Clinical Manifestations of Senecavirus A Infection in Neonatal Pigs, Brazil, 2015

Abstract

We identified new clinical manifestations associated with Senecavirus A infection in neonatal piglets in Brazil in 2015. Immunohistochemical and molecular findings confirmed the association of Senecavirus A with these unusual clinical signs and more deaths. Other possible disease agents investigated were not associated with these illnesses.

The First Identification and Complete Genome of Senecavirus A Affecting Pig with Idiopathic Vesicular Disease in China

“…In Brazil, acute death of neonatal piglets was observed; however, no gross or histopathological lesions were seen in the necropsied piglets (Vannucci et al., ). Petechial haemorrhages of kidney and interstitial pneumonia were observed in piglets in our study, which were the same as the clinical manifestations described in the Brazilian study (Leme et al., ). According to our histopathological results, there was suppurative inflammation in dermis and epidermis, cell necrosis and damage of epithelial cells in hoof, which might be related to the suppurative lesions in the feet of piglets.…”

“…Three reports described detection and genomic characterization of SVA in the United State in 2015 (Guo et al., ; Hause et al., ; Wang et al., ). The Brazilian study evaluated the SVA infection in neonatal piglets and suggested that urine might be a possible route for the dissemination of this virus (Leme et al., ). Clinical signs and gross lesions were observed in nursery‐age pigs which received an intranasal inoculation of SVA isolate, demonstrating a causative relationship between SVA infection and vesicular disease (Montiel et al., ).…”

Emergence of novel Seneca Valley virus strains in China, 2017

“…SVV was originally isolated from cell culture media and identified as a cell culture contaminant in the United States (US) in 2002 (Hales et al., ). SVV infection has been reported in the US, Canada, Brazil and China in recent years that was associated with porcine idiopathic vesicular disease (PIVD) in pigs and increased neonatal mortality in piglets ≤7 days of age (Hause, Myers, Duff, & Hesse, ; Leme et al., ; Pasma, Davidson, & Shaw, ; Zhao et al., ).…”

A new wave of Seneca Valley virus outbreaks in Brazil

“…Vesicular lesions were more commonly reported from finishing pigs and breeders, especially in sows, with approximately 30% of morbidity rates (Leme et al., ; Vannucci et al., ). Simultaneously, newborn piglets were also affected by SVV infection, with consequent morbidity and mortality rates considerably higher (Leme, Oliveira, Alfieri, Headley, & Alfieri, ; Leme et al., However, the clinical manifestations in older pigs and high mortality rates in piglets last for approximately 2–3 weeks in the affected herd.…”