Clinical observation on therapeutic effect of filiform fire needle for vitiligo: A retrospective study

Huang, Mengya; Tang, Liangdan; Li, Xin; Cai, Hongjie; Li, Li; Wan, Shengkai; Long, Siyu; Zhou, Xun; Cao, Wenfu

doi:10.1111/dth.14415

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…Existing therapeutic approaches are ineffective and have adverse side effects, necessitating the development of new treatments. Even after multiple threadlike fire needle treatments, the vitiligo patches repigment significantly [ 17 ]. Systemic calcineurin antagonists were used for treating vitiligo, possibly alone or in conjunction with phototherapy, but their long-term efficacy is debatable [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Evaluation and Meta-Analysis of Randomized Controlled Trials of Fire Needle Combined Phototherapy for the Treatment of Vitiligo

Jiang

Long

Chen

et al. 2022

BioMed Research International

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This study investigated the fire needle and phototherapy combination for treating vitiligo through a meta-analysis of the published literature. Indeed, vitiligo is a common chronic skin condition characterized by the appearance of white patches. It is the most prevalent disorder, affecting approximately 1% of the global population. There is no known cure or clinical recommendation for treating vitiligo. The majority of medical guidelines suggest vitiligo treatment with the use of fire needles. Here, vitiligo was treated with a novel mechanism combining a fire needle with phototherapy. The handheld phototherapy devices include a fire needle option for disease treatment. Miniature lesions that could be used to detect and treat vitiligo at an early stage could be managed by hybrid-capable devices. The real-time study included more than 3,435 patients. The dosages were altered to control the adverse effects. Following treatment, granulation tissues developed on the injured skin, diminishing the shallow area and wound surface. The case studies demonstrate that combining phototherapy and fire needle therapy is more practical than the other methods.

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Section: Introductionmentioning

confidence: 99%

Systematic Evaluation and Meta-Analysis of Randomized Controlled Trials of Fire Needle Combined Phototherapy for the Treatment of Vitiligo

Jiang

Long

Chen

et al. 2022

BioMed Research International

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“…After checking and reading the titles and abstracts, 478 studies were initially screened. After reading the full text, studies that did not meet the inclusion criteria were excluded, and 11 articles remained for inclusion in the meta-analysis, [29][30][31][32][33][34][35][36][37][38][39] all of which were published in Chinese. The literature screening process is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Blade needle therapy versus conventional acupuncture for knee osteoarthritis: A meta-analysis

Yin¹,

Liu²,

Liu³

et al. 2022

Medicine

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Background: This study investigated the hypothesis that the efficacy of blade needle therapy for the treatment of knee osteoarthritis (KOA) is superior to that of conventional acupuncture. In addition, the efficacy of blade needle therapy versus conventional acupuncture for the treatment of KOA was analyzed in a meta-analysis.Methods: Randomized controlled trials (RCTs) of blade needle therapy and conventional acupuncture for treating KOA were retrieved from the electronic databases CNKL, Wanfang, VIP, PubMed, EMBASE and the Cochrane Library from the commencement of each database to July of 2021. Data were extracted and evaluated by 2 reviewers independently. RevMan 5.3 software was used to conduct the meta-analysis after the studies were evaluated.Results: A total of 11 RCTs were included, all from China, involving 1142 patients. The meta-analysis results showed that the effective rate of the blade needle group was better than that of the conventional acupuncture group (OR = 3.61, 95% CI [2.56-5.10], P < .00001). Conclusion:The efficacy of blade needle treatment for KOA is superior to that of conventional acupuncture, but more highquality studies are needed for future validation due to the low proportion of high-quality studies included and the possible bias factor.

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“…Although the treatment requires weekly hospital visits, increasing patient attendance, its integration with conventional treatments including topical medications and phototherapy signifcantly boosts outcomes and shortens therapy duration. Systematic reviews and meta-analyses have shown that treatment including fre needles had a signifcantly therapeutic efect in a shorter time than traditional methods without fre needles [30,31]. Moreover, the costefectiveness of FNT coupled with its synergistic benefts when used alongside other treatments, elevates its clinical utility [32].…”

Section: Discussionmentioning

confidence: 99%

Regulating the Wnt/β-catenin Signaling Pathway Promotes Repigmentation in Vitiligo Using Fire Needle Therapy

Xu,

Sun,

Zhang

et al. 2024

Dermatologic Therapy

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Background. Vitiligo is a dermatological disorder characterized by the depletion of melanocytes. The key to its treatment lies in the promotion of melanin regeneration. The Wnt/β-catenin signalling pathway assumes a pivotal role in this regenerative process. Fire needle therapy (FNT), a traditional Chinese medical technique, has emerged as a promising intervention. Methods. We analyzed gene expression associated with the Wnt/β-catenin signalling pathway in both normal skin and the lesions of patients with vitiligo in the Gene Expression Omnibus database (GEO database). Furthermore, we evaluated the gene expression of this pathway and assessed the effects of FNT on pigmentation and its influence on the Wnt/β-catenin signalling pathway in a vitiligo mouse model. Results. Compared to that of the normal skin, the mRNA levels of WNT10A, WNT10B, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5B, WNT7B, and LEF1 displayed significant decreases in the lesions of patients with vitiligo. Moreover, vitiligo mouse skin lesions improved following FNT, and the number of melanocytes and melanin levels increased. In addition, posttreatment, genes associated with the Wnt/β-catenin signalling pathway were revealed to be upregulated. Conclusion. FNT may play an important role in promoting pigmentation in vitiligo through modulation of the Wnt/β-catenin signalling pathway. This adds to the growing body of literature supporting the use of FNT to treat vitiligo. This, in turn, may inform clinical practice and improve patient outcomes.

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Clinical observation on therapeutic effect of filiform fire needle for vitiligo: A retrospective study

Cited by 7 publications

References 6 publications

Systematic Evaluation and Meta-Analysis of Randomized Controlled Trials of Fire Needle Combined Phototherapy for the Treatment of Vitiligo

Systematic Evaluation and Meta-Analysis of Randomized Controlled Trials of Fire Needle Combined Phototherapy for the Treatment of Vitiligo

Blade needle therapy versus conventional acupuncture for knee osteoarthritis: A meta-analysis

Regulating the Wnt/β-catenin Signaling Pathway Promotes Repigmentation in Vitiligo Using Fire Needle Therapy

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