Clinical manifestation and prognosis of active ocular toxoplasmosis in Iran

Abstract

Toxoplasmosis is the most common cause of posterior uveitis in the world. This study described the clinical characteristics and visual outcome of 193 patients with ocular toxoplasmosis at Feiz Hospital (Isfahan, Iran) during the last six years. The setting and design used was a retrospective non-comparative observational case series. In this study, 193 patients with ocular toxoplasmosis (111 female, 82 male) were enrolled. The distribution of symptoms and fundoscopic findings were studied. The most-reported chief complaint was blurred vision in 96 % (184 patients) and floaters in 13.47 % (25 patients) of cases and most frequent clinical manifestations were chorioretinitis 98.48 % (190 patients), macular scars 50.7 % (98 patients), and atrophic optic papilla two (1.03 %) patients. Primary retinal lesions were observed in 16 (8.2 %) and combination of active lesions and old retinochoroidal scars in 177 (91.7 %) of the patients. Retinal detachment occurred in 11 (5.69 %) patients. Bilateral involvement was found in 27 % of patients. Blindness was 0.05 % after treatment. Recurrence rate was 14.5 %. In conclusion, ocular toxoplasmosis substantially varies among patients with different age, gender, site of lesion and other factors. Suddenly blurred vision, floater, and pain could be caused by Toxoplasma gondii. Flashing, may necessitate a more precise peripheral fundus examination.

Presumed Ocular Toxoplasmosis In University Of Uyo Teaching Hospital, Uyo, Nigeria

“…This is consistent with the study in Iran by Kianersi 6 where 96% of patients complained of diminution of vision and 13.47% of floaters. Ten of our patients (33.5%) had signs and symptoms of vitritis, 2 (6.5%) anterior uveitis.…”

“…Signs and symptoms of anterior uveitis may coexist in patient with posterior uveitis secondary to ocular toxoplasmosis. Eighty three percent (83.3%) of the lesion was uniocular and 16.7% binocular as seen in many other studies 6,7 . Most of the lesion 15(48.4%) affected the posterior pole as seen in other studies 7,9 .…”

“…This may be because the males are those involved in cattle rearing and abattoir work in Northern Nigeria. A study in Iran by Kianersi 6 had 57.5%females and 42.5% males. The age range was between 9-82years with a mean of 41.47years.…”

Evaluation of Cystoid Change Phenotypes in Ocular Toxoplasmosis Using Optical Coherence Tomography

“…As shown in our study, out of a total of 80 eyes with ocular toxoplasmosis with SD-OCT examinations, 6 eyes were present with CME. Although with the application of SD-OCT, more eyes with CME probably could have been detected, our study had shown that CME is still rather uncommon [14] , [15] , [16] .…”

“…FA has been the traditional gold standard for the detection of CME in the past years; however, with the advent of OCT, more CME could be possibly observed with better reproducibility [8], [13]. Although CME in ocular toxoplasmosis was reported in previous publications, none of them evaluated CME with SD-OCT [14], [15], [16]. Thus, in the current study, we tried to use SD-OCT to maximize the detection of CME.…”