Clinical outcome after Hypofractionated Stereotactic Radiotherapy (HSRT) for benign skull base tumors

Mahadevan, Anand; Floyd, Scott R.; Wong, Eric T.; Chen, Clark; Kasper, Ekkehard M.

doi:10.3109/10929088.2011.565160

Cited by 31 publications

(20 citation statements)

References 63 publications

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“…However, reports of multi- session SRS are emerging. 18,34,72,76,89,150 These studies appear to demonstrate comparable local control to single fraction treatment, with perhaps fewer side effects and a lower incidence of symptomatic edema, particularly for non-basal/parasagittal or large meningiomas. In one of these reports, Unger reported on 173 patients and found that symptomatic edema was significantly less common following multifraction (typically 25 Gy in 5 fractions) SRS than single session (median 15 Gy) SRS.…”

Section: Resultsmentioning

confidence: 79%

Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review

Rogers

Barani

Chamberlain

et al. 2015

JNS

568

400

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Evolving interest in meningioma, the most common primary brain tumor, has refined contemporary management of these tumors. Problematic, however, is the paucity of prospective clinical trials that provide an evidence-based algorithm for managing meningioma. The current review summarizes the published literature regarding the treatment of newly diagnosed and recurrent meningioma, with an emphasis on outcomes stratified by World Health Organization (WHO) tumor grade. In particular this review focuses on patient outcomes following treatment (either adjuvant or at recurrence) with surgery or radiation therapy inclusive of radiosurgery and fractionated irradiation. Phase II trials for patients with meningioma have recently completed accrual within the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) consortia, and phase III studies are being developed. However, at present, there are no completed prospective, randomized trials assessing the role of either surgery or radiotherapy. Successful completion of future studies will require a multidisciplinary effort, dissemination of the current knowledge base, improved implementation of WHO grading criteria, standardization of response criteria and other outcome endpoints, and concerted efforts to address weaknesses in present treatment paradigms, particularly for patients with progressive or recurrent low grade meningioma, or with high-grade meningioma. In parallel efforts, Response Assessment in Neuro-Oncology (RANO) subcommittees are developing a manuscript on systemic therapies for meningioma, and a separate article proposing standardized endpoint and response criteria for meningioma.

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Section: Resultsmentioning

confidence: 79%

Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review

Rogers

Barani

Chamberlain

et al. 2015

JNS

568

400

View full text Add to dashboard Cite

show abstract

“…Many other larger studies have also confirmed the safety of single-fraction RS, (5,(7)(8)(9)(10) although far fewer and smaller studies have reported on hypofractionated RS. (11)(12)(13)(14) Our patient who had peritumoral oedema requiring VP shunt insertion had a larger tumour (7.17 cm 3 , median 1.68 cm 3 ) prior to RS, and this could have been a predisposing factor for complications. Chan et al's study (9) on FSRT found that tumour size was strongly predictive of neurosurgical complications, and that three-and five-year actuarial rates of freedom from any neurosurgical intervention were 100% and 97% for patients with tumour volume < 8 cm 3 , but were 74% and 47% for tumour volume > 8 cm 3 .…”

Section: Discussionmentioning

confidence: 97%

Local experience with radiosurgery for vestibular schwannomas and recommendations for management

Wong¹,

Low²,

Tan³

2018

smedj

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“…Orta dereceli hipofraksiyonun uzun dönem toksisiteden koruduğu bilinmektedir. [48,49] Stereotaktik beden radyoterapisi 3-5 fraksiyon kullanılmaktadır. [20] Olgularımızda doz sınırlayıcı yapılar nedeniyle 3-5 fraksiyon kullandığımız SBRT etkili ve takrarlanabilir bir yaklaşımdır.…”

Section: Discussionunclassified

Is stereotactic body radiotherapy a treatment option for pelvic recurrences?

Dağoğlu¹

2015

TJ Oncol

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KliNiK ÇalIŞma ORIGINAL ARTICLE oBJeCtIVeSWhen surgery is not adequate, stereotactic body radiotherapy (SBRT) has been used for recurrent cancers. We report the outcomes of case series with pelvic recurrences from colorectal cancer irradiated with SBRT. metHoDSRobotic Stereotactic Radiotherapy system was used. The dose fractionation scheme was individualized based on tumor volume and location and prior radiation dose. reSultSBetween February 2010 and December 2014, four patients were treated. Treatment regions were pelvic side wall for two patients and presacral for two patients. SBRT doses were 24 Gy in 3 fractions for three patients and 36.25 Gy in 5 fractions for one patient.One patient treated for pelvic side wall recurrence developed symptomatic noropathy at fist year. CoNCluSIoNLocal recurrence in pelvis after modern combined modality treatment for colorectal cancer is rare. However it presents a therapeutic dilemma when it occurs; often symptomatic and eventually life threatening. SBRT can be a useful modality in this setting.

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Clinical outcome after Hypofractionated Stereotactic Radiotherapy (HSRT) for benign skull base tumors

Cited by 31 publications

References 63 publications

Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review

Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review

Local experience with radiosurgery for vestibular schwannomas and recommendations for management

Is stereotactic body radiotherapy a treatment option for pelvic recurrences?

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