Clinical Manifestations of High and Low Plasma Magnesium

Hirschfelder, Arthur D.; Haury, Victor G.

doi:10.1001/jama.1934.02750140024010

Cited by 135 publications

(28 citation statements)

References 8 publications

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“…The fact that only about 1 per cent of an intravenous load of Mg25 appeared in the stools is strongly against the possibility that magnesium is absorbed from the gut at one point and re-excreted into it at another. The marked disparity between these data and some of those derived from nonisotopic studies (19) indicates the need for further study with the isotope, possibly using several other salts of Mg++.…”

Section: "Exchangeable" Mg++mentioning

confidence: 91%

MAGNESIUM TURNOVER IN THE HUMAN STUDIED WITH Mg28*

Silver¹,

Robertson²,

Dahl³

et al. 1960

J. Clin. Invest.

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Despite the relatively large amounts of magnesium present in the cells of most mammals, its in vivo functions in man remain poorly defined, a point which is emphasized in a recent review by Wacker and Vallee (1). There is evidence, which is still equivocal, that abnormalities of magnesium metabolism may be involved in several disease states including atherosclerosis (2), myxedema (3), hyperthyroidism (4), acute alcoholism (5), and possibly other conditions (6). Although Wacker and Vallee emphasized that, in view of its established capacity to function as an activator for many in vitro enzyme systems magnesium must play a significant role in intracellular metabolic activity, one of the intriguing aspects of magnesium has been its apparently relative inertness-particularly striking when compared with the other major ions in the body. Study of magnesium has been aided by the advent of the isotope Mg28 (7), although some caution has been necessary in using this isotope as well as in interpreting results obtained with it because of the relatively low specific activity which has been attained. With these limitations in mind we have made studies that tend to confirm earlier data arrived at by nonisotopic techniques, namely, that there are several relatively small, rapidly equilibrating compartments and one or more in which turnover is very slow. These data on man suggest that there are at least three compartments in the body pool of magnesium turning over with half-times of 1, 3, and 14 to 35 hours, respectively, but that probably 25 to 50 per cent of the magnesium has a turnover rate of less than 2 per cent per day. MATERIALS AND METHODSClinical data. The 10 white adults-3 males of 45, 55 and 62 years of age, and 7 females aged 38, 46, 52, 53, 55, 64 and 72 years-were studied on the metabolic wards of the Hospital of the Brookhaven Medical Research * This investigation was supported by the United States Atomic Energy Commission.Center for several months or more during the period of these investigations. All but the male aged 55 suffered from hypertension. Since the present observations are not clearly relevant to hypertension, only clinical data which might be pertinent to the present study are mentioned. The male of 55 had had classical rheumatoid arthritis of 3 years' duration but no other disease. The male of 62, who had a history of syphilis, was found to have positive serological tests for syphilis; the root of the ascending aorta was somewhat dilated by X-ray and a

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Section: "Exchangeable" Mg++mentioning

confidence: 91%

MAGNESIUM TURNOVER IN THE HUMAN STUDIED WITH Mg28*

Silver¹,

Robertson²,

Dahl³

et al. 1960

J. Clin. Invest.

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“…Subsequently (309). These findings were trans-lated to humans, and the first report of Mg 2ϩ deficiency in humans was by Arthur Hirschfelder and Victor Haury in 1934 (231). Since then, Mg 2ϩ has been implicated in and used for treatment of a variety of diseases, including migraines, cardiovascular diseases, and diabetes.…”

mentioning

confidence: 92%

Magnesium in Man: Implications for Health and Disease

Baaij

Hoenderop

Bindels

2015

Physiological Reviews

1,285

1,299

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“…There are conflicting reports in literature concerning serum magnesium in chrome renal diseases. Hirschfelder and Haury (1934), Martin et al (1952) found (1) hypomagnesaemia while Pradhan el al (1964) (2) and numerous others workers found definite hypermagnesaemia in chronic renal disease. Pathophysiology of certain symptoms in uraemia remains a mystery.…”

Section: Introductionmentioning

confidence: 97%

Study of Serum Magnesium Level in Acute Kidney Injury and Chronic Kidney Disease and Its Clinical Manifestations and Correlation With Other Biochemical Parameters

Naik¹,

Jagat²,

Dhurvey³

et al. 2015

jemds

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OBJECTIVES: To study the serum magnesium level in AKI and CKD, and its correlation with clinical manifestations and other biochemical parameters. DESIGN: A hospital-based cross sectional study. SETTING: Tertiary care teaching hospital in central India. SUBJECTS: Study population comprised of 75 cases of renal failure (50 CKD and 25 AKI) and 25 healthy control cases. METHODS: Studs populations included were subjected to a thorough history taking with special emphasis to exclude the presence of other diseases which are known to alter the magnesium levels in serum. Diagnosis of renal-failure was established by measuring raised clinical blood urea nitrogen and serum creatinine with clinical sign and symptoms of renal failure. Serum magnesium level is measured in "mg/dl" using metallochromic dye (Xylidyl) colorimetric assay. Relevant predefined clinical and biochemical parameters recorded from each subjects in all three groups. Data were computed and analyzed using SPSS statistical software. RESULTS: Hundred subjects were enrolled in the study, 75 cases of renal failure (50 CKD and 25 AKI) and 25 healthy control cases. Range of serum magnesium in controls was 1.32 to 2.4mg/dl with a mean 1.856(±0.2959). Mean blood urea, serum creatinine, sodium, potassium, calcium and magnesium level were 127.65 mg/dl, 6.75mg/dl, 135.24 MEq/L, 4.86 MEWL, 9.28mg/dl and 2.89mg/dl respectively in AKI cases, and 111.36mg/dl, 7.02 m2/d1, 135.01 MEq/L, 4.93 MEq/L, 8.99mg/dl and 2.75mg/dl respectively in CKD cases. Eight (16%) CKD cases had central nervous system depression with their mean serum magnesium level of 3.61 mg/dl. Four (16%) AKI cases had central nervous system depression with mean serum magnesium level of 3.47mg/dl. CONCLUSION: Serum magnesium level has prognostic significance in severity in AKI and CKD and CNS symptoms. Baseline serum magnesium should be done in every case of CKD and AKI with other electrolytes and renal function tests. There is positive correlation between serum magnesium and blood urea, creatinine & potassium while negative correlation between serum magnesium and serum sodium & calcium levels both in AKI and CKD case.

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Clinical Manifestations of High and Low Plasma Magnesium

Cited by 135 publications

References 8 publications

MAGNESIUM TURNOVER IN THE HUMAN STUDIED WITH Mg28*

MAGNESIUM TURNOVER IN THE HUMAN STUDIED WITH Mg28*

Magnesium in Man: Implications for Health and Disease

Study of Serum Magnesium Level in Acute Kidney Injury and Chronic Kidney Disease and Its Clinical Manifestations and Correlation With Other Biochemical Parameters

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