Clinical Manifestations and Factors Associated with Osteosarcopenic Obesity Syndrome: A Cross-Sectional Study in Koreans with Obesity

Kim, Yoo Mee; Kim, Sung Hoon; Won, Young Jun; Kim, Se Hwa

doi:10.1007/s00223-019-00551-y

Cited by 25 publications

(44 citation statements)

References 32 publications

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“…When it was first identified in 2014 [12] and coined as osteosarcopenic obesity (OSO), it was described as a syndrome in Caucasian aging women [39,40] and linked to their lower functional performance [41]. Subsequently, it has been recognized and studied throughout the world in different populations, including Koreans [42][43][44][45], Chinese [46][47][48], Mexicans [49], Brazilians [50,51], Italians [52], and most strikingly, it was even identified in Greek young (18-20 years) obese men and women [53]. Other studies have linked OSO with various other ill consequences, including cancer and kidney disease; see review [22].…”

Section: Osteosarcopenic Adiposity (Osa) As a Model For Studying And mentioning

confidence: 99%

Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation

Ilich

Gilman²,

Cvijetić

et al. 2020

Nutrients

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Chronic stress and low-grade chronic inflammation (LGCI) are key underlying factors for many diseases, including bone and body composition impairments. Objectives of this narrative review were to examine the mechanisms by which chronic stress and LGCI may influence osteosarcopenic adiposity (OSA) syndrome, originally named as ostoesarcopenic obesity (OSO). We also examined the crucial nutrients presumed to be affected by or cause of stress and inflammation and compared/contrasted them to those of our prehistoric ancestors. The evidence shows that stress (particularly chronic) and its related inflammatory processes, contribute to osteoporosis, sarcopenia, and adiposity ultimately leading to OSA as a final and most deranged state of body composition, commencing at the mesenchymal cell lineage disturbance. The foods/nutrients consumed by modern humans, as well as their altered lifestyle, also contribute to stress, LGCI and subsequently to OSA. The processes can also go in opposite direction when stress and inflammation impact nutritional status, particularly some micronutrients’ levels. While nutritional management of body composition and LGCI have been studied, the nutrients (and their quantities) most affected by stressors and those which may act toward the alleviation of stressful state, ultimately leading to better body composition outcomes, need to be elucidated.

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Section: Osteosarcopenic Adiposity (Osa) As a Model For Studying And mentioning

confidence: 99%

Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation

Ilich

Gilman²,

Cvijetić

et al. 2020

Nutrients

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“…However, the current association of OSO and physical performance studies only focus on older women. 19,20,23 Therefore, this study aims to investigate the relationship between OSO and physical performance (grip strength, 4-m walk test (WS), TUGT) in community-dwelling older men and women. The study is meaningful because after 2012, more than 70% of China's elderly people lived in suburban counties.…”

Section: Introductionmentioning

confidence: 99%

<p>Osteosarcopenic Obesity Associated with Poor Physical Performance in the Elderly Chinese Community</p>

Ma¹,

Wen²,

Han³

et al. 2020

CIA

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The aims of this study were to investigate the association between osteosarcopenic obesity (OSO) and physical performance in Chinese elderly communities. Methods: Our study population is comprised of residents of the Township Central Hospital in the suburban of Tianjin, China. Participants (n=303; percent body fat (PBF): ≥25% for men and ≥32% for women) were assessed using the direct segmental multi-frequency bioelectrical impedance analysis (BIA) for body composition. Sarcopenia was defined as the lower 20th percentile of appendicular skeletal muscle mass/height 2 (ASMI). A quantitative ultrasound scan of each participants' calcaneus with a T score≤−1.0 was used to identify the prevalence of osteopenia/osteoporosis (OP). We divided people into four groups: obesity only (O), osteopenic obesity (OO), sarcopenic obesity (SO), and osteosarcopenic obesity (OSO). We assessed the physical performance by grip strength, 4-m walk test (WS) and timed up and go test (TUGT). Results: A total of 303 participants had completed data (89 men, 214 women; mean age of 68.8 ±6.0 years). The prevalence of OSO was 10.2% (men: 15.70%, women: 7.9%). After multiple adjustments, WS was significantly declined in OSO group when compared with the O group in men (mean value 95% CI was 0.84 (0.69, 0.99)) and women (mean value 95% CI was 0.93 (0.84, 1.02)). TUGT was significantly poorer in men (mean value 95% CI was 13.3 (10.6, 15.9)) and women (mean value 95% CI was 12.4 (11.2, 13.7)) with OSO when compared with the O group. Furthermore, the OSO group in women also had a significantly poorer TUGT compared with the OO group. The result of grip strength decreased significantly in women SO and OSO groups when compared with the O group (mean value 95% CI was 16.4 (14.5, 18.2) and 16.1 (13.9, 18.3)). But the results of grip strength in men showed no significant differences in any of the group. Conclusion: In Chinese community-dwelling elderly, slower WS and lower balance function were associated with OSO in men and women. Lower grip strength was associated with SO and OSO in women.

