Clinical Manifestations Vary with Different Age Spectrums in Infants with Kawasaki Disease

Liu, Hao Chuan; Lo, Chiao; Hwang, Betau; Lee, Pi Chang

doi:10.1100/2012/210382

Cited by 28 publications

(30 citation statements)

References 35 publications

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“…In this study, 21 (20%) patients had cardiac abnormalities. The frequency of cardiac abnormalities are different in reports from Thailand (6.2%) ( 32 ), Taiwan (11%), ( 33 ) Hong Kong (15%) ( 22 ), USA (17%) ( 34 ), Oman (25%) ( 4 ), Finland (28%) ( 35 ), China (32%) ( 24 ), and Turkey (33%) ( 30 ). There was no significant difference between the cardiac and non-cardiac patients except for the duration of hospital course and interval between onset of disease and treatment.…”

Section: Discussionmentioning

confidence: 79%

Clinical and Epidemiological Characteristics of Kawasaki Disease

Shamsizadeh

Kajbaf

Razavi

et al. 2014

Jundishapur J Microbiol

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Background:Kawasaki disease (KD) is an acute multisystem vascular syndrome of unknown etiology that is the leading cause of acquired heart disease in children of developed counties.Objectives:We aimed to evaluate the epidemiological characteristics and clinical manifestations of KD in children residing in the southwest of Iran.Patients and Methods:In this retrospective study, we reviewed the medical records of all children with KD who had been admitted to the main children’s hospital of Ahvaz, southwest Iran, from March 2000 to March 2010. Data regarding clinical and epidemiological characteristics, management, and the outcome of disease for each patient were obtained. The patients were divided into cardiac and non-cardiac groups based on echocardiographic results.Results:In total, 104 patients with KD (66 boys and 38 girls) were enrolled in this study. The male to female ratio was 1.7:1. The mean ± SD age of the patients was 33.6 ± 24.2 months. Most (87.2%) cases were from urban areas. The disease occurred more frequently during winter and spring. Furthermore, 61.5% of the children had the criteria of classic KD, and 38.5% were labeled as incomplete KD. The mean ± SD of the duration of hospital stay was 6.9 ± 2.4 days. The mean time between illness and admission to the hospital was 6.47 ± 2.6 days. The most common sign was fever, followed by conjunctivitis and oral changes. In total, 20% of the patients had cardiac abnormalities. There was no significant statistical difference between the cardiac and non-cardiac groups according to age, sex, clinical manifestations, laboratory findings, and cessation of fever. The duration of hospital stay and the time between onset of illness and diagnosis were longer in the cardiac group. All patients received intravenous immunoglobulin and aspirin. Only one patient continued to have cardiac abnormalities after 6 months of follow-up.Conclusions:Kawasaki disease is not rare in southwest of Iran. The age, gender distribution and clinical findings are similar to that of other reports. Patients with cardiac abnormalities had delayed treatment and prolonged hospital stays.

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Section: Discussionmentioning

confidence: 79%

Clinical and Epidemiological Characteristics of Kawasaki Disease

Shamsizadeh

Kajbaf

Razavi

et al. 2014

Jundishapur J Microbiol

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“…approximately 90 % of the patients. Palmar or plantar erythema with subsequent desquamation is described in 40-50 % of the children [21]. Later, Beau lines (transverse depressions of the nails) can be found.…”

Section: At a Glance: Acute Hemorrhagic Edema Of Infancymentioning

confidence: 97%

“…Polymorphic exanthema as well as changes of the oral mucosa (swelling of the lips, fissures, erosions, hyperemia, strawberry tongue and bleeding) are found in approximately 90 % of the patients. Palmar or plantar erythema with subsequent desquamation is described in 40-50 % of the children [21]. Later, Beau lines (transverse depressions of the nails) can be found.…”

Section: At a Glance: Acute Hemorrhagic Edema Of Infancymentioning

confidence: 99%

Vasculitis in childhood – a dermatological approach

Benoit¹,

Goebeler²

2013

J Deutsche Derma Gesell

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Summary Vasculitis, an inflammatory condition affecting the blood vessels, may be restricted to a single organ or involve several organ systems. The size of the involved vessels is an important criterion for categorization of vasculitides, which is a prerequisite for rapid diagnosis and initiation of treatment. In pediatric patients, this particularly applies to Kawasaki disease. However, making the diagnosis can be challenging for dermatologists as skin involvement may be variable and non‐specific. In contrast, Henoch‐Schönlein purpura (IgA vasculitis) presents with the classic picture of palpable purpura. It predominantly affects postcapillary venules frequently following upper respiratory tract infections. Severe organ involvement is relatively rare in children and the prognosis is good. As renal involvement may occur during the course of disease, continuous monitoring is required. Acute hemorrhagic edema of infancy is considered as a distinct type of immune complex vasculitis and is characterized by a triad of fever, edema and rosette‐shaped purpura. The clinical course of this rare disease is usually benign and self‐limited. Due to the variability of clinical symptoms and manifestations, management of childhood vasculitides represents a special challenge requiring interdisciplinary collaboration. Dermatologists should be aware of their important role especially for making an early diagnosis.

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“…• Menor de 6 meses con fiebre inexplicable mayor o igual a 7 días (en el grupo de niños menores de 1 año se encuentra una mayor frecuencia de EK incompleto y de afectación coronaria) 6 .…”

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