Clinical Manifestations of Syphilitic Uveitis in the Korean Population

Kwak, Hyun Duck; Kim, Hyun Woong; Lee, Ji Eun; Lee, Joo Eun; Lee, Sang Jun; Yun, Il Han

doi:10.3341/jkos.2014.55.4.555

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…(Browning 2000;Fonollosa et al 2009;Lee et al 2015). A much lower incidence (up to 8%) has been reported from Asia (Hong et al 2007;Kwak et al 2014;Shen et al 2015). In our study, the coinfection rate of ocular syphilitic disease and HIV was 39%, similar to that described in the BOSS Study (Mathew et al 2014) and the recent Australian (Northey et al 2015) and Spanish (Fonollosa et al 2016) reports in which the co-infection rate was 31.7%, 32% and 34%, respectively.…”

Section: Discussionmentioning

confidence: 98%

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis

Klein

Fischer

Goldstein

et al. 2018

Acta Ophthalmologica

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Purpose Ocular manifestations of syphilis have been reported in 2–10% of systemic infection. The purpose of this study was to report the incidence of ocular syphilis and various ocular manifestations, particularly optic nerve involvement, in newly diagnosed cases. Methods This was a retrospective study. Medical records of newly diagnosed syphilis patients between January 2009 and January 2017 in a tertiary medical centre were reviewed. Results There were 123 new systemic syphilis cases out of 569,222 (0.02%) admissions to the Tel Aviv Medical Center during the study period. Ninety‐three of the 123 patients (76%) underwent ophthalmological examination. Twenty‐three of the 93 patients (25%, mean age 48.6 ± 12.9 years, 20 males) had ocular syphilis, and in 12/23 (52%) patients, the ocular symptoms and findings prompted syphilis investigation. Eighteen of the 23 (78%) had optic nerve involvement, and the most common was inflammatory disc oedema. Older age (p = 0.0005) and tertiary stage disease (p = 0.0441) were associated with ocular manifestations and the presence of optic nerve findings. Human immunodeficiency virus (HIV) was associated with ocular but not optic nerve findings. Treatment included intravenous penicillin G, and four patients with severe optic neuropathy were also treated with systemic corticosteroids. Visual acuity significantly improved in most patients (p < 0.05). Conclusion Ocular syphilis was found in one‐quarter of the patients diagnosed with systemic syphilis and preceded the diagnosis of systemic disease in one‐half of them. Optic nerve involvement was a common manifestation. A high index of suspicion for Treponema infection is required in patients presenting with optic nerve involvement to facilitate prompt diagnosis and treatment. Post‐treatment visual outcome was good.

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Section: Discussionmentioning

confidence: 98%

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis

Klein

Fischer

Goldstein

et al. 2018

Acta Ophthalmologica

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“…The majority of the rate increase can be attributed to men who practice unsafe sexual behaviors and have a higher prevalence of co-infection with HIV. Despite the approximately six-fold increase in HIV infection in Korea over the last decade, a recent report by Kwak et al [ 22 ] revealed that HIV-related ocular syphilis was not common in a Korean population. This result was also supported by a study by Anshu et al [ 23 ], who reported 22 Singapore patients with syphilitic uveitis and a negative HIV serology.…”

