Clinical manifestations, hormonal profile and rationale of the polycystic ovary syndrome and infertility in Pakistani women

Abstract

Introduction: Many women of reproductive age experience polycystic ovary syndrome (PCOS), characterized by growth of cysts on the ovaries that range in size from 2 to 10mm in antral measurement, oligomenorrhea, menorrhagia, acne and hyperandrogenism. Objective: The study aimed to correlate the rational of PCOS with infertility in women. Place and Duration: The study was conducted in different districts of Sindh in Pakistan during the period 2020-22. Methods: This cross-sectional study aimed to determine how common infertility was among women with PCOS who sought care at different gynecological clinics. Pathological investigation of the patient's hormonal profile, including serum insulin, serum prolactin, LH, FSH, and serum testosterone levels were also investigated. Results: 316 of infertile women (63.20%) were diagnosed with PCOS. Females had oligomenorrhea as the predominant (p<0.05) pattern of the PCOS-affected females. Acne, hirsutism, and hyperandrogenism were significantly (P<0.05) more common among these women. In women with PCOS, the level of testosterone was significantly elevated (132+2.39 ng/dl; P<0.05). Conclusion: PCOS is the leading cause of infertility owing to anovulation, as affected women displayed severe clinical manifestations of oligomenorrhea, hirsutism, acne, hyperandrogenism, and elevated testosterone levels and thus can easily be diagnosed and treated accordingly.