Clinical nutrition in surgical oncology: Young AIOM-AIRO-SICO multidisciplinary national survey on behalf of NutriOnc research group

Marano, Luigi; Marmorino, Federica; Desideri, Isacco; Carbone, L.; Rizzo, Alessandro; Salvestrini, Viola; Roviello, Franco; Cinieri, Saverio; Donato, Vittorio; Luca, Raffaele De

doi:10.3389/fnut.2023.1045022

Cited by 4 publications

(4 citation statements)

References 52 publications

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Section: Discussionmentioning

confidence: 99%

“…Our results call for the implementation, development, and increased use of specific tools that enable nutritional assessment to improve the management of nutritional support in clinical practice. [21] From the keyword emergent analysis, it was found that prostate cancer and lung cancer were located at the top 15. If nutritional therapy is well applied in the treatment of various types of cancer, it can change the disease and treatment process.…”

Section: Analysis Of Keyword Burstsmentioning

confidence: 99%

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The development of cancer nutrition research from 2013 to 2022: a bibliometric and visualized analysis study

Zhang,

et al. 2023

Precision Nutrition

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Background: The use of nutrition in cancer treatment has become increasingly widespread in recent decades, and the current stage of nutritional support and assessment has had a positive effect on reducing the side effects of cancer treatment. Based on the analysis of international literature on “tumor nutrition,” we identified the current status of research, research hotspots, and frontiers and provided a theoretical basis and reference for the development of related research in China. This study aimed to conduct a bibliometric analysis of the global literature published from 2013 to 2022 to assess the current research directions. Methods: The Web of Science core collection was searched from 2013 to 2022. The VOSviewer 1.6.19 and CiteSpace 6.2.2 were adopted to conduct the analysis. Results: Following the inclusion and exclusion criteria, a total of 28,245 documents were collected. The number of articles issued annually was fluctuatingly increasing. These articles were written by 124,412 authors from 20,162 affiliations in 166 countries or regions and were published in 3110 journals. The leading authors were Susan M. Gapstur, Heiner Boeing, and Hanping Shi. All publications were taken from 166 countries/regions and 20,162 organizations. The most productive countries were the United States and China. The most active institutions were the Harvard Medical School and University of Alberta. A total of 3110 journals contributed to this field, and the leading journals were Nutrients and Clinical Nutrition. The important author keywords occurred most frequently were cancer, nutrition, risk, survival, mortality, and sarcopenia. Conclusions: This study provided the dynamics and progress of nutrition research field. The studies about nutrition are booming. The current growth trend predicts that the global field of oncology nutrition will still increase. In addition to the traditional research on tumor nutrition, the development of interdisciplinary research should be promoted. Every country should strengthen international cooperation to enhance the influence of research results and solve many common scientific problems in the field of tumor nutrition research in multiple dimensions.

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Section: Discussionmentioning

confidence: 99%

Section: Analysis Of Keyword Burstsmentioning

confidence: 99%

The development of cancer nutrition research from 2013 to 2022: a bibliometric and visualized analysis study

Zhang,

et al. 2023

Precision Nutrition

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“…In 2020, young members of the Italian Association of Medical Oncology (AIOM), Italian Association of Radiotherapy and Clinical Oncology (AIRO), Italian Society of Surgical Oncology (SICO) and the Italian Society of Parenteral and Enteral Nutrition (SINPE) planned common research goals and founded the NutriOnc Research Group, aimed at implementing multidisciplinary strategies to improve patient quality of life 18 . The Scopus database was systematically searched between 1 January 1998 and 15 May 2023, in order to retrieve the worldwide literature concerning immunonutrition in relation to cancer, with the keywords ʻimmunonutritionʼ and ʻcancerʼ.…”

Section: Methodsmentioning

confidence: 99%

“…Accumulating evidence suggests that dietary factors, such as omega-3 fatty acids, arginine, nucleotides, and antioxidants, are thought to enhance immune cell function, modify the tumor microenvironment, reduce inflammation, and support tissue repair, thereby potentially improving cancer outcomes 15 – 17 . This realization has captivated the attention of the scientific community, leading to extensive investigations into the potential of immunonutrition as a complementary approach to conventional cancer therapies 12 , 18 – 20 . However, the evidence-based recommendations of these nutritional formulas in clinical practice are still scarce and limited to specific populations.…”

