Clinical neurophysiology of Parkinson’s disease and parkinsonism

Chen, Robert; Berardelli, Alfredo; Bhattacharya, Amitabh; Bologna, Matteo; Chen, Kai‐Hsiang Stanley; Fasano, Alfonso; Helmich, Rick C.; Hutchison, William D.; Kamble, Nitish; Kühn, Andrea A.; Macerollo, Antonella; Neumann, Wolf‐Julian; Pal, Pramod Kumar; Paparella, Giulia; Suppa, Antonio; Udupa, Kaviraja

doi:10.1016/j.cnp.2022.06.002

Cited by 49 publications

(30 citation statements)

References 414 publications

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“…Additionally, clinical studies on PD are rapidly advancing, allowing for not only the observation of symptomatic or pathological implications but also possible treatments that help reduce these alterations [ 106 , 107 , 108 ]. As the diagnosis of this disease involves multiple factors, the use of other diagnostic tools that fit new technologies is a great candidate for correct interpretation and treatment, including the use of these tools, such as new specific biomarkers (pathological species of α-syn and digital and potential MRI biomarkers), specific treatments for chronic inflammation and the application of machine learning in imaging studies and genetic focuses [ 106 , 107 , 108 , 109 , 110 , 111 , 112 ].…”

Section: Discussionmentioning

confidence: 99%

Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Rangel

Marín-Márquez

Hernández-Contreras

et al. 2023

IJMS

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Parkinson’s disease is a neurodegenerative disease whose progression and clinical characteristics have a close bidirectional and multilevel relationship with the process of neuroinflammation. In this context, it is necessary to understand the mechanisms involved in this neuroinflammation–PD link. This systematic search was, hereby, conducted with a focus on the four levels where alterations associated with neuroinflammation in PD have been described (genetic, cellular, histopathological and clinical-behavioral) by consulting the PubMed, Google Scholar, Scielo and Redalyc search engines, including clinical studies, review articles, book chapters and case studies. Initially, 585,772 articles were included, and, after applying the inclusion and exclusion criteria, 84 articles were obtained that contained information about the multilevel association of neuroinflammation with alterations in gene, molecular, cellular, tissue and neuroanatomical expression as well as clinical-behavioral manifestations in PD.

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Section: Discussionmentioning

confidence: 99%

Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Rangel

Marín-Márquez

Hernández-Contreras

et al. 2023

IJMS

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“…Our previous studies using a single session of tbTUS led to a reduction in SICI in healthy individuals. 14,22 In PD patients, SICI is reduced and can be normalized by dopaminergic medications or subthalamic DBS, 2,24,28 whereas SICF is increased in PD. 29 We did not detect changes in SICI or SICF measured at single ISIs of 1.3 and 2 ms, respectively, following both active and sham a-tbTUS conditions.…”

Section: Discussionmentioning

confidence: 99%

“…

Parkinson's disease (PD) is a life-altering neurodegenerative disorder, with an estimated annual incidence rate ranging from 5 to over 35 new cases per 100,000 individuals worldwide. 1,2 Current treatments for PD involve dopaminergic pharmacotherapy, surgical intervention including deep brain stimulation (DBS), and non-pharmacologic supportive measures. 1 Although these treatments can alleviate motor symptoms such as bradykinesia, tremor, and rigidity, pharmacological therapies become less effective with disease progression and may cause adverse effects.

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confidence: 99%

Accelerated Transcranial Ultrasound Neuromodulation in Parkinson's Disease: A Pilot Study

Samuel,

Ding,

Sarica

et al. 2023

Movement Disorders

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ObjectiveLow‐intensity transcranial focused ultrasound (TUS) is a novel method for neuromodulation. We aimed to study the feasibility of stimulating the bilateral primary motor cortices (M1) with accelerated theta‐burst TUS (a‐tbTUS) on neurophysiologic and clinical outcomes in Parkinson's disease (PD).MethodsPatients were randomly assigned to receive active or sham a‐tbTUS for the first visit and the alternate condition on the second visit, at least 10 days apart. a‐tbTUS was administered in three consecutive sonications at 30‐minute intervals. We used an accelerated protocol to produce an additive effect of stimulation. Patients were studied in the OFF‐medication state. Transcranial magnetic stimulation (TMS)‐elicited motor‐evoked potentials (MEPs) were used to assess motor cortical excitability before and after TUS. Clinical outcomes after a‐tbTUS administration were assessed using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS)‐III.ResultsA total of 20 visits were conducted in 10 PD patients. Compared to the baseline, TMS‐elicited MEP amplitudes significantly increased following active but not sham sonication (P = 0.0057). MEP amplitudes were also higher following a‐tbTUS than sham sonication (P = 0.0064). There were no statistically significant changes in MDS‐UPDRS‐III scores with active or sham a‐tbTUS.Conclusionsa‐tbTUS increases motor cortex excitability and is a feasible non‐invasive neuromodulation strategy in PD. Future studies should determine optimal dosing parameters and the durability of neurophysiologic and clinical outcomes in PD patients. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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“…Parkinson’s disease (PD) is associated with many motor symptoms 1 , 2 ) . Patients with PD commonly experience gait disturbances such as small shuffling steps, an anteriorly shifted center of mass, decreased walking speed, poor balance, increased gait variability, and freezing of gait (FOG) as the disease progresses 3 ) .…”

Section: Introductionmentioning

confidence: 99%

The effects of visual cues from optical stimulation devices on gait disturbance in patients with Parkinson’s disease

et al. 2023

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[Purpose] The purpose of this study was to identify the optimal visual cues for gait disturbance in patients with Parkinson’s disease based on the luminous duration and the individual patient preferences for a wearable visual cue device. [Participants and Methods] Twenty-four patients with Parkinson’s disease walked while wearing only a visual cue device in the control condition. They then walked while the device was set to two stimulus conditions: the luminous duration at 10% and 50% of the individual gait cycle. After walking under the two stimulus conditions, the patients were asked for their preferred visual cue condition. The walking results were compared between the two stimulus conditions and the control condition. Gait parameters were compared among the three conditions. The comparisons with preference, non-preference, and control conditions were also made for the same gait parameter. [Results] When compared to the control condition, walking with visual cues in the stimulus conditions reduced stride duration and increased cadence. The preference and non-preference conditions had shorter stride durations than the control condition. Furthermore, the preference condition also resulted in a faster gait speed than the non-preference condition. [Conclusion] This study suggests that a wearable visual cue device with the patient’s preferred luminous duration may help manage gait disturbance in patients with Parkinson’s disease.

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Clinical neurophysiology of Parkinson’s disease and parkinsonism

Cited by 49 publications

References 414 publications

Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Accelerated Transcranial Ultrasound Neuromodulation in Parkinson's Disease: A Pilot Study

The effects of visual cues from optical stimulation devices on gait disturbance in patients with Parkinson’s disease

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