Clinical–Neurobiological Correlations in Female Adolescents with Non-Suicidal Self-Injurious Behavior

Изнак, Е. В.; Изнак, А. Ф.; Олейчик, И. В.; Zozulya, S A

doi:10.1134/s0362119721050054

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…The level of proinflammatory cytokines and tumor necrosis factors in the peripheral blood of NSSI patients observed in the laboratory is higher and is positively correlated with frontal electroencephalography activity, suggesting that inflammation affects frontal lobe dysfunction, increases impulsive traits, and leads to NSSI recurrence ( Kim et al, 2020 ). In addition, some inflammatory factor changes, such as decreased interleukin-8 and increased white blood cell count (WBC), are also associated with suicide and NSSI ( Keaton et al, 2019 ; Iznak et al, 2021 ). This change in immune function promotes the occurrence and development of chronic inflammatory diseases including cancer and diabetes ( Timmons et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Tumor markers and depression scores are predictive of non-suicidal self-injury behaviors among adolescents with depressive disorder: A retrospective study

Qin

Chen

et al. 2022

Front. Neurosci.

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BackgroundNon-suicidal self-injury (NSSI) is an important risk factor for suicide in adolescents with depressive disorders; therefore, it is important to predict NSSI occurrence as early as possible. Disturbances in biological rhythms are characteristic manifestations of depressive disorders and can lead to immune dysfunction, leading to changes in tumor markers. This study aimed to produce an index that utilizes tumor markers to predict NSSI behaviors among adolescents with depressive disorders.MethodsA total of 120 hospitalized adolescent patients with depressive disorders aged 14–24 years were included in this study. Participants were divided into NSSI and non-NSSI groups based on self-reports using the Ottawa Self-Injury Inventory. Demographics, tumor marker concentrations, other peripheral blood indices, Hamilton Depression Rating Scale (HDRS) scores, and Hamilton Anxiety Rating Scale (HAMA) scores were compared between the two groups. Logistic regression analysis was conducted to develop a joint index, and a receiver operating characteristic (ROC) curve was created to predict NSSI behaviors among adolescents with depressive disorders.ResultsCompared with the non-NSSI group, the NSSI group had significantly higher insight, retardation, insomnia, hopelessness, psychiatric anxiety, total HDRS and HAMA scores, and significantly higher levels of cancer antigen 125 (CA-125), cancer antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA). In addition, a joint index was developed by combining CA-125, CA19-9, CEA, HDRS total score, HAMA total score and age using multiple logistic regression to predict NSSI behaviors. The area under the curve was 0.831, with a sensitivity and specificity of 0.734 and 0.891, respectively.ConclusionA combination of depression score, tumor marker levels, and age can identify NSSI behaviors among adolescents with depressive disorders.

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Section: Introductionmentioning

confidence: 99%

Tumor markers and depression scores are predictive of non-suicidal self-injury behaviors among adolescents with depressive disorder: A retrospective study

Qin

Chen

et al. 2022

Front. Neurosci.

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Clinical-neurophysiological correlations in female adolescents with heboid depression

Изнак

Iznak

Damyanovich

et al. 2022

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Interrelations of Clinical, Neurophysiological and Neuroimmunological Parameters in Depressive Patients after COVID-19

Изнак¹,

Iznak²,

Zozulya³

et al. 2023

Psychiatry

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The aim of the study was to assess the impact of the coronavirus infection on clinical, neurophysiological and neuroimmunological parameters, as well as on their interrelations in young female depressive patients. Patients: a comparative analysis of quantitative clinical (according to the HDRS-17 scale), neurophysiological (EEG) and neuroimmunological (according to the “Neuro-immuno-test” technology) parameters was carried out in two groups of female depressive patients aged 16–25 years. The ﬁrst group included 46 patients who recovered from a mild or asymptomatic coronavirus infection (“COVID” group). The second group included 40 patients who were studied and treated before the start of the pandemic (i.e., those who did not have COVID — the “pre-COVID” group) and corresponding to patients of the ﬁrst group by gender, age, diagnoses, and syndrome structure of disorders. In all patients, prior to the start of the course of therapy, a multichannel EEG was recorded with the measurement of absolute spectral power and neuroimmunological parameters in blood plasma were determined. Methods: clinicalpsychopathological, psychometric, neurophysiological, neuroimmunological, statistical. Results: signiﬁcantly greater scores of somatic disorders cluster of HDRS-17 scale, and increased amount of slow-wave EEG activity (of delta, theta1 and theta2 subbands) were revealed in the “COVID” group in comparison to patients of “pre-COVID” group. Mean values of neuroimmunological parameters were not differed statistically between two groups, but the values of neuroplasticity markers (levels of autoantibodies to the S100b protein and to the basic myelin protein) in the “pre-COVID” group correlated positively with the spectral power values of the main EEG rhythm (alpha2 and alpha3 sub-bands), and in “COVID” group — with the values of the spectral power of slow-wave EEG activity, reﬂecting a reduced brain functional state. Conclusion: the results obtained indicate that coronavirus infection, even in mild or asymptomatic forms, affects the clinical, neurophysiological and neuroimmunological parameters, as well as their interrelations in young female depressive patients.

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Clinical–Neurobiological Correlations in Female Adolescents with Non-Suicidal Self-Injurious Behavior

Cited by 3 publications

References 23 publications

Tumor markers and depression scores are predictive of non-suicidal self-injury behaviors among adolescents with depressive disorder: A retrospective study

Tumor markers and depression scores are predictive of non-suicidal self-injury behaviors among adolescents with depressive disorder: A retrospective study

Clinical-neurophysiological correlations in female adolescents with heboid depression

Interrelations of Clinical, Neurophysiological and Neuroimmunological Parameters in Depressive Patients after COVID-19

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