CLINICAL OBSERVATIONS WITH 1,6‐BIS(β‐CHLOROETHYLAMINO)‐1,6‐DEOXY‐D‐MANNITOL DIHYDROCHLORIDE (BCM) IN MALIGNANT DISEASES

Mannomustine in Treatment of Leukaemias, Polycythaemia, and Malignant Disorders

“…; " degranol "), a substance synthesized by Vargha as one of a series of compounds linking the actively cytotoxic chemical group 8-chlorethylamine with a naturally occurring substance, mannitol; it was thought that this would pass more readily through the cell membrane and therefore have a greater selectivity (Vargha et al, 1957 Mannomustine is a white crystalline compound readily soluble in water, and, although it remains stable for at least 24 hours, it should preferably be freshly prepared immediately before injection. There are a few reports of the therapeutic trial of this substance by Sellei et al (1956) and by Sellei and Eckhardt (1958) at the National Oncological Institute, Budapest.…”

Effect of Cyclophosphamide on Pain in Advanced Carcinoma of the Cervix

“…T o obtain this relief it was usually necessary to administer toxic doses which resulted in a marked reduction in the white cell and thrombocyte counts. (BATEMAN 1958, SELLEI & ECKHARDT 1958, SHIDER et COll. 1960 Twenty-three patients with pain from advanced carcinoma of the cervix were treated by systemic administration of cyclophosphamide.…”

Nitrogen Mustard in Palliation of Malignant Effusions

“…Treatment with Au-198 has certain inherent disadvantages, including the difficulty of handling it, but perhaps the most important of these is the radiation hazard involved to the medical and nursing personnel administering the treatment. More recently attempts have been made to treat malignant effusions with chemotherapeutic agents, thus avoiding the radiation risk, using nitrogen mustard (HN2), thiotepa (Bateman, 1955), and mannomustine dihydrochloride (" degranol ") (Sellei and Eckhardt, 1958). The series of cases described here were treated to assess the value of intracavity HN2 in the control of recurrent malignant effusions.…”