Clinical monosensitivity to salmonid fish linked to specific IgE-epitopes on salmon and trout beta-parvalbumins

Immunological cross-reactivity between four distant parvalbumins—Impact on allergen detection and diagnostics

“…The next most diverse antibody should be the Atlantic salmon isoforms, however, the anti-salmon antibodies were surprisingly the least cross-reactive only reacting to 52.5% of species parvalbumin (anti-basa parvalbumin 82.5% and anti-pilchard parvalbumin 80%). These findings are supported by clinical studies where fish allergic patients can be monosensitive to Salmonids (Kuehn et al, 2011;Peñas et al, 2014;Vázquez-Cortés et al, 2012), which could be attributed to salmon parvalbumin having a different IgE epitope at the N-terminal region of parvalbumin (Peñas et al, 2014;Perez-Gordo et al, 2011;. This phenomena may also be occurring for the rabbit antibodies analyzed in this study.…”

Fish Allergens at a Glance: Variable Allergenicity of Parvalbumins, the Major Fish Allergens

“…Generally, the high clinical cross-reactivity among fishes has been attributed to cross-reacting IgE antibodies recognizing parvalbumins from several species (68). Recently, clinical monosensitivity to salmonid fishes has been linked to salmonid parvalbumin-specific IgE antibodies suggesting that cross-reactivity among fish parvalbumins may be restricted to these closely related fishes (23, 25). …”

“…Several allergenic parvalbumins have been identified in commonly consumed fish, cod (beta-1, beta-2), salmon (beta-1, beta-2), and herring (beta-1, beta-2, beta-3) (5). During studies of monosensitivity to salmonid fishes, different antigenic regions were assumed but only a single epitope was defined as a species-specific allergy marker (23, 25). This unique epitope was localized on a single isoform, the beta-1 salmon parvalbumin.…”

Unusual sensitization to parvalbumins from certain fish species

“…In only 2 recent publications, monosensitivity to salmonid fishes was attributed to parvalbumins. 7,8 We now provide evidence that also restricted IgE reactivity to species of the Siluriformes order and to angler can be attributed to parvalbumins. The parvalbumins from pangasius, wels catfish, and angler have so far not been sequenced, but obviously they harbor specific IgE epitopes not present on parvalbumins from other bony fish.…”