Clinical Observation of Minocycline Hydrochloride Ointment in the Treatment of Initial Peri-implant Inflammation

Abstract

To observe and analyze the therapeutic efficacy of minocycline hydrochloride ointment in the treatment of initial peri-implant inflammation, a total of 180 patients with initial peri-implant inflammation and treated at the Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital were enrolled. The patients were divided into the control group and the research group, with 90 patients in each group. Of those, patients in the research group were applied with minocycline hydrochloride ointment, while 10 % of iodine was placed around the teeth in patients of the control group. The therapeutic outcome was observed and compared between these groups. Comparison of the plaque index of both groups after treatment indicated that the outcome of the research group was better than that of the control group (P<0.05). The probing depth and sulcus bleeding index of the research group was significantly superior than that of the control group (P<0.05). Application of minocycline hydrochloride ointment in the treatment of initial peri-implant inflammation could significantly improve the therapeutic outcome.

Smart intraoral systems for advanced drug delivery

“…In comparison to the solid formulation, the administrative approaches of semi‐solid preparations are more flexible, assisted by a finger or a syringe to retain onto oral mucosal surfaces 47 . A commercial example is minocycline hydrochloride ointment, which has been employed for a variety of bacterial‐induced periodontitis and restorations after oral surgery 48 . Furthermore, liquid formulations exhibit the superior advantages of high dispersion, fast absorption, and low irritation over others, usually exerting local and systemic effects in the oral cavity 49,50 .…”

“…47 A commercial example is minocycline hydrochloride ointment, which has been employed for a variety of bacterial-induced periodontitis and restorations after oral surgery. 48 Furthermore, liquid formulations exhibit the superior advantages of high dispersion, fast absorption, and low irritation over others, usually exerting local and systemic effects in the oral cavity. 49,50 For instance, zolpidem tartrate has proven to be highly effective for the short-term treatment of insomnia with difficulty falling asleep.…”

Minocycline hydrochloride ointment combined with Vitapex paste is effective for middle-aged and elderly patients with combined periodontal-endodontic lesions

“…Minocycline hydrochloride ointment (MHO) has been extensively adopted in patients with CPELs over the past few years. It is a type of periodontal sustained-release local drug, with the main component of minocycline hydrochloride, which has the advantages of broad antibacterial spectrum and few drug-resistant bacteria [5]. It can alleviate various symptoms such as periodontitis and pulpitis caused by Porphyromonas gingivalis, Prevotella intermedia, Prevotella melaninogenicus, Ekeng corrosive bacteria, Fusobacterium nucleatum and Actinobacillus [6,7].…”