Clinical Manifestations and Mechanism of the Haemorrhagic Diathesis in Marburg Virus Disease

Egbring, R; Slenczka, Werner; Baltzer, G.; Wolff, G.

doi:10.1007/978-3-662-01593-3_6

Cited by 28 publications

(14 citation statements)

References 7 publications

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“…In nonhuman primate models of EHF, disseminated intravascular coagulation is noted by the second day post-infection, as evidenced by the appearance of d-dimers in the plasma (Geisbert et al, 2003c). Extensive necrosis is noted, especially in the liver, although it is usually not to a degree to account for death (Egbring et al, 1971;Martini, 1971;Stille and Bohle, 1971;Gear et al, 1975;Geisbert and Jaax, 1998;Zaki and Goldsmith, 1999). Although endothelial cell infection is consistently noted on post-mortem tissues collected from filovirus victims (Zaki and Goldsmith, 1999), studies in nonhuman primates suggest that this does not occur until late in the course of the disease (Geisbert et al, 2003d).…”

Section: Pathogenesismentioning

confidence: 99%

“…The presenting symptoms are difficult to distinguish from a host of other febrile illnesses. After an incubation period of around 8 days (range 3-21 days), disease typically begins with the abrupt onset of fever, chills, headache, general malaise, anorexia, sore throat, and chest, back, muscle, and joint pains (Martini et al, 1968;Egbring et al, 1971;Martini, 1971;Stille D.G. Bausch et al / Antiviral Research 78 (2008) 150-161 153 and Bohle, 1971;Todorovitch et al, 1971;Gear et al, 1975;Pattyn et al, 1977;Anon., 1978;Smith et al, 1982;Nikiforov et al, 1994;Johnson et al, 1996;Bwaka et al, 1999;Bausch et al, 2006;Colebunders et al, 2007).…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Common clinical laboratory findings include WBC abnormalities (moderate leucopenia and lymphopenia with atypical lymphocytes early in the course of disease, with late leukocytosis and left shift), hemoconcentration, mild-to-moderate thrombocytopenia, blood coagulation abnormalities consistent with disseminated intravascular coagulopathy, and elevated hepatic transaminases (typically AST > ALT), amylase, blood urea nitrogen, and creatinine (Egbring et al, 1971;Martini, 1971;Stille and Bohle, 1971;Gear et al, 1975;. Radiographic examination has not been reported.…”

Section: Clinical Presentationmentioning

confidence: 99%

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Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions

et al. 2008

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The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks. In recent years, laboratory research on the filoviruses has produced treatments and vaccines that are effective in laboratory animals and that could potentially drastically reduce case-fatality rates and curtail outbreaks in humans. However, there are significant challenges in clinical testing of these products and eventual delivery to populations in need. Most cases of filovirus infection are recognized only in the setting of large outbreaks, often in the most remote and resource-poor areas of sub-Saharan Africa, with little infrastructure and few personnel experienced in clinical research. Significant political, legal, and socio-cultural barriers also exist. Here, we review the present research priorities and environment for field study of the filovirus hemorrhagic fevers and outline a strategy for future prospective clinical research on treatment and vaccine prevention.

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Section: Pathogenesismentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

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Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions

et al. 2008

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“…In specific infections, such as viral HF, bleeding complications are prominent [18][19][20]. Among the viral HFs, Dengue [18][19][20], Marburg [21,22], and Ebola [23,24] are the most important. Dengue is the most prevalent (table 1).…”

Section: Clinical Aspects Of Hemostasis In Bacterial and Viral Infectmentioning

confidence: 99%

Review: Infectious Diseases and Coagulation Disorders

et al. 1999

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Infection, both bacterial and nonbacterial, may be associated with coagulation disorders, resulting in disseminated intravascular coagulation and multiorgan failure. In the last few decades a series of in vivo and in vitro studies has provided more insight into the pathogenetic mechanisms and the role of cytokines in these processes. Because of the growing interest in this field, the complexity of the subject, and the fact that many physicians must deal with a variety of infections, current data are reviewed on the association between infectious diseases and the coagulation system. Novel therapeutic intervention strategies that will probably become available in the near future are mentioned, along with those of special interest for infectious disorders for which only supportive care can be given.

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“…In most instances, a diagnosis of DIC can be made by taking into consideration the underlying disease in conjunction with a combination of laboratory findings (Levi et al, 1999;Mammen, 2000;Levi, 2001). In human filoviral cases, fibrin deposition has been documented at autopsy (Gedigk etal, 1968;Murphy, 1978;Geisbert and Jaax, 1998); furthermore, clinical laboratory data suggest that DIC is likely to be a prominent feature of human disease (Egbring et al, 1971;Gear et al, 1975;Isaacson et al, 1978;WHO, 1978a,b). The coagulation picture is clearer for nonhuman primates.…”

Section: Introductionmentioning

confidence: 99%

Filovirus Pathogenesis in Nonhuman Primates

Geisbert¹,

Jahrling²,

Larsen³

et al. 2002

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Clinical Manifestations and Mechanism of the Haemorrhagic Diathesis in Marburg Virus Disease

Cited by 28 publications

References 7 publications

Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions

Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions

Review: Infectious Diseases and Coagulation Disorders

Filovirus Pathogenesis in Nonhuman Primates

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