Clinical manifestations of toxicity in a series of 784 boric acid ingestions

Litovitz, T. A.; Klein‐Schwartz, Wendy; Oderda, Gary M.; Schmitz, Barbara F.

doi:10.1016/0735-6757(88)90001-0

Cited by 114 publications

(74 citation statements)

References 14 publications

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“…29 The pharmacological properties of BA, including ease of handling, low toxicity, an almost complete clearance via urine within 24 hours and the fact that it is not metabolized make it an attractive cancer treatment candidate. 28,[35][36][37][38][39] To date, five published studies have focused on the potential of BA to control progression of cancer at the cellular level. 17,18,20,21,40 Of these, only one study examined the ability of BA to inhibit prostate cancer cell migration.…”

Section: Discussionmentioning

confidence: 99%

Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability

Bradke

Hall

Carper

et al. 2008

Cell Adhesion & Migration

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We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues. Treatment at 24 hours with BA (≤500 μM) did not inhibit chemotaxis on fibronectin in any cell line. However, treatment over the same time course with concentrations of PBA as low as 1 μM significantly inhibited cancer cell migration without effecting nontumorigenic cell lines. The compounds did not affect cell adhesion or viability at 24 hours but did alter morphology; both decreased cancer cell viability at eight days. These results suggest that PBA is more potent than BA in targeting the metastatic and proliferative properties of cancer cells.

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Section: Discussionmentioning

confidence: 99%

Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability

Bradke

Hall

Carper

et al. 2008

Cell Adhesion & Migration

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“…A more recent article from 1988 reviewed 784 cases of acute boric acid ingestion in which toxicity was minimal or absent [16]. The quantity of borate reported to have been ingested ranged from 10 mg to 88.8 g in the 692 asymptomatic patients (mean 0.9 g) and 100 mg to 55.5 g in the remaining symptomatic patients (mean 3.2 g).…”

Section: Discussionmentioning

confidence: 99%

“…Estimates of potentially toxic and lethal doses vary widely. At the extremes, there is a case in which death resulted from a 3-g ingestion in a 2-week-old infant and a report of 88.8 g ingested by one woman that seemed to have little obvious effect [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

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Ingestion of a denture cleanser: Did it cause gastric perforation?

Ingram

Baldwin

2008

J. Med. Toxicol.

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INTRODUCTIONEfferdent is a product designed to cleanse dentures in a container when added to water. The outside of the package clearly states in large, highlighted, capitalized letters: "Do not put tablets or solution directly in mouth." Despite this warning and similar ones found on other denture cleansing products, there were 1,512 reported exposures to denture cleanser products by the Toxic Exposure Surveillance System in 2005. Of these, 77% were in adults over 19 years old. Only 38 (2.5%) were intentional, 97.5% were accidental, 82 (5.4%) were treated in a healthcare facility, 8 (0.5%) were found to cause "moderate" complications, and only one resulted in death, though no further information is reported about this case [1]. CASE REPORTA 27-year-old man presented to an Emergency Department (ED) complaining of severe abdominal pain, diarrhea, and blood-tinged vomitus. Ten days prior the patient had been offered a job interview that required pre-employment urine drug testing. Because he had been smoking marijuana regularly, he followed a friend's suggestion to attempt manipulation of the cannabinoid assay through ingestion of Efferdent tablets. Seven days prior to presentation he ingested one tablet in a glass of water, which quickly resulted in abdominal pain. The following day he ingested two more tablets in water, which resulted in abdominal pain that continued to increase until presentation. He did not comment on whether the tablets were fully dissolved.The patient had no significant past medical or surgical history, took no medications, and had no allergies to medications. His family history was non-contributory. He denied any prior gastrointestinal symptoms. His social history was positive for tobacco abuse and negative for alcohol use.The patient's vital signs were: oral temperature, 36.1°C, heart rate 62 bpm, respiratory rate 18/minute, blood pressure 150/78 mmHg, and O 2 saturation 98% on room air. On physical examination, he was a thin male in moderate distress secondary to ABSTRACTIntroduction: Human ingestion of denture cleansers leading to gastric perforation has not previously been described. Case Report: A 27-year-old male ingested three denture cleanser tablets in water over two days in an attempt to cause a falsenegative result on a workplace urine drug screen. Seven days later he presented to an emergency department with a perforated gastric ulcer.Discussion: A literature review of cases and the chemistry of the components of his ingestion was conducted to determine the possible relationship between these events. Ingestion of intact fragments of the tablets would be likely to result in significant gastric toxicity, but ingestion of dissolved tablets would be unlikely to have caused his illness.

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“…Previous studies indicated that over 90% of boric acid and borax administrated could be absorbed through the gastrointestinal and respiratory tracts of the experimental animals (Hunt 1989;Bai and Hunt 1996;Litovitz et al 1988). Although low levels of boron may be beneficial to the bone, excessive uptake of boron can cause symptoms such as coarse hair coats, scaly tails, swollen and desquamated pads of the paws, bloody eye discharge, body weight loss and shrunken scrotum (Weir and Fisher 1972;Heindel et al 1992;Price et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Investigations on boron levels in drinking water sources in China

Xing

Zhou

et al. 2009

Environ Monit Assess

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To evaluate boron contamination of public drinking water in China, both dissolved and total boron contents in 98 public drinking water sources from 49 cities, 42 brands of bottled water samples from supermarkets in several cities, and 58 water samples from boron industrial area were measured by inductively coupled plasma-mass spectrometry (ICP-MS). Our experimental results showed that boron existed in public drinking water sources mainly in dissolved status with total

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Clinical manifestations of toxicity in a series of 784 boric acid ingestions

Cited by 114 publications

References 14 publications

Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability

Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability

Ingestion of a denture cleanser: Did it cause gastric perforation?

Investigations on boron levels in drinking water sources in China

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