“…The earliest records were of topical applications of lotions, vessicants, heat, the use of opiates, counter-irritants such as plasters and blistering, of the use of leeches, bleeding and purging. 14 Other more recent medications have included Stillbamadine, 15 Vitamin B, 16,17 vasodilator drugs, 18,19,20 intravenous histamine, 21 Chlorpromazine 22,23 and Mephensin Carbamate. Numerous other drugs have been tried, including quinine sulfate, 11 ferrous carbonate, hemlock, camphorated mercurial ointment, .ether and arsenic in gruel.…”