Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder

Gong, Yan; Xiong, Kang-Ping; Mao, Cheng‐Jie; Shen, Yun; Hu, Weidong; Huang, Junying; Han, Fei; Chen, Rui; Liu, Chunfeng

doi:10.1016/j.sleep.2013.12.021

Cited by 65 publications

(40 citation statements)

References 29 publications

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“…Another 1,187 studies were excluded because they were reviews (n = 655), case reports (n = 166), animal studies (n = 306) or editorials (n = 50). Ultimately, 31 articles1278202122232425262728293031323334353637383940414243444546 were included in our analysis (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis

Zhu

Xie

et al. 2017

Sci Rep

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This study aimed to evaluate the clinical variations in patients with Parkinson’s disease (PD) with (PDRBD) or without REM sleep behaviour disorder (RBD) (Non-RBD), and PDRBD patients were classified into Confirmed-RBD (definite diagnosis with polysomnography, PSG) and Probable-RBD (without PSG re-confirmation). The clinical difference between the groups of patients was measured as an odds ratio (OR) or standardized mean difference (SMD, Cohen d). A total of 31 articles with data from 5,785 participants were obtained for our analysis. Overall, the occurrence of Confirmed-RBD was more frequent in male patients (OR = 1.25; p = 0.038), elderly patients (SMD = 0.25; p = 0.000), and patients with longer disease duration (SMD = 0.30; p = 0.000), increased Hoehn-Yahr scale (SMD = 0.30; p = 0.000), and higher UPDRS-III score (SMD = 0.38; p = 0.002). On the other hand, the frequency of Probable-RBD was increased with disease duration (SMD = 0.29; p = 0.000), Hoehn-Yahr scale (SMD = 0.30; p = 0.000), and UPDRS-III score (SMD = 0.26; p = 0.001). Our study indicate that PDRBD patients may have different clinical features compared to patients with Non-RBD.

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Section: Resultsmentioning

confidence: 99%

Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis

Zhu

Xie

et al. 2017

Sci Rep

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“…In studies of pRBD in PD, RBD preceding PD was associated with younger age of PD onset and more severe disease manifestations[16]. Shorter duration between RBD symptom onset and development of motor manifestations has also been associated with greater risk of cognitive impairment[17]; possibly indicating greater neurodegeneration in these cases[17]. RBD persists in some patients throughout the course of their disease but resolves in others; in one study, approximately 30% of PD patients had resolution of pRBD within 4 years[18].…”

Section: Rem Sleep Behavior Disordermentioning

confidence: 99%

“…In regards to RBD in already-manifest PD, QOL is reduced in PD patients with RBD compared to those without[17,97]. Whether this results from the RBD itself and/or the co-morbid signs and symptoms (table 2) requires further study.…”

Section: Rem Sleep Behavior Disordermentioning

confidence: 99%

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A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Chahine

Amara

Videnović

2017

Sleep Medicine Reviews

273

249

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Sleep disorders are among the most common non-motor manifestations in Parkinson’s disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005-2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated features, evaluation measures, and management of these disorders. The influence on sleep of medications used in the treatment of motor and non-motor symptoms of PD is detailed. Additionally, we suggest areas in need of further research.

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“…Circadian rhythm or wake-promoting system, is one of the central factors controling the physiology and behaviors of PD patients [50]. In PD patients, nonmotor symptoms such as insomnia, excessive morning sleepiness, rapid-eye-movement sleep behavior disorder and obstructive sleep apnea are very frequently reported upon examination [11,13]. Depression in fact is associated with a disturbed circadian rhythm [51][52].…”

Section: Melatonin Regulates Circadian Rhythm In Pdmentioning

confidence: 99%

The Roles of Melatonin in Parkinson’s Disease: An Overview

Moi¹,

Lim²,

Koh³

et al. 2017

SDRP-JCMP

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When the central nervous system loses its nerve cell functions over a period of time, symptoms and problems arise leading to the progression of neurodegenerative diseases. Statistical data shows that more than 5 million people worldwide are affected by Parkinson's disease [PD], and the data is undesirably rising every year. In PD patients, structural and functional changes are shown in the brain, especially the substantia nigra region. The underlying cause that correspond to the development of PD remains unclear. Nevertheless, α-synuclein aggregation has been reported to be neuropathologically linked to PD. On the other hand, several evidences successfully demonstrate the importance and significance of mitochondrial dysfunction in PD models. Treatments available for PD are limited. Recently, as shown in some studies, the antioxidant properties and hypnotic benefits of melatonin bring remarkable contribution to the PD patients. Hence, in this article, we focus on the effect of melatonin associating with the pathology and physiology of PD.

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Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder

Cited by 65 publications

References 29 publications

Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis

Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

The Roles of Melatonin in Parkinson’s Disease: An Overview

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