Clinical manifestations and outcomes of COVID-19 in the paediatric population: a systematic review

Jahangir, Maha; Nawaz, Marrium; Nanjiani, Deedar; Siddiqui, Mishal Shan

doi:10.12809/hkmj208646

Cited by 20 publications

(28 citation statements)

References 30 publications

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“…We included 18 reviews in our analysis. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Characteristics of the included reviews are shown in table 1; all are freely available online (see online supplemental appendix table 2). All reviews were in English.…”

Section: Resultsmentioning

confidence: 99%

“…28 One study provided descriptive data from included studies only and did not report pooled estimates of symptom prevalence. 25 Figure 2 shows the proportions of CYP in each review with reported symptoms or signs of COVID-19 data shown by study in online supplemental appendix table 3. The proportion who were asymptomatic ranged from 14.6% to 42%.…”

Section: Resultsmentioning

confidence: 99%

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Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents

Viner¹,

Ward²,

Hudson³

et al. 2020

Arch Dis Child

171

110

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ObjectiveTo undertake a systematic review of reviews of the prevalence of symptoms and signs of COVID-19 in those aged under 20 years.DesignNarrative systematic review of reviews. PubMed, medRxiv, Europe PMC and COVID-19 Living Evidence Database were searched on 9 October 2020.SettingAll settings, including hospitalised and community settings.PatientsChildren and young people (CYP) under age 20 years with laboratory-proven COVID-19.Study review, data extraction and qualityPotentially eligible articles were reviewed on title and abstract by one reviewer. Quality was assessed using the modified AMSTARS criteria and data were extracted from included studies by two reviewers.Main outcome measuresPrevalence of symptoms and signs of COVID-19.Results1325 studies were identified and 18 reviews were included. Eight were high quality, 7 medium and 3 low quality. All reviews were dominated by studies of hospitalised children. The proportion of asymptomatic CYP ranged from 14.6% to 42%. Fever and cough were the the most common symptoms; proportions with fever ranged from 46% to 64.2% and with cough from 32% to 55.9%. All other symptoms or signs including rhinorrhoea, sore throat, headache, fatigue/myalgia and gastrointestinal symptoms including diarrhoea and vomiting were infrequent, occurring in less than 10%–20%.ConclusionsFever and cough are the most common symptoms in CYP with COVID-19, with other symptoms infrequent. Further research on symptoms in community samples are needed to inform pragmatic identification and testing programmes for CYP.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents

Viner¹,

Ward²,

Hudson³

et al. 2020

Arch Dis Child

171

110

View full text Add to dashboard Cite

show abstract

“…Eight were high quality, 11 14 15 17 19 24 27 28 7 were medium, 16 18 20-23 26 and 3 were low quality. 12 13 25 The very great majority of studies within the reviews were of hospitalised CYP. No reviews specifically focused on symptoms or signs amongst community samples of infected children, and none compared symptoms in hospitalised compared with non-hospitalised children.…”

Section: Resultsmentioning

confidence: 99%

“…28 One study provided descriptive data from included studies only and did not report pooled estimates of symptom prevalence. 25…”

Section: Resultsmentioning

confidence: 99%

Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents

Viner

Hudson

Ashe

et al. 2020

Preprint

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Objective To undertake a systematic review of reviews of the prevalence of symptoms and signs of COVID-19 in those aged under 20 years? Design Narrative systematic review of reviews. PubMed, medRxiv, Europe PMC and COVID-19 Living Evidence Database were searched on 9 October 2020. Setting All settings, including hospitalised and community settings. Patients CYP under age 20 years with laboratory-proven COVID-19. Study review, data extraction and quality Potentially eligible articles were reviewed on title and abstract by one reviewer. Quality was assessed using the modified AMSTARS criteria and data were extracted from included studies by two reviewers. Main outcome measures Prevalence of symptoms and signs of COVID-19 Results 1325 studies were identified and 18 reviews were included. Eight were high quality, 7 medium and 3 low quality. All reviews were dominated by studies of hospitalised children. The proportion who were asymptomatic ranged from 14.6 to 42%. Fever and cough were the commonest symptoms; proportions with fever ranged from 46 to 64.2% and with cough from 32 to 55.9%. All other symptoms or signs including rhinorrhoea, sore throat, headache, fatigue/myalgia and gastrointestinal symptoms including diarrhoea and vomiting are infrequent, occurring in less than 10-20%. Conclusions Fever and cough are the most common symptoms in CYP with COVID-19, with other symptoms infrequent. Further research on symptoms in community samples are needed to inform pragmatic identification and testing programmes for CYP.

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“…The median age in the different series varies between 7 and 11 years. There is no significant difference by sex (21,22). Initially during the pandemic, it was thought that children did not become seriously ill, however more evidence has accumulated showing that children may require intensive care by ∼2 to 6% (22).…”

Section: Covid 19mentioning

confidence: 99%

Emergent Pneumonia in Children

2021

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In recent decades there have been multiple pathogens, viruses and bacteria, which have emerged as causal agents of pneumonia affecting adults, albeit less frequently, to children. For the purposes of this article we have classified emerging pathogens as follows: True emerging, to pathogens identified for the very first time affecting human population (SARS-CoV-1, SARS-CoV-2, MERS-CoV, avian influenza, and hantavirus); Re-emerging, to known pathogens which circulation was controlled once, but they have reappeared (measles, tuberculosis, antimicrobial resistant bacteria such as CA-MRSA, Mycoplasma pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and new serotypes of post-vaccine pneumococcal); and finally, those that we have called old known with new presentations, including common pathogens that, in particular condition, have changed their form of presentation (rhinovirus, and non-SARS coronavirus). We will review for each of them their epidemiology, forms of presentation, therapy, and prognosis in children compared to the adult with the aim of being able to recognize them to establish appropriate therapy, prognostics, and effective control measures.

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Clinical manifestations and outcomes of COVID-19 in the paediatric population: a systematic review

Cited by 20 publications

References 30 publications

Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents

Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents

Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents

Emergent Pneumonia in Children

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