Clinical, Morphological and Biochemical Studies on a Malignant Testicular Tumor123

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades

“…55,58,145 We are aware, however, of a case seen by Dr. Robert Scully in 1959 that developed in a 3.4-year-old boy who presented with a rapidly enlarging scrotal mass that replaced the left testis. 167 There was both clinical and biochemical evidence of excess glucocorticoid and androgen production, and this tumor subsequently metastasized to the retroperitoneum and caused the death of the patient secondary to tumor-related hypertension and a consequent cerebrovascular accident. Microscopically there was a predominance of sheet-like growth of pleomorphic polygonal cells with eosinophilic cytoplasm (Fig.…”

Malignant Adrenal Rest Tumor of the Retroperitoneum Producing Adrenocortical Steroids

“…Whether these criteria can be applied to adrenal rest tumors has never been assessed. In the present case, supraclavicular lymph node metastasis was found from the time of first admission confirming malignancy, and the histopathologic findings including the MIB1 index (about 10%) were consistent with a malignant diagnosis according to Weiss. To our knowledge, only 11 cases of malignant adrenal rest tumors (with the exception of the present case) have been so far reported [2][3][4][5][6][7][8][9][10][11][12]. In these cases, the primary sites of malignant adrenal rest tumor were the testis, liver, retroperitoneum, kidney, and spinal cord, and seven cases showed hormonal symptoms.…”

“…The adrenal rest rarely persists until adulthood as it generally undergoes atrophy and disappears within a few years after birth [2]; however, a neoplasm can arise from the adrenal rest. Their malignant counterpart, however, is extremely rare, and only a few sporadic cases have been reported [2][3][4][5][6][7][8][9][10][11][12].…”

Studies in a Patient with an Ectopic Adrenocortical Tumor

“…Microscopically, the tumor proved to be an adrenocortical carcinoma. No evidence could be found that it represented a metastasis from a primary lesion in the adrenals, and it seems reasonable to postulate that it had arisen from ectopic adrenal tissue (2)(3)(4)(5).…”

“…If an ectopic adrenocortical neoplasm is suspected, however, surgical treatment is mandatory, and localization of the tumor is very important: preoperative knowledge of the location of such a tumor could minimize both the duration and the extent of the exploration. Ectopic adrenocortical tissue has been found in diverse sites, ranging from the gonads to the upper retroperitoneal space (2)(3)(4)(5). This report describes a patient with Cushing's syndrome from whom two atropic adrenals had been removed at an earlier abdominal exploration.…”