Clinical outcome after biliary drainage for metastatic colorectal cancer: Survival analysis and prognostic factors

Sellier, Floriane; Bories, Erwan; Sibertin-Blanc, Camille; Griffiths, Karolina; Dahan, Laétitia; Giovannini, Marc; Gaudart, Jean; Jf, Seitz; Laugier, R.; Caillol, Fabrice; Grandval, Philippe

doi:10.1016/j.dld.2017.09.121

Cited by 13 publications

(39 citation statements)

References 25 publications

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“…However, it is not sufficient to differentiate the likelihood of survival in stage IV cases. Therefore, new methods of predicting and improving outcome are being explored [ 7 – 10 ]. Numerous oncologists and clinical researchers have assessed the relevance of liver function tests (LFTs) for early detection of liver metastasis in patients with different types of cancer [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Abnormal Liver Function Induced by Space-Occupying Lesions Is Associated with Unfavorable Oncologic Outcome in Patients with Colorectal Cancer Liver Metastases

Jiang

Zhao

et al. 2018

BioMed Research International

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An early prediction of prognosis for patients with colorectal liver metastasis (CRLM) may help us determine treatment strategies. Liver function reflects the effect of the overall metastatic burden. We investigated the prognostic value of liver function in CRLM patients. In our study, patients with abnormal LFTs (liver function tests) had a poorer prognosis than did those with normal LFTs (P < 0.05). A multivariate analysis revealed that LFTs was an independent prognostic factor for CRLM. For those patients with abnormal LFTs, novel prognostic contour maps were generated using LFTs, and no positive correlation exists between the values of survival duration and abnormal LFTs. Additionally, the MTVR (metastatic tumor volume ratio) was measured directly by magnetic resonance imaging and was shown to be highly correlated to LFTs by a Pearson correlation analysis. A multivariate logistic regression analysis also demonstrated that the MTVR and hepatectomy were independently predictive of abnormal LFTs. The space-occupying effect of metastatic lesions can cause abnormal LFTs, resulting in a poor prognosis. Biochemical analyses of LFTs at the initial diagnosis of CRLM enable the stratification of patients into low- and high-risk groups; it may help clinicians determine promising treatment strategies.

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Section: Introductionmentioning

confidence: 99%

Abnormal Liver Function Induced by Space-Occupying Lesions Is Associated with Unfavorable Oncologic Outcome in Patients with Colorectal Cancer Liver Metastases

Jiang

Zhao

et al. 2018

BioMed Research International

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“…1, Appendix 3). [1,2,[12][13][14][15][16] All studies were cohort studies without comparison group and patients were identified retrospectively. Five studies were single-center and two were multicenter studies.…”

Section: Resultsmentioning

confidence: 99%

“…[12,13,16] In two studies either ERCP or PTC was initially used. [1,2] EUS was performed in two patients described in one study in whom initial ERCP failed. [2] Patient and disease characteristics are provided in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Malignant biliary obstruction is an ominous complication of metastatic colorectal cancer (mCRC) and is associated with a poor prognosis. [1][2][3] It has been reported to occur in 10% of patients with known mCRC. [1] Malignant biliary obstruction can be caused by either intrahepatic metastases or extrahepatic lymph node or peritoneal metastases located at the liver hilum or along the extrahepatic bile duct.…”

Section: Introductionmentioning

confidence: 99%

“…Median survival after the onset of jaundice is only around one month when treated with supportive care. [1][2][3] Improved palliative systemic therapy regimens, along with increased use of hepatic resections, showed improved overall survival in mCRC patients. Some agents however, in particular irinotecan, are contraindicated in patients with obstructive jaundice and hyperbilirubinemia.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical outcomes of biliary drainage of malignant biliary obstruction due to colorectal cancer metastases: A systematic review

Kastelijn

Loos²,

Welsing³

et al. 2021

European Journal of Internal Medicine

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Background and aims: Malignant biliary obstruction is an ominous complication of metastatic colorectal cancer (mCRC). Biliary drainage is frequently performed to relieve symptoms of jaundice or enable palliative systemic therapy, but effective drainage can be difficult to accomplish. The aim of this study is to summarize literature on clinical outcomes of biliary drainage in mCRC patients with malignant biliary obstruction. Methods: We searched Medline and EMBASE for studies that included patients with malignant biliary obstruction secondary to mCRC, treated with endoscopic and/or percutaneous biliary drainage. We summarized available data on technical success, clinical success, adverse events, systemic therapy administration and survival after biliary drainage. Results: After screening 3584 references and assessing 509 full-text articles, seven cohort studies were included. In these studies, rates of technical success, clinical success and adverse events varied between 63%-94%, 42%-81%, and 19%-39%, respectively. Subsequent chemotherapy was administered in 17%-56% of patients. Overall survival varied between 40 and 122 days across studies (278-365 days in patients who received subsequent chemotherapy, 42-61 days in patients who did not). Conclusions: Successful biliary drainage in mCRC patients can be challenging to achieve and is frequently associated with adverse events. Overall survival after biliary drainage is limited, but is significantly longer in patients treated with subsequent systemic therapy. Expected benefits of biliary drainage should be carefully weighed against its risks.

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Interventional Radiology in General Practice of Colorectal Cancer

Belet

Çapar

Sarıoğlu

2020

Colon Polyps and Colorectal Cancer

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Clinical outcome after biliary drainage for metastatic colorectal cancer: Survival analysis and prognostic factors

Cited by 13 publications

References 25 publications

Abnormal Liver Function Induced by Space-Occupying Lesions Is Associated with Unfavorable Oncologic Outcome in Patients with Colorectal Cancer Liver Metastases

Abnormal Liver Function Induced by Space-Occupying Lesions Is Associated with Unfavorable Oncologic Outcome in Patients with Colorectal Cancer Liver Metastases

Clinical outcomes of biliary drainage of malignant biliary obstruction due to colorectal cancer metastases: A systematic review

Interventional Radiology in General Practice of Colorectal Cancer

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