Clinical metabolomics by NMR revealed serum metabolic signatures for differentiating sarcoidosis from tuberculosis

Clinical metabolomics investigation of rheumatoid arthritis patients receiving ayurvedic whole system intervention

“…The present study aims to evaluate the intervention effect of Whole system ayurvedic treatment following serum metabolomics approach based on analysis of 1D 1 H NMR spectra recorded on the serum samples of RA patients before intervention (RA; n = 37), during the intervention (RAF; n = 26) and post intervention (RAT; n = 36) with reference to Healthy Control (HC; n = 27). Before starting the concentration profiling of serum metabolites using NMR suite of CHENOMX software, first the CPMG spectral peaks were assigned for specific serum metabolites, making composite use of the 800 MHz metabolite spectral database library of CHENOMX NMR suite and previously reported NMR chemical shifts of serum metabolites [ [20] , [21] , [22] , [23] ] ( Fig. 1 B).…”