Section: Introductionmentioning

confidence: 99%

Mapping the landscape of immunonutrition and cancer research: A comprehensive bibliometric analysis on behalf of NutriOnc Research Group

De Felice,

Cattaneo,

Poto

et al. 2023

International Journal of Surgery

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The ongoing global health challenge of cancer is driving the pursuit of innovative avenues for prevention, treatment, and enhanced outcomes. The convergence of nutrition and immune modulation, known as immunonutrition, is ready to act as a catalyst for transformative change in cancer research and therapy. Our study employs a bibliometric analysis to uncover the evolving trends within immunonutrition and cancer research across the past 25 years. Bibliometric data, including authors, journals, affiliations, and countries, were analyzed using the Bibliometrix R package. Clustering algorithms were applied to keywords to identify thematic areas and their evolution. A total of 489 documents were analyzed, showing an annual growth rate of 8.7%, with a collaboration index of 5.41, highlighting comprehensive multidisciplinary involvement within this landscape. Core authors demonstrated sustained productivity, while occasional authors indicated widespread interest. The Medical University of Warsaw led in institutional contributions. Country-wise, Italy, France, and the USA emerged as forerunners in fostering research productivity. Key journals like “Clinical Nutrition” served as beacons, emphasizing the multidimensional nature of this topic. The analysis highlighted growing research output and several collaborations, indicating the importance of immunoenriched nutrition in cancer treatment. The interplay of core authors and diversified engagement harmoniously accentuates the cross-disciplinary nature of this burgeoning field. International collaboration facilitated knowledge exchange. Prominent documents shaped the field, emphasizing the significance of nutritional interventions. Thematic clusters revealed varied focuses, including pharmaconutrients, surgical approaches, inflammation, and specific cancers. The expanding research output suggests further development, particularly in exploring immunoenriched nutrition’s impact on cancer types and patient populations. The multidisciplinary nature and international collaborations enhance the field’s progress. Gaps in research underscore the need for original studies and personalized approaches. This study guides future research, informing evidence-based nutritional interventions and advancing cancer care practices.

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Machine learning-based screening and validation of liver metastasis-specific genes in colorectal cancer

Zheng,

He,

Zheng

et al. 2024

Sci Rep

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Colorectal liver metastasis (CRLM) is challenging in the clinical treatment of colorectal cancer. Limited research has been conducted on how CRLM develops. RNA sequencing data were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). Four machine learning algorithms were used to screen the hub CRLM-specific genes, including Least Absolute Shrinkage and Selection Operator (Lasso), Random forest, SVM-RFE, and XGboost. The model for identifying CRLM was developed using stepwise logistic regression and was validated using internal and independent datasets. The prognostic value of hub CRLM-specific genes was assessed using the Lasso-Cox method. The in vitro experiments were performed using SW620 cells. The CRLM identification model was developed based on four CRLM-specific genes (SPP1, ZG16, P2RY14, and PRKAR2B), and the model efficacy was validated using GSE41258 and three external cohorts. Five CRLM-specific prognostic hub genes, SPP1, ZG16, P2RY14, CYP2E1, and C5, were identified using the Lasso-Cox algorithm, and a risk score was constructed. The risk score was validated using the GSE39582 cohort. Three genes have both efficacy in identifying CRLM and prognostic value: ZG16, P2RY14, and SPP1. Immune infiltration and enrichment analyses demonstrated that SPP1 was associated with M2 macrophage polarization and extracellular matrix remodeling. In vitro experiments indicated that SPP1 may act as a cancer-promoting factor. The hub CRLM-specific gene SPP1 can help determine the diagnosis, prognosis, and immune infiltration of patients with CRLM.

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Clinical nutrition in surgical oncology: Young AIOM-AIRO-SICO multidisciplinary national survey on behalf of NutriOnc research group

Cited by 4 publications

References 52 publications

The development of cancer nutrition research from 2013 to 2022: a bibliometric and visualized analysis study

The development of cancer nutrition research from 2013 to 2022: a bibliometric and visualized analysis study

Mapping the landscape of immunonutrition and cancer research: A comprehensive bibliometric analysis on behalf of NutriOnc Research Group

Machine learning-based screening and validation of liver metastasis-specific genes in colorectal cancer

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