Clinical Manifestations and Implications of Nonneoplastic Uveitis Masquerade Syndrome

Hsu, Yung-Ray; Wang, Ling-Uei; Chen, Fang-Ting; Wang, Jia-Kang; Huang, Tzu-Lun; Chang, Po‐Yuan; Chen, Yun‐Ju

doi:10.1016/j.ajo.2021.12.018

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…Clues to the presence of UMS may be atypical findings on exam and ocular imaging, and inadequate responses to immunosuppression. The transient steroid responsiveness of some UMS, especially lymphomas, can pose profound diagnostic challenges [32][33][34][35].…”

Section: Uveitis By Etiologymentioning

confidence: 99%

Inflammatory eye disease for rheumatologists

Corbitt

Nowatzky

2023

Current Opinion in Rheumatology

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Purpose of reviewThis review provides a framework for understanding inflammatory eye disease diagnosis, differential diagnosis, and management for rheumatologists. Uveitis, scleritis, episcleritis, peripheral ulcerative keratitis, and orbital inflammation are all discussed. The goal is to facilitate the development of approaches to inflammatory eye diseases that will help rheumatologists co-manage these patients with eye care providers specializing in ocular inflammation.Recent findingsIn recent years, studies have aimed to advance biologic treatments and define standard-of-care therapy. Inflammatory eye diseases are highly heterogeneous and often rare, which poses significant challenges to their research and the interpretation of existing data. To date, glucocorticoids, mycophenolate, methotrexate, and TNF inhibitors remain the mainstay of treatment options for many of these diseases.SummaryPatients with inflammatory eye diseases require multidisciplinary care for best outcomes, frequently including rheumatologists. Understanding the differentials, diagnostics, and treatment are essential to preserving vision in these patients. The diverse nature of the disease processes within this field requires focusing on specific disease phenotypes and endotypes in research and clinical practice.

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Section: Uveitis By Etiologymentioning

confidence: 99%

Inflammatory eye disease for rheumatologists

Corbitt

Nowatzky

2023

Current Opinion in Rheumatology

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“…Severe intraocular inflammation commonly results in subretinal fluid and hypotony as a prominent feature. However, chronic rhegmatogenous retinal detachments, are known to exhibit features of inflammation such as hypotony and even intense anterior chamber inflammation with fibrin and secclusio pupillae 63,66 due to secondary release of proinflammatory cytokines. 67 Identifying breaks in the peripheral retina can be challenging due to vitreous haze and poor pupillary dilation due to posterior synechiae.…”

Section: Rhegmatogenous Retinal Detachmentmentioning

confidence: 99%

“…There are numerous non‐neoplastic entities which may have a degree of intraocular inflammation as part of their clinical picture but are not caused by primary intraocular inflammation. The long list of differential diagnoses (Table 2) includes retained intraocular foreign body, rhegmatogenous retinal detachment, infectious endophthalmitis, uveal effusion syndrome, retinal vascular disease (e.g., ocular ischaemic syndrome, radiation retinopathy) and inherited retinal disease 63,64 . Misdiagnosis and long‐term immunosuppressive therapy in these conditions hinders appropriate management and in cases of infectious aetiologies, may result in poor clinical outcomes.…”

Section: Non‐neoplastic Masqueradesmentioning

confidence: 99%

Uveitis masquerade syndromes: An approach to diagnosis

Lin,

Hall

2023

Clinical Exper Ophthalmology

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Uveitis masquerade syndromes are a diverse group of clinical entities which mimic conventional immune‐mediated uveitis due to the presence of inflammatory signs but are resistant to anti‐inflammatory therapy. Misdiagnosis hinders appropriate management in these conditions and may result in poor outcomes. This review discusses commonly encountered neoplastic and non‐neoplastic disease processes that masquerade as intraocular inflammation with a focus on relevant clinical features and adjunctive investigations that are helpful in reaching a correct diagnosis.

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“…Some tumors and retinal degenerations can masquerade as uveitis. [ 5 ] A correct and tailored set of investigations will help to narrow down and identify the etiology of both ocular and underlying systemic conditions.…”

Section: Introductionmentioning

confidence: 99%

Clinical association and visual morbidity in uveitis with systemic diseases: An analysis from a tertiary ophthalmic center

Annamalai,

Mahesh,

Biswas

2023

Oman Journal of Ophthalmology

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AIM: The aim of this study was to identify the incidence, etiology, most common presentations, complications, and the causes of visual loss in posterior uveitis (PU). MATERIALS AND METHODS: A retrospective study was conducted on a cohort of 125 patients with PU with a minimum follow-up of 6 months. Ocular evaluation consisted of slit-lamp examination, indirect ophthalmoscopy, tonometry, and refraction. Ancillary ophthalmic investigations such as fundus fluorescein angiography, optical coherence tomography, and B-scan ultrasonography were done. Laboratory tests were performed on blood on all patients and in aqueous humor samples obtained by anterior chamber paracentesis in cases of diagnostic dilemmas. All the data were analyzed using SPSS program. RESULTS: PU occurred in 61%. Infections were noted in 34% and autoimmune diseases in 27%. The most frequent presentation was choroiditis. The most common etiologies were tubercular uveitis in 50%, Toxoplasma retinochoroiditis in 23%, and autoimmune category of serpiginous choroiditis in 56% of patients. Complications occurred in 27% and were most commonly cystoid macular edema and macular scarring. Polymerase chain reaction (PCR), nested PCR, and real-time PCR on ocular fluids were required for diagnosis in 30%. A combination of laboratory investigations on blood and aqueous humor samples were confirmation in 88%. CONCLUSION: PU and its sequelae are known to be sight threatening and are associated with systemic diseases. They have diverse etiologies and presentations. Identification of etiology is important as management is diametrically opposite in infections and autoimmune diseases.

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Clinical Manifestations and Implications of Nonneoplastic Uveitis Masquerade Syndrome

Cited by 4 publications

References 31 publications

Inflammatory eye disease for rheumatologists

Inflammatory eye disease for rheumatologists

Uveitis masquerade syndromes: An approach to diagnosis

Clinical association and visual morbidity in uveitis with systemic diseases: An analysis from a tertiary ophthalmic center

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