Section: Discussionmentioning

confidence: 99%

Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes

Kim

Kwak

2016

Korean J Ophthalmol

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PurposeTo describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus (HIV) infection.MethodsA total of 45 eyes from 39 patients with ocular syphilis confirmed by serologic tests were reviewed retrospectively. The included cases were all non-HIV-infected patients presenting with intraocular inflammation from 2002 to 2014 at Kyung Hee University Hospital. Medical records of 45 eyes were analyzed and included best-corrected visual acuity and ophthalmologic examination findings of the anterior and posterior segments to determine the focus of inflammation. Optical coherence tomography and fluorescein angiography findings as well as both medical and surgical management were also analyzed.ResultsThe mean patient age was 61.0 years (range, 37 to 89 years). Bilateral ocular involvement occurred in 6 patients (15.4%), and diagnoses at presentation were most frequently related to posterior uveitis (38%), followed by panuveitis (29%) and optic neuritis (11%). Isolated interstitial keratitis and intermediate uveitis were uncommon (4%, both). Twenty-eight eyes (62.2%) were treated with penicillin, and 11 eyes (24.4%) underwent surgical treatment. The mean baseline best corrected visual acuity was 0.79 ± 0.59 (mean ± standard deviation, logarithm of the minimum angle of resolution) and significantly improved to 0.60 ± 0.63 at the final follow-up after treatment (p = 0.019). Mean visual improvement was significantly greater in the penicillin-treated group (p = 0.001). Visual impairment at the final visit occurred in 11 eyes (24.4%). Among the visual impairment group, 10 eyes (90.1%) had posterior segment-involving uveitis.ConclusionsVisual outcomes of treated, non-HIV-related ocular syphilis were favorable regardless of time to presentation. Posterior segment-involving uveitis at presentation was associated with poor visual outcome.

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“…However, in our group, reactive halide flux technique has been used to prepare many new metal chalcogenides and chalcogenophosphates. This synthetic route has proved to be of general utility in preparing new multinary chalcogenides . In an attempt to search for new phases in the Ag–Nb–V–S system using eutectic halide fluxes, we have found a new one‐dimensional niobium sulfide chloride.…”

Section: Selected Interatomic Distances (å) For Nb24s95cl7mentioning

confidence: 99%

Synthesis and Crystal Structure of the New One‐Dimensional Ternary Niobium Sulfide Chloride, Nb₂₄S₉₅Cl₇

Yoon

Kwak

Lee

et al. 2017

Bulletin Korean Chem Soc

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Most of the group 5 metal chalcogen-rich ternary M/Q/X system (M = Nb, Ta; Q = S, Se; X = Cl, Br) have been reported to have low-dimensional structures and interesting properties induced by the low-dimensional nature. 1-5 The structures of these compounds are usually composed of one-dimensional chains in which the metal atoms are arranged in waved distributions with sequences of short and long intermetallic distances. The metal atoms are connected through disulfides (S 2 2− ) and sulfide anions and various metal-centered polyhedra play roles as basic structural building blocks. The intermetallic distances vary and diversified structures can be obtained from the various combinations of metals and bridging anions. Most of the compounds in this family have been prepared from the mixtures of elements. However, in our group, reactive halide flux technique has been used to prepare many new metal chalcogenides and chalcogenophosphates. This synthetic route has proved to be of general utility in preparing new multinary chalcogenides. [5][6][7][8][9][10][11] In an attempt to search for new phases in the Ag-Nb-V-S system using eutectic halide fluxes, we have found a new one-dimensional niobium sulfide chloride. Here we report the synthesis and structural studies of Nb 24 S 95 Cl 7 .The structure of Nb 24 S 95 Cl 7 is composed of three crystallographically independent one-dimensional chains extended along the [110] direction. (Figure 1) The chains have similar shapes and all of them are comprised of alternating clusters made from three and five Nb atoms. The three-and five-membered linear clusters are constructed from two and four consecutive short intermetallic bonds (Nb-Nb: 2.9220 (6)~3.1394(6) Å, Table 1), respectively. Each cluster is connected by bridging S atoms to form one-dimensional chains. (Figure 2) The coordination around the terminal Nb atoms of the clusters is responsible for the different structure of the chains. In the type I chain, 1 ∞ [Nb 8 S 32 Cl 2 ], only the terminal Nb atoms (Nb(1), Nb(3)) of the threemembered cluster have Cl ions and the type II chain,

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Clinical Manifestations of Syphilitic Uveitis in the Korean Population

Cited by 6 publications

References 23 publications

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis

Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes

Synthesis and Crystal Structure of the New One‐Dimensional Ternary Niobium Sulfide Chloride, Nb₂₄S₉₅Cl₇

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Clinical Manifestations of Syphilitic Uveitis in the Korean Population

Cited by 6 publications

References 23 publications

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis

Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes

Synthesis and Crystal Structure of the New One‐Dimensional Ternary Niobium Sulfide Chloride, Nb24S95Cl7

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Product

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Synthesis and Crystal Structure of the New One‐Dimensional Ternary Niobium Sulfide Chloride, Nb₂₄S₉₅Cl₇