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“…A total of N = 37,124 individuals (66% women) aged 50 to 94 years were included. Eight studies included women only, 20,22,24,26,27,30,42,44 two included men only, 14,25 and 16 included both men and women 21,23,28,29,31–41,43 . Twenty studies were cross‐sectional in design, 20,22–25,28–38,41–44 and six studies were cohort studies 14,21,26,27,39,40 .…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies included women only, 20,22,24,26,27,30,42,44 two included men only, 14,25 and 16 included both men and women 21,23,28,29,31–41,43 . Twenty studies were cross‐sectional in design, 20,22–25,28–38,41–44 and six studies were cohort studies 14,21,26,27,39,40 . Twenty‐five studies included community‐dwelling older adults, 14,20–35,37–44 and one study was conducted in hospitalized older adults 36 .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty studies were cross‐sectional in design, 20,22–25,28–38,41–44 and six studies were cohort studies 14,21,26,27,39,40 . Twenty‐five studies included community‐dwelling older adults, 14,20–35,37–44 and one study was conducted in hospitalized older adults 36 . Obesity was defined by body mass index (BMI) in five studies, 24,25,29,34,37 by body fat percentage in 17 studies, 14,20,22,23,26,28,30,31,33,35,36,38–43 and by waist circumference in four studies 21,27,32,44 .…”

Section: Resultsmentioning

confidence: 99%

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Falls, fractures, and areal bone mineral density in older adults with sarcopenic obesity: A systematic review and meta‐analysis

et al. 2021

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Summary Sarcopenia and obesity are common conditions in older adults that may have differing effects on falls and fracture risk. This systematic review and meta‐analysis aimed to determine whether older adults with sarcopenic obesity have increased risk of falls and fractures or lower bone mass compared with older adults with sarcopenia, obesity, or neither condition. Twenty‐six studies (n = 37,124) were included in the systematic review and 17 (n = 31,540) were included in the meta‐analysis. Older adults with sarcopenic obesity had lower femoral neck areal bone mineral density (aBMD) compared with those with obesity alone but had higher femoral neck aBMD compared with counterparts with sarcopenia alone (both P < 0.05). Older adults with sarcopenic obesity had higher nonvertebral fracture rates (incidence rate ratio: 1.88; 95% confidence intervals: 1.09, 3.23; based on two studies), compared with those with sarcopenia alone, and also had higher falls risk compared with controls (risk ratio: 1.30; 95% confidence intervals: 1.10, 1.54) and obesity alone (risk ratio: 1.17; 95% confidence intervals: 1.01, 1.36). In conclusion, this systematic review and meta‐analysis has demonstrated that older adults with sarcopenic obesity are at increased risk of adverse musculoskeletal outcomes compared with individuals with obesity, sarcopenia, or neither condition. These data support the need for developing interventions to improve bone health and physical function in this population.

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Clinical Manifestations and Factors Associated with Osteosarcopenic Obesity Syndrome: A Cross-Sectional Study in Koreans with Obesity

Cited by 25 publications

References 32 publications

Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation

Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation

<p>Osteosarcopenic Obesity Associated with Poor Physical Performance in the Elderly Chinese Community</p>

Falls, fractures, and areal bone mineral density in older adults with sarcopenic obesity: A systematic review and meta‐analysis

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