“…Finally, the impact of early refills was assessed in 46 out of 116 studies (exclusion of initiation studies and implementation methods based on all days supplied as oversupply is automatically included). In general, for patients who refilled Time between end of one prescription and the start of a subsequent one Treatment gap of >X days between the end of one prescription and the start of the subsequent one [16,30,37,41,43,51,58,59,62,63,79,81,109,112,126,128,147,149,151,158,173,176] Treatment gap of >X days between the end of one prescription (prescription end corrected for early refills) and the start of the subsequent one [47,60,80] Treatment gap of >X days between the end of one prescription (prescription end corrected for inpatient stays) and the start of the subsequent one [38,91] Treatment gap of >X days between the end of one prescription (prescription end corrected for early refills and inpatient stays) and the start of the subsequent one [98,119] Treatment gap of >X days (value of X adapted for inpatient stays) between the end of one prescription and the start of the subsequent one [85] Treatment gap of >X days between the end of one prescription and the start of the subsequent one and no re-initiation during the subsequent period [154,155]…”