2022
DOI: 10.3390/jpm12010101
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Clinical Management of Chronic Pelvic Pain in Endometriosis Unresponsive to Conventional Therapy

Abstract: Background: Although several treatments are currently available for chronic pelvic pain, 30–60% of patients do not respond to them. Therefore, these therapeutic options require a better understanding of the mechanisms underlying endometriosis-induced pain. This study focuses on pain management after failure of conventional therapy. Methods: We reviewed clinical data from 46 patients with endometriosis and chronic pelvic pain unresponsive to conventional therapies at Puerta de Hierro University Hospital Madrid,… Show more

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Cited by 9 publications
(6 citation statements)
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“…The examination of patients with central sensitization seems to confirm the patient's phenotype (tier 2), reveals the affected compartments, and allows for the proposal of multidisciplinary procedures for pain management [20]. Pain central sensitization guides treatments towards combined therapies for myofascial pain syndrome, as well as neuro-pathic and visceral pain treatments.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The examination of patients with central sensitization seems to confirm the patient's phenotype (tier 2), reveals the affected compartments, and allows for the proposal of multidisciplinary procedures for pain management [20]. Pain central sensitization guides treatments towards combined therapies for myofascial pain syndrome, as well as neuro-pathic and visceral pain treatments.…”
Section: Discussionmentioning
confidence: 99%
“…Data from the examination were collected according to the pain mapping method reported in previously published works [19,20], including the following.…”
Section: Exploratory Procedures or Pain Mapping Methodsmentioning
confidence: 99%
“…However, it is estimated that around 30% to 60% of patients do not respond to conventional therapies, including surgery. Hence, there is a current recommendation to shift the approach of endometriosis treatment towards an immune and inflammatory environment surrounding endometrial implant modifications that are currently being developed (11). It is predicted to have a significant impact on symptom management along with disease burden for endometriosis patients worldwide (12).…”
Section: Discussionmentioning
confidence: 99%
“…13 En pequeños estudios aleatorizados no se ha demostrado que la sertralina tenga efecto analgésico sobre el placebo para el tratamiento del dolor pélvico crónico 14 la mayoría de las pacientes presentan dolores mixtos y requieren de terapias combinadas. 15 La mayoría de las pacientes presentan retraso de años para recibir un tratamiento adecuado para la endometriosis profunda, mermando significativamente su calidad de vida. El objetivo de este estudio es evaluar la mejoría clínica de las pacientes posterior a la cirugía laparoscópica de remoción de endometriosis profunda y tratamiento médico con neuromoduladores.…”
Section: Discussionunclassified