Clinical Manifestations of Papillary Muscle Dysfunction

Mitral valve prolapse in short-term experimental coronary occlusion: a possible mechanism of ischemic mitral regurgitation.

“…THE CLINICAL MANIFESTATIONS of papillary muscle dysfunction were first described by Burch et al' in 1963. They proposed two major pathophysiologic mechanisms by which ischemic dysfunction may lead to mitral regurgitation and speculated that failure of an ischemic or fibrotic papillary muscle to shorten during ventricular contraction would cause mitral valve leaflet prolapse.…”

The Role of Cardiac MRI In Coronary Heart Disease Management

“…Signs of elevated pulmonary venous pressure are found in some patients with IHD. Chronic left ventricular ischemia may result in ventricular dilatation and mitral incompetence, causing left atrial and ventricular dilatation (16,17) . In acute myocardial infarction, the most common radiographic abnormalities in these patients result from dramatic increases in left atrial pressure (18) , acute myocardial infarction may result in pulmonary edema, present as diffuse, bilateral, fluffy pulmonary infiltrates.…”

“…10 to 20 minutes after intravenous injection of 0.1 to 0.2mmol/kg of gadolinium chelate, Imaging can typically be performed (1) . the microvascular obstruction could be detected by CMR (15,16) it can be seen that the extent of microvascular obstruction and infarct size increases substantially over the first 48 hours after an MI (15) .…”

Mechanisms and Clinical Implications of Asymptomatic Mitral Regurgitation in Patients With Left Ventricular Dysfunction

“…[13][14][15][16] Also, recent studies have suggested that remodeling of the LV is one of the main mechanisms of functional MR. 17,18 Here, we investigated LV deformation and studied how it relates to functional MR during exercise in patients with chronic heart failure (CHF).…”