Clinical Observations on Use of Warfarin (Coumadin) Sodium, a New Anticoagulant

Malabsorption-associated warfarin resistance

“…and oral administration. 24 A dose of 5 mg warfarin i.v. was chosen as the starting dose, assuming that our patient would have an appropriate response to a normal starting dose if the medication reached his systemic circulation.…”

Novel oral anticoagulants: What dermatologists need to know

“…1,2 Warfarin blocks the activation of vitamin K, thereby preventing the formation of a necessary cofactor for the synthesis of calcium-dependent clotting factors, which include factors II, VII, IX, and X. Despite the efficacy of warfarin for numerous indications, its use in the clinical setting has been complicated by a narrow therapeutic index, abundant drug and dietary interactions, 3,4 and genetic polymorphisms that impact warfarin and vitamin K metabolism.…”