Clinical manifestations associated with human herpesvirus 7 infection.

Torigoe, Sadayoshi; Kumamoto, Takuya; Koide, Waka; Taya, Keiko; Yamanishi, Koichi

doi:10.1136/adc.72.6.518

Cited by 102 publications

(48 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As regards the cases of serologically proven primary HHV-7 infection in Japanese children, in all three children a rising titer of low-avidity antibody to HHV-7 was accompanied by high-titer, high-avidity HHV-6 IgG antibody, and in agreement with others (25,27), it was found that primary HHV-7 infection normally occurs after infection with HHV-6 and is accompanied by a secondary response to HHV-6. Turning to serologically proven primary HHV-6 infection in Japanese children, in all six children we documented seroconversion with low-avidity antibody to HHV-6, but in two children there were significant titers of antibody to HHV-7.…”

Section: Discussionsupporting

confidence: 68%

“…Both viruses belong to the Roseolovirus genus of the betaherpesvirus subfamily of herpesviruses and show very similar biological behaviors: (i) after primary infection they are shed in saliva throughout life (14,16,18,26,33); (ii) primary infection with either virus causes exanthem subitum (roseola infantum) (25,35), a classical exanthematous disease of childhood; and (iii) primary infection with either virus has been associated with childhood neurological illness, particularly febrile convulsions (12,27,28,32), and the DNAs of both HHV-6 (12) and HHV-7 (20) have been detected in cerebrospinal fluid. Any study of the relationship between the two viruses and disease must therefore use diagnostic methods able to distinguish between primary HHV-6 and primary HHV-7 antibody responses.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Use of Immunoglobulin G Antibody Avidity for Differentiation of Primary Human Herpesvirus 6 and 7 Infections

et al. 2001

View full text Add to dashboard Cite

A human herpesvirus 7 (HHV-7) indirect immunofluorescence antibody avidity test was developed and used with an existing human herpesvirus 6 (HHV-6) antibody avidity test to detect and distinguish low-avidity antibodies to HHV-6 and HHV-7 and hence the respective primary infections. With sera from 269 British children aged 0 to 179 weeks, the tests showed that most (10 of 98 serum samples [13%]) HHV-6 low-avidity antibody was found in the first year of life, whereas for HHV-7, most (18 of 101 serum samples [20%]) HHV-7 low-avidity antibody was found in the second year of life. Five children had low-avidity antibodies to both viruses. Of nine Japanese children with previously serologically proven primary HHV-6 or HHV-7 infections, eight had low-avidity antibody only to the relevant virus, but one child had low-avidity antibodies to HHV-6 and HHV-7. The avidity tests were applied to five British children and further proof of viral infection was sought by the detection of specific DNA in serum or plasma, and saliva or cerebrospinal fluid. In two children who had low-avidity antibody to HHV-7 but who were seronegative for HHV-6, only HHV-7 was found. Both viruses were detected in one child with low-avidity HHV-7 antibody and high-avidity HHV-6 antibody. In two children with low-avidity antibodies to both viruses, HHV-6 and HHV-7 DNAs were found, confirming dual primary infections and excluding antibody cross-reactivity.

show abstract

Section: Discussionsupporting

confidence: 68%

mentioning

confidence: 99%

Use of Immunoglobulin G Antibody Avidity for Differentiation of Primary Human Herpesvirus 6 and 7 Infections

et al. 2001

View full text Add to dashboard Cite

show abstract

“…17,21 It is not known whether HHV-7 invades the central nervous system, although reports of complications linked to primary HHV-7 infection are increasing. 13,25 As reported elsewhere, 9 -11,13 at least 53% of the 15 showed a significant simultaneous rise in antibody titers to HHV-6 during primary HHV-7 infection. This phenomenon will be explained by antigenic cross-reactivities 2,8,22 between both viruses or by reactivation of HHV-6 in a latent form by HHV-7.…”

Section: Discussionmentioning

confidence: 84%

“…The frequency was 28% among 50 with febrile exanthem, comparable with the frequency reported recently by others, ie, 37% 10 and 31%. 13 A larger prospective cohort study will be required to know the precise frequency of primary HHV-7 infection in patients with febrile exanthem and that of febrile exanthem among primary HHV-7 infection in childhood. As suggested elsewhere, 7,9 -13,20 the present data also indicate that primary infection with HHV-7 occurs after development of ES, the primary infection with HHV-6, because 54% had a clinical history of ES and 87% had HHV-6 antibody at the acute stage of HHV-7 infection.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Virological Findings in Children With Primary Human Herpesvirus 7 Infection

