Clinical Manifestations of Neoplasia of the Heart

Kapoor, Amar S.

doi:10.1007/978-1-4612-4898-9_2

Cited by 12 publications

(10 citation statements)

References 19 publications

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“…Eighty four percent of heart tumors are benign and rarely malignant [Grande et al, 1993]. Majority of the myocardial tumors are myxomas, ®broelastomas and ®brosarcoma [Kapoor, 1986]. The histological analysis of heart tumors suggest the presence of endothelial cells, macrophages, mature or immature smooth muscle cells, ®broblasts, and elastic ®bers covered by an abundant acid mucopolysaccharide matrix [Kapoor, 1986].…”

Section: Discussionmentioning

confidence: 99%

“…Majority of the myocardial tumors are myxomas, ®broelastomas and ®brosarcoma [Kapoor, 1986]. The histological analysis of heart tumors suggest the presence of endothelial cells, macrophages, mature or immature smooth muscle cells, ®broblasts, and elastic ®bers covered by an abundant acid mucopolysaccharide matrix [Kapoor, 1986]. Extracts from tissues, such as cartilage is one of the few avascular tissues which can inhibit angiogenesis and growth of tumor cell.…”

Section: Discussionmentioning

confidence: 99%

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Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts

2001

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Tumor cells become malignant, in part, because of their activation of matrix metalloproteinases (MMPs) and inactivation of tissue inhibitor of metalloproteinases (TIMPs). Myocardial tumors are rarely malignant. This raises the possibility that the MMPs and TIMPs are differentially regulated in the heart compared to other tissues. Therefore, we hypothesized that a tissue specific tumor suppressor exists in the heart. To test this hypothesis we prepared cardiac tissue extracts from normal (n = 4), ischemic cardiomypathic (ICM) [n = 5], and dilated cardiomyopathic (DCM) [n = 8] human heart end-stage explants. The level of cardiospecific TIMP-4 was determined by SDS-PAGE and Western-blot analysis. The results suggested reduced levels of TIMP-4 in ICM and DCM as compared to normal heart. TIMP-4 was purified by reverse phase HPLC and gelatin-sepharose affinity chromatography. Collagenase inhibitory activity of chromatographic peaks was determined using fluorescein-conjugated collagen as substrate and fluorescence spectroscopy. The activity of TIMP-4 (27 kDa) was characterized by reverse zymography. The role of TIMP-4 in cardiac fibroblast cell migration was examined using Boyden chamber analysis. The results suggested that TIMP-4 inhibited cardiac fibroblast cells migration and collagen gel invasion. To test whether TIMP-4 induces apoptosis, we cultured cardiac normal and polyomavirus transformed fibroblast cells in the presence and absence of TIMP-4. The number of cells were measured and DNA laddering was determined. The results suggested that TIMP-4 controlled normal cardiac fibroblast transformation and induced apoptosis in transformed cells. Cardiospecific TIMP-4 plays a significant role in regulating the normal cell phenotype. The reduced levels of TIMP-4 elicit cellular transformation and may lead to adverse extracellular matrix degradation (remodeling), cardiac hypertrophy and failure. This study suggests a possible protective role of TIMP-4 in other organs which are susceptible to malignancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts

2001

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“…The incidence of metastatic malignancies to the myocardium and the pericardium has been described from less than 1%to more than 20%of all cancer patients and this incidence varies with the type of malignancy (1)(2)(3)(4). The managementof pericardial effusion in patients with malignancy is an important problem that confronts both the oncologist and the cardiologist.…”

Section: Introductionmentioning

confidence: 99%

Percutaneous Balloon Pericardiotomy by the Use of Inoue Balloon for the Management of Recurrent Cardiac Tamponade in a Patient with Lung Cancer.

et al. 2000

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A 32-year-old man with lung cancer involving pericarditis carcinomatosa underwent pericardiotomy, using an Inoue balloon dilating catheter, to create a non-surgical pericardial window. The procedure was performed from the thoracic wall to the left pleural effusion and parietal pericardium under local anesthesia. The effects of non-surgical pericardial window had been maintained until this patient died from his primary disease. It is concluded that percutaneous balloon pericardiotomy is helpful in the management of massive pericardial effusions particularly in patients with malignancies and poor clinical condition.

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“…With rega rd to general, constitutional symptoms, gener a lized weakness , weight loss, malaise, easy fatigability, and dyspn ea are symptoms that a re common to man y disease states an d do not give a clue to which organ syste m is involved . These constitutiona l symptoms may be due to a) the und er lying malignant disease; b) ass ociated ca rdiovas-cular decompensat ion secondar y to chemothera py; 3) pulmonary involvement from chro nic lung disease (10). The most common cardiovasc ular sym ptoms of cardiac tumors ar e dyspn ea, syncope, chest pain, palpitations, and congestive heart failure .…”

Section: A Clinical Man Ifes Tations Of Car Diac Tumorsmentioning

confidence: 99%

Clinical Aspects of Cardiac Tumors

Tillmanns

1990

Thorac cardiovasc Surg

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Due to surgical advances, cardiac tumors now represent a potentially curable form of heart disease. Primary cardiac tumors are very rare; secondary, metastatic tumors are 10-40 times more frequent. The majority (75%) of primary tumors is benign. Cardiac tumors may produce hemodynamic disturbances, mechanical hemolysis, biochemical effects and constitutional symptoms. According to the anatomic location of the tumor, some special symptoms and physical findings can be grouped with regard to pericardial, myocardial, and endocardial involvement. Several laboratory data (elevated sedimentation rate, anemia, thrombocytopenia etc.) may give additional hints to suggest cardiac involvement in neoplastic disease. Among the diagnostic procedures, two-dimensional echocardiography has become the most important method for non-invasive detection of cardiac tumors. The importance of invasive procedures has declined by the improvement of non-invasive imaging techniques, but pressure measurements within the cardiopulmonary system, left-sided, pulmonary angiography as well as coronary angiography give additional useful and necessary information prior to surgery. Within the spectrum of differential diagnosis, particularly mitral, aortic, or tricupid valve disease, bacterial endocarditis, or autoimmune diseases have to be ruled out. Thus, in the vast majority of cases the correct diagnosis can be made. This is crucial for further management of the patient since the majority of primary cardiac tumors can be successfully treated by surgery.

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Clinical Manifestations of Neoplasia of the Heart

Cited by 12 publications

References 19 publications

Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts

Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts

Percutaneous Balloon Pericardiotomy by the Use of Inoue Balloon for the Management of Recurrent Cardiac Tamponade in a Patient with Lung Cancer.

Clinical Aspects of Cardiac Tumors

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