Clinical outcome of a single procedure cryoballoon ablation for the treatment of atrial fibrillation: A real-world multicenter experience in Portugal

Cunha, Pedro Silva; Fonseca, Paulo; Laranjo, Sérgio; Sá, Fernando Montenegro; Valente, Bruno; Portugal, Guilherme; Gonçalves, Helena; Silva, Manuel Nogueira da; Brandão, Luis Felipe; Oliveira, Mário; Primo, João

doi:10.1016/j.repc.2022.02.012

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2023

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“…The medical team discussed with the patient the state of the illness and the possible benefits and risks of various treatments. Pulmonary vein isolation was addressed in the face of the results of the EAST-AFNET 4 trial ( 1 ) that indicate a rhythm-control strategy is superior to usual care (rate control in the majority of cases) in improving CV outcomes at five years and also the results of the author's centre that reported that a single ablation procedure in patients with persistent AF, resulted in 62.2% freedom from AF at a 22-month follow-up ( 2 ). Therefore, the option for catheter ablation treatment was chosen.…”

Section: Case Reportmentioning

confidence: 99%

Case report: Mutation in NPPA gene as a cause of fibrotic atrial myopathy

Cunha

Antunes

Laranjo

et al. 2023

Front. Cardiovasc. Med.

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Early-onset atrial fibrillation (AF) can be the manifestation of a genetic atrial myopathy. However, specific genetic identification of a mutation causing atrial fibrosis is rare. We report a case of a young patient with an asymptomatic AF, diagnosed during a routine examination. The cardiac MRI revealed extensive atrial fibrosis and the electrophysiology study showed extensive areas of low voltage. The genetic investigation identified a homozygous pathogenic variant in the NPPA gene in the index case and the presence of the variant in heterozygosity in both parents.

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Section: Case Reportmentioning

confidence: 99%