Suga

Yoshikawa

Nagai³

et al. 1997

Pediatrics

View full text Add to dashboard Cite

ABSTRACT. Objective. To elucidate clinical features of patients with primary human herpesvirus 7 (HHV-7) infection and serologic and virologic findings between HHV-7 and human herpesvirus 6 (HHV-6).Materials and Methods. During a 19-month observation period, 71 infants and children (35 boys and 36 girls with a mean age of 14.5 months [range, 1 month to 48 months]) who had acute febrile respiratory illness with or without skin rash were examined clinically and virologically. Heparinized blood samples were used for isolation of HHV-6 and HHV-7 and detection of both virus DNA sequences by a nested polymerase chain reaction amplification. Both virus antibody activities were measured by an indirect immunofluorescent assay.Results. HHV-7 infection was observed in 15 (6 boys and 9 girls with a mean age of 12.9 months [range, 7 months to 27 months]), 1 of 10 with upper respiratory infection and 14 (28%) of 50 with febrile exanthem, whereas HHV-6 infection was in 22 (44%) of the 50. Fever (37.5°C) was observed in all 15, with an average maximum body temperature of 38.7°C (range, 37.6°C to 39.8°C), which persisted for 2.9 days (range, 1 to 5 days). Papular, macular, or maculopapular rash was observed in 14 (93%) of the 15, which appeared on day 2.9 of fever (range, days 2 to 5) on the face, trunk, and extremities and persisted for 2.7 days (range, 1 to 5 days). A convulsive seizure that persisted for a few minutes developed in 1 patient on the first day of elevation of fever. HHV-6 antibody was demonstrated in 13 (87%), and a simultaneous significant increase to HHV-6 antibody titers was observed in 8 (53%) of the 15 during primary HHV-7 infection. HHV-7 and HHV-6 DNAs were almost always detected in mononuclear cells (MNCs) during acute and convalescent phases, whereas HHV-7 DNA was positive in some plasma samples obtained during the acute phase of the disease.Conclusions. Primary HHV-7 infection occurred somewhat later than HHV-6, which was confirmed by the isolation of HHV-7 from blood and/or seroconversion to the virus. Clinical features of a virologically confirmed patient with primary HHV-7 infection were comparable with those of primary HHV-6 infection. Preexisting HHV-6 antibody increased significantly in the half of patients with primary HHV-7 infection. HHV-7 DNA was detected in peripheral blood MNCs and plasma in the acute phase and persisted in MNCs thereafter. Pediatrics 1997;99(3). URL: http://www.pediatrics.org/cgi/ content/full/99/3/e4; human herpesvirus 7, human herpesvirus 6, exanthem subitum, roseola infantum, polymerase chain reaction.

show abstract

“…Cross-reactivity between HHV-6 and HHV-7 antibodies has been demonstrated (6,19,20,24), and an interaction between these viruses in vitro has been postulated (13). Although an indirect immunofluorescence assay (IFA) is commonly used to determine titers of antibody against these viruses, the inability of this assay to distinguish cross-reacting HHV-6 and HHV-7 antibodies is problematic.…”

mentioning

confidence: 99%

Comparison of Specific Serological Assays for Diagnosing Human Herpesvirus 6 Infection after Liver Transplantation

Yoshikawa

Black

Ihira

et al. 2001

Clin Diagn Lab Immunol

View full text Add to dashboard Cite

Cross-reactivity between human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) antibodies and the reliability of specific serological assays were analyzed for 12 patients with concurrent HHV-6 and HHV-7 antibody responses after transplantation with a liver from a living relative by using an immunofluorescence assay (IFA). A neutralizing antibody titer assay (NT) and an immunoblot assay (IB) designed to detect immunoglobulin M (IgM) antibody to the HHV-6 immunodominant 101-kDa protein were compared in the diagnosis of an active HHV-6 infection. A total of 9 of 12 patients demonstrated concurrent HHV-6 and HHV-7 antibody responses, including increased IgG titers and/or the presence of IgM by IFA, and were thus analyzed for cross-reactive antibody to heterologous virus. The average percentages of residual antibody to HHV-6 and HHV-7 after absorption with HHV-6 antigen were 32.6% (range, 6 to 50%) and 55.6% (range, 35 to 100%), respectively. All 12 patients were subsequently analyzed for HHV-6 antibody by using IB and NT. IB detected IgM antibody to the 101-kDa protein in 75% (9 of 12) of the recipients. A significant rise in the NT antibody titer was detected in the same nine samples. However, HHV-6 DNA was detected by PCR in only five of nine plasma samples collected from recipients with a specific serologic response against HHV-6.

show abstract

Clinical manifestations associated with human herpesvirus 7 infection.

Abstract: Human herpesvirus 7 (HHV-7) is a new herpesvirus recently isolated from CD4+ T cells. I Recently, we reported that HHV-7 was a causal agent for exanthem subitum.2 In this report, we examined the clinical manifestations associated with HHV-7, especially exanthem subitum.

Cited by 102 publications

References 5 publications

Use of Immunoglobulin G Antibody Avidity for Differentiation of Primary Human Herpesvirus 6 and 7 Infections

Use of Immunoglobulin G Antibody Avidity for Differentiation of Primary Human Herpesvirus 6 and 7 Infections

Clinical Features and Virological Findings in Children With Primary Human Herpesvirus 7 Infection

Comparison of Specific Serological Assays for Diagnosing Human Herpesvirus 6 Infection after Liver Transplantation

Contact Info

Product

Resources

About