Clinical NMR imaging of the brain: 140 cases

Gm, Bydder; Steiner, R. E.; Young, IR; Hall, Alistair S.; Thomas, D. J.; Marshall, John; Pallis, C; Legg, N. J.

doi:10.1016/0730-725x(82)90211-9

Cited by 56 publications

(80 citation statements)

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“…The high level of graywhite matter contrast available with inversion-recovery (IR) sequences provides a basis for visualization of the normal process of myelination in infancy. Studies of adults have also shown that NMR imaging is sensitive to a variety of pathologic changes, including hemorrhage, infarction, edema, and neoplastic change, which are important in pediatric practice [1,[3][4][5][6][7][8][9][10][11][12][13]. Unlike computed tomography (CT), no hazard is associated with NMR imaging, and, unlike sonography, its applica tion in children is not limited by the closure of the fontanelles.…”

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confidence: 99%

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Clinical NMR imaging of the brain in children: normal and neurologic disease

Ma¹,

Jm²,

Gm³

et al. 1983

American Journal of Roentgenology

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In earlier reports, we commented on the potential of nuclear magnetic reso nance (NMR) for imaging of the brain in children [1, 2]. The high level of graywhite matter contrast available with inversion-recovery (IR) sequences provides a basis for visualization of the normal process of myelination in infancy. Studies of adults have also shown that NMR imaging is sensitive to a variety of pathologic changes, including hemorrhage, infarction, edema, and neoplastic change, which are important in pediatric practice [1,[3][4][5][6][7][8][9][10][11][12][13]. Unlike computed tomography (CT), no hazard is associated with NMR imaging, and, unlike sonography, its applica tion in children is not limited by the closure of the fontanelles. We have now completed NMR examinations of eight normal children and 52 patients up to 13 years of age with a variety of neurologic diseases. The normal appearances and results of these clinical studies are presented. Subjects and Methods Approval for this study was obtained from the Research Ethics

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confidence: 99%

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mentioning

confidence: 99%

Clinical NMR imaging of the brain in children: normal and neurologic disease

Ma¹,

Jm²,

Gm³

et al. 1983

American Journal of Roentgenology

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“…The age range was from 2 to 11 years with 19 between 5 and 10 years. The site of origin was fourth ventricle (13), lateral ventricle (4), third and lateral ventricle (4), and third ventricle (3). In one animal a gross tumor was not apparent.…”

Section: Domestic Animalsmentioning

confidence: 99%

Brain Tumors in Man and Animals: Report of a Workshop

1986

Environmental Health Perspectives

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This report summarizes the results of a workshop on brain tumors in man and animals. Animals, especially rodents are often used as surrogates for man to detect chemicals that have the potential to induce brain tumors in man. Therefore, the workshop was focused mainly on brain tumors in the F344 rat and B6C3F1 mouse because of the frequent use of these strains in long-term carcinogenesis studies. Over 100 brain tumors in F344 rats and more than 50 brain tumors in B6C3F1 mice were reviewed and compared to tumors found in man and domestic or companion animals. In the F344 rat, spontaneous brain tumors are uncommon, most are of glial origin, and the highly undifferentiated glioblastoma multiforme, a frequent tumor of man was not found. In the B6C3F1 mouse, brain tumors are exceedingly rare. Lipomas of the choroid plexus and meningiomas together account for more than 50% of the tumors found. Both rodent strains examined have low background rates and very little variability between control groups.

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“…This is illustrated by the major contribution a New Zealander, Graham Bydder, has made to the development of magnetic resonance imaging while working in the United Kingdom (54). Such a contribution would have been difficult to achieve in Australia or New Zealand.…”

Section: Modern Eramentioning

confidence: 99%