Clinical Management of Pain in Advanced Lung Cancer

Simmons, Claribel; MacLeod, Nicholas; Laird, Barry

doi:10.4137/cmo.s8360

Cited by 54 publications

(35 citation statements)

References 138 publications

(205 reference statements)

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“…Chemotherapy is very seldom considered in the targeted treatment of metastatic spinal tumors due to its systemic nature and also owing to the fact that it requires an extended course of administration prior to pain relief. Complications are the source of morbidity and fear for the patient and include pain, gastrointestinal abnormalities, hematological disturbances, immunosupression, and biopsychosocial sequelae (alopecia and infertility).…”

Section: Radiologymentioning

confidence: 99%

Spinal Metastatic Disease: A Review of the Role of the Multidisciplinary Team

Curtin

Piggott

Murphy

et al. 2017

Orthopaedic Surgery

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Historically, a simple approach centered on palliation was applicable to the majority of patients with metastatic spinal disease. With advances in diagnosis and treatment, a more complicated algorithm has devolved requiring a multidisciplinary approach with institutional commitment and support. We performed a database review including pertinent articles exploring the multidisciplinary management of spinal metastatic disease. The wide variation in clinical presentation and tumor response to treatment necessitates a multidisciplinary approach that integrates the diagnosis and treatment of the cancer, symptom management, and rehabilitation for optimal care of patients with spinal metastases. Advances in the field of radiology have led to earlier and more focused diagnosis of spinal metastasis and acts to guide therapy. Advances in surgical techniques, neurophysiologic monitoring, and anesthetic expertise have allowed surgeons to perform more extensive procedures leading to improved outcomes and reduced morbidity. Radiation oncology input that is essential as external beam radiation therapy can provide significant pain relief. Non-operative measures may include bisphosphonate infusions, management of complications (e.g. hypercalcemia of malignancy), monoclonal antibody infusions, and chemotherapy if indicated in the treatment of the primary malignancy. Input from psychology services is necessary to address the biopsychosocial ramifications of spinal metastasis. Allied health professionals in the form of physiotherapists, social workers, and dieticians also contribute in maximizing patients' quality of life and well-being.

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Section: Radiologymentioning

confidence: 99%

Spinal Metastatic Disease: A Review of the Role of the Multidisciplinary Team

Curtin

Piggott

Murphy

et al. 2017

Orthopaedic Surgery

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“…Lung cancer patients experience more symptom distress than any other cancer patients (Caraceni and Portenoy, 1999; Cooley, 2000; Simmons et al, 2012). The pain is characterized into acute pain or chronic pain, which usually differ by duration of pain and predictability (Carr and Goudas, 1999).…”

Section: Current Clinical Management Of Lung Cancermentioning

confidence: 99%

Erlotinib Resistance in Lung Cancer: Current Progress and Future Perspectives

Tang¹,

Salama²,

Gadgeel³

et al. 2013

Front. Pharmacol.

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Lung cancer is the most common cancer in the world. Despite modern advancements in surgeries, chemotherapies, and radiotherapies over the past few years, lung cancer still remains a very difficult disease to treat. This has left the death rate from lung cancer victims largely unchanged throughout the past few decades. A key cause for the high mortality rate is the drug resistance that builds up for patients being currently treated with the chemotherapeutic agents. Although certain chemotherapeutic agents may initially effectively treat lung cancer patients, there is a high probability that there will be a reoccurrence of the cancer after the patient develops resistance to the drug. Erlotinib, the epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor, has been approved for localized as well as metastatic non-small cell lung cancer where it seems to be more effective in patients with EGFR mutations. Resistance to erlotinib is a common observation in clinics and this review details our current knowledge on the subject. We discuss the causes of such resistance as well as innovative research to overcome it. Evidently, new chemotherapy strategies are desperately needed in order to better treat lung cancer patients. Current research is investigating alternative treatment plans to enhance the chemotherapy that is already offered. Better insight into the molecular mechanisms behind combination therapy pathways and even single molecular pathways may help improve the efficacy of the current treatment options.

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“…Lung cancer is the most common cancer in the world with 1.61 million new cases diagnosed every year (Simmons et al, 2012). Currently, about half of all lung cancer patients are diagnosed at early stages (Stage I to III).…”

Section: Introductionmentioning

confidence: 99%

“…Pain can also be affected by the histological type and biological behaviour of the lung cancer present. Pain in patients with lung cancer can be differentiated according to its origin, namely intra-thoracic or extra-thoracic, the latter of which may be the consequence of cancer complications (Sansom-Daly et al, 2012;Simmons et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Cognitive Behavioral Therapy Techniques for Control of Pain in Lung Cancer Patients: An Integrated Review

Phianmongkhol

Thongubon²,

Woottiluk³

2015

Asian Pacific Journal of Cancer Prevention

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Background: Experience of lung cancer includes negative impacts on both physical and psychological health. Pain is one of the negative experiences of lung cancer. Cognitive behavioral therapy techniques are often recommended as treatments for lung cancer pain. The objective of this review was to synthesize the evidence on the effectiveness of cognitive behavioral therapy techniques in treating lung cancer pain. This review considered studies that included lung cancer patients who were required to 1) be at least 18 years old; 2) speak and read English or Thai; 3) have a life expectancy of at least two months; 4) experience daily cancer pain requiring an opioid medication; 5) have a positive response to opioid medication; 6) have "average or usual" pain between 4 and 7 on a scale of 0-10 for the day before the clinic visit or for a typical day; and 7) able to participate in a pain evaluation and treatment program. This review considered studies to examine interventions for use in treatment of pain in lung cancer patients, including: biofeedback, cognitive/attentional distraction, imagery, hypnosis, and meditation. Any randomized controlled trials (RCTs) that examined cognitive behavioral therapy techniques for pain specifically in lung cancer patients were included. In the absence of RCTs, quasi-experimental designs were reviewed for possible conclusion in a narrative summary. Outcome measures were pain intensity before and after cognitive behavioural therapy techniques. The search strategy aimed to find both published and unpublished literature. A three-step search was utilised by using identified keywords and text term. An initial limited search of MEDLINE and CINAHL was undertaken followed by analysis of the text words contained in the title and abstract, and of the index terms used to describe the article. A second search using all the identified keywords and index terms was then undertaken across all included databases. Thirdly, the reference list of all identified reports and articles were searched for additional studies. Searches were conducted during January 1991-March 2014 limited to English and Thai languages with no date restriction. Materials and Methods: All studies that met the inclusion criteria were assessed for methodological quality by three reviewers using a standardized critical appraisal tool from the Joanna Briggs Institute (JBI). Three reviewers extracted data independently, using a standardized data extraction tool from the Joanna Briggs Institute (JBI). Ideally for quantitative data meta-analysis was to be conducted where all results were subject to double data entry. Odds ratios (for categorical data) and weighted mean differences (for continuous data) and their 95% confidence intervals were to be calculated for analysis and heterogeneity was to be assessed using the standard Chi-square. Where statistical pooling was not possible the finding were be presented in narrative form. Results: There were no studies located that met the inclusion requirements of this review. There were al...

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Clinical Management of Pain in Advanced Lung Cancer

Cited by 54 publications

References 138 publications

Spinal Metastatic Disease: A Review of the Role of the Multidisciplinary Team

Spinal Metastatic Disease: A Review of the Role of the Multidisciplinary Team

Erlotinib Resistance in Lung Cancer: Current Progress and Future Perspectives

Effectiveness of Cognitive Behavioral Therapy Techniques for Control of Pain in Lung Cancer Patients: An Integrated Review

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