Clinical outcome in patients with high-grade internal carotid artery stenosis after irradiation

Marcel, M.; Leys, D.; Mounier‐Véhier, F.; Bertheloot, D.; Lartigau, É.; Pruvo, Jean‐Pierre; Al-Koussa, M.; Chevalier, D.; Hénon, Hilde

doi:10.1212/01.wnl.0000176033.64896.c6

Cited by 15 publications

(9 citation statements)

References 9 publications

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“…Only three of the 20 cancer deaths resulted from the initial cancer, and a new cancer developed in the rest. This is consistent with the experience of Marcel, et al, 13 who found in a series of 41 patients that the only predictor of death was the occurrence of a new malignancy. One might question whether some patients had cancer in evolution at the time of CAS.…”

Section: Discussionsupporting

confidence: 92%

Endovascular treatment for carotid artery stenosis after neck irradiation

Favre

Nourissat

Duprey

et al. 2008

Journal of Vascular Surgery

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Section: Discussionsupporting

confidence: 92%

Endovascular treatment for carotid artery stenosis after neck irradiation

Favre

Nourissat

Duprey

et al. 2008

Journal of Vascular Surgery

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“…The risk may vary with the severity of internal carotid artherosclerosis. The frequency of internal carotid stenosis following neck RT ranged from 12 to 60% (Cheng et al , 1999), although controversies remain (Marcel et al , 2005). The stroke risk associated with RT to the neck appears variable.…”

Section: Discussionmentioning

confidence: 99%

Increase in stroke risk in patients with head and neck cancer: a retrospective cohort study

et al. 2011

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Background:This study investigated the stroke risk in patients with head and neck cancers (HNCs) using population-based data.Methods:From claims collected in the Taiwan National Health Insurance database, we identified 13 390 HNC patients with diagnosis made in 2000–2002. A reference cohort of 53 517 non-cancer individuals matched for age, gender, and stroke risk factors was used for assessing stroke risk in follow-up to 2008.Results:The overall stroke incidence was 1.44-fold higher in the HNC than in the reference cohort (11.4 vs 7.9 per 1000 person-years). Adjusted hazard ratios (HRs) were 1.54 (95% confidence interval (CI): 1.40–1.68) for ischaemic stroke and 1.36 (95% CI: 1.09–1.69) for haemorrhagic stroke. The cancer-to-reference stroke incidence rate ratio was age dependent and the highest in the age group younger than 40 years (5.45, 95% CI: 3.78–7.87) and decreased with aging. Comparing different therapeutic modalities, HNC patients receiving both radiotherapy (RT) and chemotherapy (CT) had the highest stroke risk (HR: 1.46, 95% CI: 1.22–1.74), followed in sequence by those who had CT alone, RT alone, and without therapy.Conclusion:Patients with HNC are at increased risk of developing stroke, especially in the young age group and in those who received both RT and CT.

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“…Vasculopathy of medium-and large-sized vessels is the most common complication. The frequency of internal carotid stenosis following external radiation of the neck ranged from 12% to 60% (85), although there is some controversy (86). Routine ultrasound surveillance of carotid arteries following neck radiation has been suggested to prevent stroke (87).…”

Section: Therapy-relatedmentioning

confidence: 99%