Clinical Manifestations and Diagnosis of Axial Spondyloarthritis

Walsh, Jessica A.; Magrey, Marina

doi:10.1097/rhu.0000000000001575

Cited by 47 publications

(21 citation statements)

References 192 publications

(527 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The US age-adjusted prevalence of HLA-B27 is 6.1%, but is lower in African-Americans (1.1%) and Hispanics (4.6%) [14] . The absence of HLA-B27 positivity does not rule out a diagnosis [44] . CRP and ESR levels should also be considered [45] .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Nonradiographic axial spondyloarthritis: expanding the spectrum of an old disease

Magrey

Schwartzman²,

Peyrecave

et al. 2022

Medicine

Self Cite

View full text Add to dashboard Cite

Nonradiographic axial spondyloarthritis (nr-axSpA) represents a distinct phenotype within the spectrum of axial spondyloarthritis (axSpA), which is characterized by a range of clinical manifestations. Despite a high disease burden that is comparable to ankylosing spondylitis (also known as radiographic axSpA), there is an unmet need to recognize and effectively manage patients with active nr-axSpA.A targeted literature search was conducted in OVID (MEDLINE and Embase databases) to identify articles on nr-axSpA, including its definition, demographics, epidemiology, burden, diagnosis, clinical presentation, and treatment guidelines.The lack of adequate epidemiological data and incomplete understanding of nr-axSpA among rheumatologists and nonrheumatologists contributes to delayed referrals and diagnosis. This delay results in a substantial burden on patients, physically and psychologically, and the healthcare system. Targeted therapies, such as biologics, including inhibitors of tumor necrosis factor or interleukin-17A, have been approved and utilized for the management of nr-axSpA, and other novel therapeutics with different mechanisms of action are in development. Raising awareness among US internists regarding the prevalence of nr-axSpA, disease burden, clinical presentation, diagnostic tools, and available treatments is important for improved disease management.Future clinical investigations focusing on the development of markers that aid early diagnosis and predict treatment response may also improve the management of nr-axSpA. This review provides an overview of nr-axSpA with the aim of raising awareness of the disease among US internists, with an overarching goal to contribute toward the improved recognition and timely referral of these patients to rheumatologists for diagnosis and management.

show abstract

Section: Resultsmentioning

confidence: 99%

“…[ 14 ] The absence of HLA-B27 positivity does not rule out a diagnosis. [ 44 ] CRP and ESR levels should also be considered. [ 45 ] Globally, lower CRP and ESR levels are seen in patients with nr-axSpA than AS.…”

Section: Resultsmentioning

confidence: 99%

Nonradiographic axial spondyloarthritis: expanding the spectrum of an old disease

Magrey

Schwartzman²,

Peyrecave

et al. 2022

Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cauda equina syndrome, which is a serious pathology that usually develops in relation to large central disc hernias, is seen in less than 1% of patients with low back pain and is a rare cause of low back pain in the primary care setting. In these patients, muscle weakness, saddle-style anesthesia, bladder, and bowel dysfunction can be seen [8].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic approach to low back pain

Reşorlu

2023

Family Practice and Palliative Care

View full text Add to dashboard Cite

Low back pain is an important cause of pain referrals in the primary care setting. Overall, 85% of initial admissions are considered to be nonspecific low back pain that resolves in a few weeks without the need for additional evaluation. Myofascial pain, lumbar disc herniation, spinal stenosis, facet joint and disc degeneration, and sacroiliac joint pathologies are common causes of mechanical low back pain. Non-mechanical low back pain includes infections of the vertebral corpus and disc, malignant tumors and metastases, and inflammatory diseases. Red flag symptoms suggestive of serious diseases should be evaluated in all patients with low back pain, and the diagnosis process should be accelerated in patients with these symptoms. The so-called "yellow flags" associated with chronic low back pain include psychosocial factors. In the diagnosis process, pain relief is observed in patients with non-specific low back pain without the need for imaging methods. Laboratory tests and imaging methods can be used to distinguish other causes of low back pain.

show abstract

“…Spondyloarthritis (SpA) comprises a group of chronic immune-mediated inflammatory conditions with overlapping clinical and genetic features but with substantial heterogeneity, as inflammation can affect peripheral and axial joints and also result in extraarticular manifestations (enthesitis, dactylitis, uveitis, inflammatory bowel disease, psoriasis) [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis

Diaconu

Ceasovschih

Șorodoc

et al. 2022

IJMS

View full text Add to dashboard Cite

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis by secondary ossification of inflammatory lesions, with progressive disability and a significant impact on quality of life. It is also a risk factor for the occurrence of comorbidities, especially cardiovascular diseases (CVDs), mood disorders, osteoporosis, and malignancies. Early diagnosis and treatment are needed to prevent or decrease functional decline and to improve the patient’s prognosis. In respect of axSpA, there is an unmet need for biomarkers that can help to diagnose the disease, define disease activity and prognosis, and establish personalized treatment approaches. The aim of this review was to summarize the available information regarding the most promising biomarkers for axSpA. We classified and identified six core categories of biomarkers: (i) systemic markers of inflammation; (ii) molecules involved in bone homeostasis; (iii) HLA-B27 and newer genetic biomarkers; (iv) antibody-based biomarkers; (v) microbiome biomarkers; and (vi) miscellaneous biomarkers. Unfortunately, despite efforts to validate new biomarkers, few of them are used in clinical practice; however, we believe that these studies provide useful data that could aid in better disease management.

show abstract

Clinical Manifestations and Diagnosis of Axial Spondyloarthritis

Cited by 47 publications

References 192 publications

Nonradiographic axial spondyloarthritis: expanding the spectrum of an old disease

Nonradiographic axial spondyloarthritis: expanding the spectrum of an old disease

Diagnostic approach to low back pain

Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis

Contact Info

Product

Resources

About