Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea

Kim, Ho; Kim, Nayoung; Kang, Jung Mook; Park, Young Soo; Lee, Dong Hoon; Kim, Yu Rim; Kim, Sang Woo; Jung, Hyun Chae; Song, Sung Joon

doi:10.1097/meg.0b013e3283086757

Cited by 44 publications

(49 citation statements)

References 33 publications

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“…It is assumed and also found in several studies [15], that PG test results directly correlate with H. pylori status in patients, based on the fact that H. pylori is the main etiological factor for atrophic changes in the gastric mucosa [5,8,17,18].…”

Section: Introductionmentioning

confidence: 88%

“…27 No 1: [11][12][13][14][15][16][17] At present, the gold standard for diagnosis of gastric mucosal changes is the biopsy performed during an upper gastrointestinal endoscopy followed by histological examination [3,6]. Evaluation of the histological status of the mucosa can be performed using the updated Sydney System, the Operative Link on Gastritis Assessment (OLGA) and the Operative Link for Gastric Intestinal Metaplasia assessment (OLGIM) systems.…”

Section: Introductionmentioning

confidence: 99%

“…It has been estimated that PG I, secreted by oxyntic glands, mostly reflects the degree of potential atrophy. However, the ratio of PG I/ PG II is considered to be a more sensitive indicator of atrophic changes, especially if H. pylori infection is present, which stimulates the secretion of PG II due to inflammation and cellular proliferation [3,15,16].…”

Section: Introductionmentioning

confidence: 99%

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Pepsinogen Test for the Evaluation of Precancerous Changes in Gastric Mucosa: a Population-Based Study

Sjomina

Pavlova

Daugule

et al. 2018

JGLD

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Aims: The aim of the study was to evaluate the rationale of blood pepsinogen (PG) testing in population based screening settings.Methods: Participants from a cross-sectional population-based study of cardiovascular risk factors in Latvia were invited to participate in the current study. Pepsinogen I and II were measured in blood samples taken during the initial study and at follow-up; upper gastrointestinal endoscopy was performed. There were three groups of patients: with moderately decreased (PG I< 70 ng/ml and PG I/PG II ratio < 3), with strongly decreased (PG I< 30 ng/ml and PG I/PG II ratio < 2), and with normal PG level. Biopsy with H. pylori detection was performed (updated Sydney system).Results: Results from 259 patients were analyzed. Pepsinogens were decreased in 133 (51.4%), H. pylori was positive in 177 (66.0%) cases. Mean age was significantly lower in patients with normal compared to strongly decreased PG level group (52.8 vs. 64.1 years, p<0.001). Prevalence of severe corpus atrophy was higher in the strongly decreased compared to the normal PG test group: 7.0% vs. 0%; the same tendency was noted in the distribution of OLGA stages III-IV – 10.5% and 0.0%, OLGIM stages III-IV – 3.5% and 0%, and low-grade dysplasia – 15.8% and 2.4% (p<0.05). Two cases of gastric cancer were found; both presented decreased PG levels. A strong association between H. pylori eradication and PG ratio dynamics was found (p<0.05).Conclusions: All high-risk lesions were found in the decreased PG test groups; two cancer cases were revealed.However, PG demonstrated low specificity and low value of repeated testing. The value of PG as a sole test for gastric cancer risk is limited.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pepsinogen Test for the Evaluation of Precancerous Changes in Gastric Mucosa: a Population-Based Study

Sjomina

Pavlova

Daugule

et al. 2018

JGLD

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“…However, as PG II exhibits a greater rise relative to PG I, [43][44][45] the PG I/II ratio decreases in the presence of H. pylori-infection (Fig. 1).…”

Section: H Pylori Infection and The Effect Of H Pylori Eradication mentioning

confidence: 99%

“…43,49-52 Kim et al 43 showed that male gender was associated with higher PG I than female but there was no correlation in case of PG II or PG I/II ratio in 1,485 healthy subjects (964 [64.9%] H. pylori positive cases). However, PG I was not associated with body mass index (BMI).…”

Section: The Effect Of Other Factors On Pepsinogen Levelsmentioning

confidence: 99%

The Role of Serum Pepsinogen in Detection of Gastric Cancer

Ryu¹,

Park

Lee

et al. 2009

J Korean Gastric Cancer Assoc

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The incidence of gastric cancer is very high in Japan, Korea, and China. Reducing the morbidity and mortality associated with gastric cancer requires early diagnosis, which can be facilitated by applying gastroscopy more frequently in high-risk groups. A strategy of population screening for gastric cancer is currently being adopted in Korea, Japan, and the Matsu region of Taiwan, but using different screening methods. In addition, the history of pepsinogen (PG) in research as a gastric cancer biomarker has varied, in that the use of serum levels of PGI and PGII and the PGI/PGII ratio as gastric cancer screening tools was introduced in Japan before 1990, but in Korea the first research results were only reported in 2008. This review first evaluates the physiology of PG, followed by the usefulness or limitations of serum PG testing with regard to the detection of gastric cancer. Finally, the factors affecting the efficacy of PG tests as a gastric cancer biomarker (i.e., Helicobacter pylori infection status, gender, histopathologic features, and cancer location and depth) are evaluated. It was found that the strategies used to increase the efficacy of PG tests should be individualized in each country according to the seroprevalence of H. pylori. (Gut Liver 2010;4:307-319)

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The Normal Stomach: Anatomy, Specimen Dissection and Histology Relevant to Pathological Practice

Ban

2012

Morson and Dawson's Gastrointestinal Pathology

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Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea

Cited by 44 publications

References 33 publications

Pepsinogen Test for the Evaluation of Precancerous Changes in Gastric Mucosa: a Population-Based Study

Pepsinogen Test for the Evaluation of Precancerous Changes in Gastric Mucosa: a Population-Based Study

The Role of Serum Pepsinogen in Detection of Gastric Cancer

The Normal Stomach: Anatomy, Specimen Dissection and Histology Relevant to Pathological Practice

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