeutic strategies against the SARS-CoV-2 virus [213][214][215].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Bellocchio,

Dipalma,

Inchingolo

et al. 2023

Biomedicines

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and aids in the spread of COVID-19. Angiotensin-converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are two of the numerous factors that promote SARS-CoV-2 infection, expressed by O.C. structures, various mucosa types, and the epithelia of salivary glands. A systemic SARS-CoV-2 infection might result from viral replication in O.C. cells. On the other hand, cellular damage of different subtypes in the O.C. might be associated with various clinical signs and symptoms. Factors interfering with SARS-CoV-2 infection potential might represent fertile ground for possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the O.C., finally representing a way to reduce COVID-19 incidence and severity.

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Section: Discussionmentioning

confidence: 99%

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Bellocchio,

Dipalma,

Inchingolo

et al. 2023

Biomedicines

View full text Add to dashboard Cite

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Administration of Clinical COVID-19 Mouthwashing Protocol and Potential Modulation of Pediatric Oral Bacterial Prevalence of Selenomonas noxia: A Pilot Study

Sodhi,

Jiang,

Lin

et al. 2023

Pediatric Reports

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Dental office protocols to combat the SARS-CoV-2 (COVID-19) pandemic include mouth washing for an extended 60 s, thereby reducing detectable oral virus. However, it is unclear whether this protocol has any effects on the newly identified periodontal pathogen and obesity-related bacterium often found among pediatric patients, Selenomonas noxia. To determine if the mouthwash protocol has any measurable effect on S. noxia amongst pediatric patients, clinical pediatric saliva samples were obtained from pediatric patients during routine visits for clinical care and treatment. Using an approved protocol, two saliva samples were collected on the same visit before and after chlorhexidine mouthwash (Sample A, Sample B). The third sample (Sample C) was taken at the recall appointment—usually between two and eight weeks later. A total of n = 97 pre-mouthwash samples, and an equal number of matching post-mouthwash samples (n = 97) were collected, with a small number of matching recall samples (n = 36) that were subsequently collected and identified. The demographic composition of the study sample was analyzed using Chi square statistics. Sample DNA from the matching pre-, post-, and recall collections (Sample A, Sample B, and Sample C) was isolated and screened using qPCR and validated primers, which revealed that 11.1% (n = 4/36) from Sample A tested positive for S. noxia with 0% (n = 0/36) of Sample B testing positive and 13.9% (n = 5/36) of the recall (Sample C) testing positive. In addition, comparative analysis of the qPCR cycle threshold data revealed relatively lower expression (quantity) of S. noxia DNA among the recall samples, as determined by two-tailed t-tests (p=0.004). These data and results provide new evidence for the oral prevalence of S. noxia among pediatric patients, while also demonstrating that the COVID-19 protocol of mouth washing prior to clinical treatment for periods extending up to 60 s may be sufficient to reduce the levels of detectable S. noxia—at least temporarily. More research will be needed to determine whether these effects may be limited to the short- or may exhibit more lasting effects in the long-term.

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Clinical management and infection control protocols during the COVID-19 pandemic: An online survey

Cited by 2 publications

References 35 publications

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Administration of Clinical COVID-19 Mouthwashing Protocol and Potential Modulation of Pediatric Oral Bacterial Prevalence of Selenomonas noxia: A Pilot Study

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